Ralimetinib dimesylate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMYD3 SET and MYND domain containing 3 0.0813043
NAP1L1 nucleosome assembly protein 1-like 1 0.0640787
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0593791
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0550554
ZNF292 zinc finger protein 292 0.0528612
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0474041
RPS12 ribosomal protein S12 0.0451624
RPL23 ribosomal protein L23 0.0434867
ANLN anillin, actin binding protein 0.0427506
SFXN1 sideroflexin 1 0.0398464
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0397367
MKI67 marker of proliferation Ki-67 0.0394686
ANKRD28 ankyrin repeat domain 28 0.0393932
SMC4 structural maintenance of chromosomes 4 0.0387628
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0383082
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0380783
SKIC3 SKI3 subunit of superkiller complex 0.0376825
NBAS neuroblastoma amplified sequence 0.0373609
TXNRD1 thioredoxin reductase 1 0.037266
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0366009
ANKRD11 ankyrin repeat domain 11 0.0353685
GOLGA4 golgin A4 0.0352959
WDPCP WD repeat containing planar cell polarity effector 0.0344241
XPO1 exportin 1 0.0343352
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0339937
FAM13A family with sequence similarity 13, member A 0.033764
KIAA1328 KIAA1328 0.0329285
RPL12 ribosomal protein L12 0.0327578
CEP250 centrosomal protein 250kDa 0.032588
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0324735
MATR3 matrin 3 0.0322942
PNISR PNN-interacting serine/arginine-rich protein 0.0318086
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0315062
COG5 component of oligomeric golgi complex 5 0.0311955
SEPTIN2 septin 2 0.0310306
RNF145 ring finger protein 145 0.0309081
DIAPH3 diaphanous-related formin 3 0.0307841
TMEM245 transmembrane protein 245 0.0306834
RPL9 ribosomal protein L9 0.0305641
SET SET nuclear proto-oncogene 0.0305462
CKAP5 cytoskeleton associated protein 5 0.0302728
TBC1D5 TBC1 domain family, member 5 0.0302606
PUM2 pumilio RNA-binding family member 2 0.0302124
RPL31 ribosomal protein L31 0.0300583
AVL9 AVL9 homolog (S. cerevisiase) 0.0299672
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297186
RACK1 receptor for activated C kinase 1 0.0296205
SGO2 shugoshin 2 0.0292966
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0291136
KPNB1 karyopherin (importin) beta 1 0.0291018
ECT2 epithelial cell transforming 2 0.0289336
RPL26 ribosomal protein L26 0.0288796
RBM26 RNA binding motif protein 26 0.0278615
CDC27 cell division cycle 27 0.0277174
NUP58 nucleoporin 58 0.0276569
RPL37A ribosomal protein L37a 0.0275507
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0275201
PSME4 proteasome (prosome, macropain) activator subunit 4 0.027357
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0267429
SNX14 sorting nexin 14 0.0265543
ZNF148 zinc finger protein 148 0.0263641
RPLP1 ribosomal protein, large, P1 0.0262124
NCKAP1 NCK-associated protein 1 0.0256819
HMGB2 high mobility group box 2 0.0256086
RPS3 ribosomal protein S3 0.0254308
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0250401
NCAPD2 non-SMC condensin I complex, subunit D2 0.024997
TPR translocated promoter region, nuclear basket protein 0.0249231
MYH9 myosin, heavy chain 9, non-muscle 0.0247783
VIM vimentin 0.0246314
RPS17 ribosomal protein S17 0.0245887
TM9SF2 transmembrane 9 superfamily member 2 0.0244546
ZMYND8 zinc finger, MYND-type containing 8 0.0243768
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242984
UBAC2 UBA domain containing 2 0.02427
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0241365
B2M beta-2-microglobulin 0.0241049
PCBP2 poly(rC) binding protein 2 0.02405
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0240322
TCERG1 transcription elongation regulator 1 0.0239703
TMF1 TATA element modulatory factor 1 0.023952
ELP2 elongator acetyltransferase complex subunit 2 0.0237595
TTLL10 tubulin tyrosine ligase-like family member 10 0.023696
TENT2 terminal nucleotidyltransferase 2 0.0236693
TPX2 TPX2, microtubule-associated 0.0236174
CENPF centromere protein F, 350/400kDa 0.0235536
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0232479
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0232092
RPS6 ribosomal protein S6 0.02253
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0224735
ARL15 ADP-ribosylation factor-like 15 0.0221609
FANCI Fanconi anemia, complementation group I 0.0221341
TNRC6A trinucleotide repeat containing 6A 0.0221139
PDE4D phosphodiesterase 4D, cAMP-specific 0.0221125
SRSF11 serine/arginine-rich splicing factor 11 0.0220081
MT2A metallothionein 2A 0.0219332
RAD21 RAD21 homolog (S. pombe) 0.0219101
KIF4A kinesin family member 4A 0.0218361
TNPO1 transportin 1 0.0217974
FBXL17 F-box and leucine-rich repeat protein 17 0.0217313

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.393745
