Ralimetinib dimesylate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.0852781
LAMB3 laminin, beta 3 0.0712344
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0711459
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0681705
RPS3 ribosomal protein S3 0.0605845
SRRM2 serine/arginine repetitive matrix 2 0.0602882
KMT2C lysine (K)-specific methyltransferase 2C 0.0549317
RPS12 ribosomal protein S12 0.0539086
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0516518
ATXN1 ataxin 1 0.0506419
RNF43 ring finger protein 43 0.0484038
PRRC2C proline-rich coiled-coil 2C 0.0483962
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0472129
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0471678
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0457352
GARS1 glycyl-tRNA synthetase 1 0.0454426
DSCAM Down syndrome cell adhesion molecule 0.0444892
COG5 component of oligomeric golgi complex 5 0.0441553
PCNX1 pecanex 1 0.0437105
AREG amphiregulin 0.0423845
MTDH metadherin 0.0422683
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0415306
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.041384
KDM6A lysine (K)-specific demethylase 6A 0.0405063
NCKAP1 NCK-associated protein 1 0.0402261
KDM4B lysine (K)-specific demethylase 4B 0.0400398
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0393251
RPL26 ribosomal protein L26 0.0392685
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0392647
SEPTIN9 septin 9 0.0390149
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0387374
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0384451
NEBL nebulette 0.0384189
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0382479
RPL18 ribosomal protein L18 0.0376486
KTN1 kinectin 1 (kinesin receptor) 0.0374133
FLNA filamin A, alpha 0.0368333
TSC22D2 TSC22 domain family, member 2 0.036606
RPL37A ribosomal protein L37a 0.0356751
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0356361
TES testin LIM domain protein 0.0353105
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0348194
STRN3 striatin, calmodulin binding protein 3 0.0346187
ANKRD11 ankyrin repeat domain 11 0.0344184
SFPQ splicing factor proline/glutamine-rich 0.0339466
ANKRD12 ankyrin repeat domain 12 0.0337862
FLOT1 flotillin 1 0.0337625
NUP58 nucleoporin 58 0.0335583
GOLGA4 golgin A4 0.0334642
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0333912
CAMTA1 calmodulin binding transcription activator 1 0.0333319
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0331565
PUM2 pumilio RNA-binding family member 2 0.0328478
SFXN1 sideroflexin 1 0.0327787
SNX13 sorting nexin 13 0.0325912
EVA1C eva-1 homolog C (C. elegans) 0.0325484
SLTM SAFB-like, transcription modulator 0.0324333
NBAS neuroblastoma amplified sequence 0.0324145
KLC1 kinesin light chain 1 0.0322421
YAP1 Yes-associated protein 1 0.0319032
WDFY3 WD repeat and FYVE domain containing 3 0.0317128
OGA O-GlcNAcase 0.0316044
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0314905
EREG epiregulin 0.0314749
PDE4B phosphodiesterase 4B, cAMP-specific 0.0312981
MAP2K3 mitogen-activated protein kinase kinase 3 0.0310568
ZFAND3 zinc finger, AN1-type domain 3 0.030855
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0307994
ALCAM activated leukocyte cell adhesion molecule 0.0307555
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0306362
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0306004
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0305272
PRELID2 PRELI domain containing 2 0.0303517
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0303222
FHL2 four and a half LIM domains 2 0.0303065
TMF1 TATA element modulatory factor 1 0.0302489
SRSF11 serine/arginine-rich splicing factor 11 0.0301118
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0301078
FOXJ3 forkhead box J3 0.0299768
UBQLN1 ubiquilin 1 0.0299741
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0297447
KDM3A lysine (K)-specific demethylase 3A 0.0296426
SEPTIN2 septin 2 0.0295874
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0294314
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0292949
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0292578
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0290304
SLMAP sarcolemma associated protein 0.0288625
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0287152
DDB2 damage-specific DNA binding protein 2, 48kDa 0.028546
ADGRA3 adhesion G protein-coupled receptor A3 0.0285272
ANO6 anoctamin 6 0.0284378
