| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ralimetinib dimesylate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.116543 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0915584 |
| PRELID2 | PRELI domain containing 2 | 0.0817081 |
| FNDC3B | fibronectin type III domain containing 3B | 0.062467 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0509816 |
| DST | dystonin | 0.0509574 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0490636 |
| MACROD2 | MACRO domain containing 2 | 0.0474603 |
| SMYD3 | SET and MYND domain containing 3 | 0.0433939 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0389946 |
| RAD51B | RAD51 paralog B | 0.0375084 |
| WWOX | WW domain containing oxidoreductase | 0.0356891 |
| NBAS | neuroblastoma amplified sequence | 0.0316389 |
| FHIT | fragile histidine triad | 0.0304068 |
| NAV2 | neuron navigator 2 | 0.030014 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0286896 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0284606 |
| CDH13 | cadherin 13 | 0.0275351 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0273735 |
| GPR137B | G protein-coupled receptor 137B | 0.0272733 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0271336 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 0.0269107 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.026812 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0265605 |
| YEATS2 | YEATS domain containing 2 | 0.026089 |
| FMN1 | formin 1 | 0.0258706 |
| RNF24 | ring finger protein 24 | 0.0250753 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0250025 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.024358 |
| VGLL4 | vestigial-like family member 4 | 0.0241023 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0239856 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0236707 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0235436 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0230476 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0226355 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0225855 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0222705 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0221452 |
| ASPH | aspartate beta-hydroxylase | 0.0221019 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0220624 |
| CNKSR3 | CNKSR family member 3 | 0.021937 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0216976 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0214489 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.021393 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0211103 |
| MAP4 | microtubule-associated protein 4 | 0.0210347 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0209496 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.020839 |
| CLEC2D | C-type lectin domain family 2, member D | 0.0199041 |
| DPP6 | dipeptidyl-peptidase 6 | 0.0198993 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0198923 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0191621 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0189991 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0189315 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0188774 |
| MTAP | methylthioadenosine phosphorylase | 0.0188701 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0188478 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0185362 |
| XPO1 | exportin 1 | 0.0184354 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0183996 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0183781 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0182474 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0182265 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0181942 |
| FOXP1 | forkhead box P1 | 0.0180921 |
| ANGPTL4 | angiopoietin-like 4 | 0.0180533 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0177452 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.0175562 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 0.0173939 |
| MELTF | melanotransferrin | 0.0173104 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.017258 |
| FLNA | filamin A, alpha | 0.0171906 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0170521 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0170356 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0170295 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0168845 |
| ITGB5 | integrin, beta 5 | 0.0167447 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.016721 |
| VCL | vinculin | 0.0165545 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0164923 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0163867 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0163439 |
| TRIM9 | tripartite motif containing 9 | 0.0163224 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0162558 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0162379 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.016222 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0162035 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0160565 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0160412 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0160029 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0159755 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0159022 |
| TENM3 | teneurin transmembrane protein 3 | 0.0157988 |
| CEP250 | centrosomal protein 250kDa | 0.0157737 |
| TUSC3 | tumor suppressor candidate 3 | 0.0155122 |
| BBX | bobby sox homolog (Drosophila) | 0.0155102 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0154248 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0151805 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0150435 |
| PRKCE | protein kinase C, epsilon | 0.014915 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.421767 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.324814 |
| VIM | vimentin | -0.2056 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.100406 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0822116 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0778569 |
| FTL | ferritin, light polypeptide | -0.0775505 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0758178 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0672152 |
| PGK1 | phosphoglycerate kinase 1 | -0.0612288 |
| NDRG1 | N-myc downstream regulated 1 | -0.0571784 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0569796 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0538124 |
| ACTG1 | actin gamma 1 | -0.0533856 |
| UBC | ubiquitin C | -0.0524202 |
| POTEF | POTE ankyrin domain family, member F | -0.052336 |
| PKM | pyruvate kinase, muscle | -0.0485282 |
| PMEL | premelanosome protein | -0.0476611 |
| LSAMP | limbic system-associated membrane protein | -0.0472017 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0460517 |
| RAB7A | RAB7A, member RAS oncogene family | -0.044208 |
| SQSTM1 | sequestosome 1 | -0.0431938 |
| MT2A | metallothionein 2A | -0.0409064 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0400965 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0383282 |
| IER3 | immediate early response 3 | -0.0366632 |
| CANX | calnexin | -0.036535 |
| RHOA | ras homolog family member A | -0.0363464 |
| RPL35A | ribosomal protein L35a | -0.035872 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0351404 |
| LDHA | lactate dehydrogenase A | -0.034337 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0341038 |
| TMSB10 | thymosin beta 10 | -0.0339706 |
| HMGA1 | high mobility group AT-hook 1 | -0.0339355 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0336907 |
| FBXO11 | F-box protein 11 | -0.0336405 |
| TPI1 | triosephosphate isomerase 1 | -0.0332044 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0328081 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.032725 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0325513 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0323743 |
| MT1X | metallothionein 1X | -0.0321298 |
| SPAG9 | sperm associated antigen 9 | -0.0316569 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0312028 |
| RPS6 | ribosomal protein S6 | -0.0304418 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0301361 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0300209 |
| EMP1 | epithelial membrane protein 1 | -0.0297826 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0296498 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0293098 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0290721 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0279811 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0278617 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0277874 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0262025 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0261631 |
| SEC24A | SEC24 family member A | -0.0254333 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0251919 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0246492 |
| EGR1 | early growth response 1 | -0.024484 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0243586 |
| CADM1 | cell adhesion molecule 1 | -0.0243436 |
| RPL8 | ribosomal protein L8 | -0.0243104 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0242634 |
| HDLBP | high density lipoprotein binding protein | -0.0241119 |
| WASF2 | WAS protein family, member 2 | -0.0240956 |
| CD63 | CD63 molecule | -0.0233697 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0232856 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.023244 |
| MORF4L2 | mortality factor 4 like 2 | -0.0229977 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0229192 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0228907 |
| APOD | apolipoprotein D | -0.0228351 |
| FRMD4A | FERM domain containing 4A | -0.0228345 |
| RPL19 | ribosomal protein L19 | -0.0228308 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.022761 |
| ARF1 | ADP-ribosylation factor 1 | -0.0223085 |
| CTSD | cathepsin D | -0.0218941 |
| RACK1 | receptor for activated C kinase 1 | -0.0217782 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0217339 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.021645 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0215949 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.021436 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0213636 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0213149 |
| RPS4X | ribosomal protein S4, X-linked | -0.0213095 |
| HDAC8 | histone deacetylase 8 | -0.0211284 |
| RPL32 | ribosomal protein L32 | -0.0209286 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.020927 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0207827 |
| SHISA5 | shisa family member 5 | -0.0206901 |
| WDR45B | WD repeat domain 45B | -0.0206611 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0206038 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0203847 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | -0.0201981 |
| COPA | coatomer protein complex, subunit alpha | -0.0201559 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0201504 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0200038 |
| S100A10 | S100 calcium binding protein A10 | -0.0199677 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0199664 |
