| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.11824 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0848133 |
| RPS12 | ribosomal protein S12 | 0.082237 |
| MT2A | metallothionein 2A | 0.0812083 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0804101 |
| NAV2 | neuron navigator 2 | 0.0802754 |
| RPS3 | ribosomal protein S3 | 0.0510949 |
| ZNF292 | zinc finger protein 292 | 0.0494579 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0439986 |
| FLNA | filamin A, alpha | 0.0428341 |
| PRELID2 | PRELI domain containing 2 | 0.0405393 |
| RPL37A | ribosomal protein L37a | 0.0391526 |
| ASPH | aspartate beta-hydroxylase | 0.0383271 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0379702 |
| PCBP2 | poly(rC) binding protein 2 | 0.0379559 |
| RUNX1 | runt-related transcription factor 1 | 0.0353104 |
| OGA | O-GlcNAcase | 0.0346713 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0343759 |
| CDH13 | cadherin 13 | 0.0341777 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0329054 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0327347 |
| CADM1 | cell adhesion molecule 1 | 0.0317993 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0315487 |
| RPL9 | ribosomal protein L9 | 0.031408 |
| MYOF | myoferlin | 0.0304927 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0300557 |
| FMNL2 | formin-like 2 | 0.0297404 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0296279 |
| CDK19 | cyclin-dependent kinase 19 | 0.0293354 |
| B2M | beta-2-microglobulin | 0.0289785 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0286371 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0271352 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0268948 |
| ENO1 | enolase 1, (alpha) | 0.0268051 |
| RAI1 | retinoic acid induced 1 | 0.0266737 |
| SYNJ2 | synaptojanin 2 | 0.0261767 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0259091 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0254349 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0250455 |
| TPM3 | tropomyosin 3 | 0.0249857 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0246632 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0245888 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0242923 |
| RPL7 | ribosomal protein L7 | 0.024157 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0238445 |
| RPS17 | ribosomal protein S17 | 0.0238414 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.023539 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.023468 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0234012 |
| CEP250 | centrosomal protein 250kDa | 0.0233968 |
| DSTN | destrin (actin depolymerizing factor) | 0.0233946 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0233191 |
| YEATS2 | YEATS domain containing 2 | 0.0228882 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0226166 |
| FLNB | filamin B, beta | 0.0224617 |
| JMJD1C | jumonji domain containing 1C | 0.0224425 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0224179 |
| HELZ | helicase with zinc finger | 0.022408 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0222817 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0219472 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0217589 |
| DTNA | dystrobrevin, alpha | 0.0215751 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0212896 |
| RPS8 | ribosomal protein S8 | 0.020658 |
| RPS6 | ribosomal protein S6 | 0.0204865 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0201183 |
| RPL7A | ribosomal protein L7a | 0.01997 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0195737 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0194821 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0194624 |
| RPL13A | ribosomal protein L13a | 0.0192515 |
| MATR3 | matrin 3 | 0.019211 |
| PTEN | phosphatase and tensin homolog | 0.0191933 |
| TMEM14B | transmembrane protein 14B | 0.0191799 |
| FAM13A | family with sequence similarity 13, member A | 0.0191217 |
| RPLP2 | ribosomal protein, large, P2 | 0.0190989 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0189527 |
| SET | SET nuclear proto-oncogene | 0.0187731 |
| APP | amyloid beta (A4) precursor protein | 0.0185883 |
| SDC4 | syndecan 4 | 0.0180526 |
| RPL23 | ribosomal protein L23 | 0.0179787 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0175731 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.017573 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0175697 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0173528 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0172199 |
| RPL26 | ribosomal protein L26 | 0.0170975 |
| EFNA5 | ephrin-A5 | 0.0170343 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0169639 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0168063 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0167998 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0167978 |
| GOLGA4 | golgin A4 | 0.0167847 |
| RPL12 | ribosomal protein L12 | 0.0166514 |
| RPL5 | ribosomal protein L5 | 0.0166 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0165979 |
| ANXA1 | annexin A1 | 0.0165848 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0165665 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0165168 |
| ANKRD36 | ankyrin repeat domain 36 | 0.01646 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.227138 |
| FN1 | fibronectin 1 | -0.15638 |