FNDC3B fibronectin type III domain containing 3B -0.133011
HMGA2 high mobility group AT-hook 2 -0.126065
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.116932
ZSWIM6 zinc finger, SWIM-type containing 6 -0.113013
INTS6 integrator complex subunit 6 -0.0947592
PRKCA protein kinase C, alpha -0.0889496
FMNL2 formin-like 2 -0.0809404
RIGI RNA sensor RIG-I -0.0800657
PRSS23 protease, serine, 23 -0.077574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0774062
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0767796
IGFBP3 insulin-like growth factor binding protein 3 -0.0733346
MACF1 microtubule-actin crosslinking factor 1 -0.0720651
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0720112
DST dystonin -0.0713144
LDHA lactate dehydrogenase A -0.0662434
ZBTB20 zinc finger and BTB domain containing 20 -0.0650073
SLC38A2 solute carrier family 38, member 2 -0.0648987
LOC112694756 uncharaterized LOC112694756 -0.0578679
RAD51B RAD51 paralog B -0.0577732
FLNB filamin B, beta -0.0573927
VCL vinculin -0.0555302
POTEF POTE ankyrin domain family, member F -0.0548445
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0546472
ATG7 autophagy related 7 -0.0544979
RAI14 retinoic acid induced 14 -0.0528158
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.052664
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0516346
EGR1 early growth response 1 -0.0513461
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0511269
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0496349
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0487015
NAV2 neuron navigator 2 -0.0479485
THSD4 thrombospondin, type I, domain containing 4 -0.0477974
NT5E 5'-nucleotidase, ecto (CD73) -0.047731
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0453515
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0452599
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0444513
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.04434
AHNAK AHNAK nucleoprotein -0.0441594
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0440414
TM4SF1 transmembrane 4 L six family member 1 -0.0440136
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0430473
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0424077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0415499
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0413561
SH3KBP1 SH3-domain kinase binding protein 1 -0.0407225
WNK1 WNK lysine deficient protein kinase 1 -0.0406443
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0406162
ATXN1 ataxin 1 -0.0405873
PCNX4 pecanex 4 -0.0402245
PTPRK protein tyrosine phosphatase, receptor type, K -0.0399841
MAP1B microtubule-associated protein 1B -0.0395895
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0392673
NDRG1 N-myc downstream regulated 1 -0.0387828
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0387631
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0387258
SQSTM1 sequestosome 1 -0.0379147
IER3 immediate early response 3 -0.0378122
PTK2 protein tyrosine kinase 2 -0.0376443
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0375646
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0372616
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0372151
SVIL supervillin -0.0370284
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0359724
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0359651
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0358681
TRIO trio Rho guanine nucleotide exchange factor -0.0356119
SOD2 superoxide dismutase 2, mitochondrial -0.0354999
NABP1 nucleic acid binding protein 1 -0.0354526
HOOK2 hook microtubule-tethering protein 2 -0.0354047
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0352714
BTG1 B-cell translocation gene 1, anti-proliferative -0.0351147
HDAC9 histone deacetylase 9 -0.0349199
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0347896
PRR16 proline rich 16 -0.0343215
SDC4 syndecan 4 -0.0342594
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0342242
FTH1 ferritin, heavy polypeptide 1 -0.0341667
ATM ATM serine/threonine kinase -0.034146
NAV3 neuron navigator 3 -0.0337174
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0334421
EGFR epidermal growth factor receptor -0.0331688
TMSB10 thymosin beta 10 -0.0331295
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0331164
BIRC6 baculoviral IAP repeat containing 6 -0.0329729
LMO7 LIM domain 7 -0.032541
ASXL1 additional sex combs like transcriptional regulator 1 -0.0324544
OSMR oncostatin M receptor -0.0324529
FMN1 formin 1 -0.0324054
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0322769
PCED1B PC-esterase domain containing 1B -0.0322712
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0314323
SKIL SKI-like proto-oncogene -0.0312247
ACTG1 actin gamma 1 -0.0306474
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0304714
CYTH1 cytohesin 1 -0.0300347
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0298255
RASAL2 RAS protein activator like 2 -0.0297718