| GLIS3 | GLIS family zinc finger 3 | -0.152058 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.146434 |
| VCL | vinculin | -0.144613 |
| BICC1 | BicC family RNA binding protein 1 | -0.133631 |
| IER3 | immediate early response 3 | -0.123462 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111535 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0849437 |
| KYNU | kynureninase | -0.0837544 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0831571 |
| VCAN | versican | -0.0781205 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0731422 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0715863 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0702586 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0621181 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.061229 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0609357 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.060149 |
| FRMD4A | FERM domain containing 4A | -0.0581152 |
| RAI14 | retinoic acid induced 14 | -0.0574756 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0568042 |
| HMGA2 | high mobility group AT-hook 2 | -0.0565812 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0563113 |
| NABP1 | nucleic acid binding protein 1 | -0.0549487 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0523839 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0521961 |
| UBC | ubiquitin C | -0.0509844 |
| PALLD | palladin, cytoskeletal associated protein | -0.0505727 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0495946 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0487156 |
| SMAD3 | SMAD family member 3 | -0.0481234 |
| THBS1 | thrombospondin 1 | -0.0476316 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0464854 |
| CANX | calnexin | -0.0463325 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0461817 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0449023 |
| NAV1 | neuron navigator 1 | -0.044643 |
| RIGI | RNA sensor RIG-I | -0.044056 |
| PDE10A | phosphodiesterase 10A | -0.0432157 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0430423 |
| EGR1 | early growth response 1 | -0.0427548 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0417322 |
| HLA-B | major histocompatibility complex, class I, B | -0.0417239 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0413928 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0410385 |
| VMP1 | vacuole membrane protein 1 | -0.0403299 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0395868 |
| DIAPH2 | diaphanous-related formin 2 | -0.0395398 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.039002 |
| AHNAK | AHNAK nucleoprotein | -0.0385773 |
| TUBB | tubulin, beta class I | -0.0376948 |
| INHBA | inhibin, beta A | -0.0376284 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0374671 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0372047 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0363213 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0360303 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0355789 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0340145 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0339178 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0335393 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0330505 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0325423 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0322255 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0320854 |
| QKI | QKI, KH domain containing, RNA binding | -0.032026 |
| RRBP1 | ribosome binding protein 1 | -0.0315593 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0311188 |
| OSMR | oncostatin M receptor | -0.0306445 |
| MAP1B | microtubule-associated protein 1B | -0.0302675 |
| PGK1 | phosphoglycerate kinase 1 | -0.0300807 |
| RND3 | Rho family GTPase 3 | -0.0299924 |
| COL1A1 | collagen, type I, alpha 1 | -0.0297406 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.029071 |
| RNF213 | ring finger protein 213 | -0.0281169 |
| CTSB | cathepsin B | -0.0278277 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0277232 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | -0.0269523 |
| TOP1 | topoisomerase (DNA) I | -0.02694 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0269214 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0266002 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0265905 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0265844 |
| FBXO11 | F-box protein 11 | -0.0265795 |
| CTSD | cathepsin D | -0.0264647 |
| INTS6 | integrator complex subunit 6 | -0.0263364 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0259375 |
| IL6 | interleukin 6 | -0.0259265 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0258507 |
| HLA-E | major histocompatibility complex, class I, E | -0.0256076 |
| LOX | lysyl oxidase | -0.0255421 |
| CLIC4 | chloride intracellular channel 4 | -0.0255202 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0252933 |
| ACTG1 | actin gamma 1 | -0.0251221 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0249154 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0248017 |
| SMAD2 | SMAD family member 2 | -0.0247743 |
| GNAS | GNAS complex locus | -0.0247474 |
| FAM20C | family with sequence similarity 20, member C | -0.0245113 |
| GOLGB1 | golgin B1 | -0.0242795 |