NCEH1 neutral cholesterol ester hydrolase 1 0.0284228
FNBP1L formin binding protein 1-like 0.0281888
MYO6 myosin VI 0.0279851
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.027854
PFKP phosphofructokinase, platelet 0.0277564
JMJD1C jumonji domain containing 1C 0.0275386
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0275287
EIF5 eukaryotic translation initiation factor 5 0.0275109

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.289508
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.241352
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.138524
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.109836
ACTG1 actin gamma 1 -0.108674
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0828834
LMO7 LIM domain 7 -0.0750881
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.074872
IER3 immediate early response 3 -0.0737388
UBC ubiquitin C -0.0699751
IGFBP3 insulin-like growth factor binding protein 3 -0.0688958
RPS6 ribosomal protein S6 -0.0682611
PTMA prothymosin, alpha -0.0668823
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0620817
RPS23 ribosomal protein S23 -0.0536841
SERINC5 serine incorporator 5 -0.0534007
EGR1 early growth response 1 -0.0516758
RPL34 ribosomal protein L34 -0.0513714
GDF15 growth differentiation factor 15 -0.0496269
RPL8 ribosomal protein L8 -0.0491587
S100A10 S100 calcium binding protein A10 -0.0488626
ANXA1 annexin A1 -0.0484248
ITPRID2 ITPR interacting domain containing 2 -0.0474325
EEF2 eukaryotic translation elongation factor 2 -0.0463666
HDAC2 histone deacetylase 2 -0.0452462
MT1X metallothionein 1X -0.0434442
TMSB10 thymosin beta 10 -0.0434326
HILPDA hypoxia inducible lipid droplet-associated -0.0423864
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.041498
LOC112694756 uncharaterized LOC112694756 -0.0413121
DIAPH2 diaphanous-related formin 2 -0.0403477
GLG1 golgi glycoprotein 1 -0.0396545
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0385263
FN1 fibronectin 1 -0.0377776
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0376721
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0367421
TPT1 tumor protein, translationally-controlled 1 -0.036736
RPLP0 ribosomal protein, large, P0 -0.0360892
FTH1 ferritin, heavy polypeptide 1 -0.0351065
NDRG1 N-myc downstream regulated 1 -0.0345427
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.03433
RPS24 ribosomal protein S24 -0.0342615
ATP5F1B ATP synthase F1 subunit beta -0.0339387
YBX1 Y box binding protein 1 -0.0336823
BAMBI BMP and activin membrane-bound inhibitor -0.0334385
VCL vinculin -0.0330776
RPL35A ribosomal protein L35a -0.0328631
TXNIP thioredoxin interacting protein -0.0322073
RPS15 ribosomal protein S15 -0.0322054
ZBTB7C zinc finger and BTB domain containing 7C -0.0318393
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0317913
JARID2 jumonji, AT rich interactive domain 2 -0.0317582
ACTN4 actinin, alpha 4 -0.0308216
EFNA5 ephrin-A5 -0.0305176
GMDS GDP-mannose 4,6-dehydratase -0.0304656
FOXO1 forkhead box O1 -0.0303627
LDHA lactate dehydrogenase A -0.0301728
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0295127
S100A9 S100 calcium binding protein A9 -0.0287791
CANX calnexin -0.0287089
H1-0 H1.0 linker histone -0.0286857
HMGB1 high mobility group box 1 -0.0284319
ARF1 ADP-ribosylation factor 1 -0.0280755
TUBB tubulin, beta class I -0.0270994
RPL32 ribosomal protein L32 -0.0270785
KRT8 keratin 8, type II -0.0270279
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0270086
ASPH aspartate beta-hydroxylase -0.0265771
DSPP dentin sialophosphoprotein -0.0264748
POTEF POTE ankyrin domain family, member F -0.0263971
PDE4D phosphodiesterase 4D, cAMP-specific -0.0263529
BCL2L1 BCL2-like 1 -0.0257332
YOD1 YOD1 deubiquitinase -0.0255175
AOPEP aminopeptidase O (putative) -0.0253655
CD36 CD36 molecule (thrombospondin receptor) -0.025149
RPS5 ribosomal protein S5 -0.0251216
RREB1 ras responsive element binding protein 1 -0.0249714
PDIA4 protein disulfide isomerase family A, member 4 -0.0244854
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0243572
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0242417
IARS1 isoleucyl-tRNA synthetase 1 -0.0241698
H3-3B H3.3 histone B -0.024141
RSL1D1 ribosomal L1 domain containing 1 -0.023743
RPS11 ribosomal protein S11 -0.0235649
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0232768
INSIG1 insulin induced gene 1 -0.0232707
CAMKMT calmodulin-lysine N-methyltransferase -0.0232183
MYO5B myosin VB -0.0232007
DEK DEK proto-oncogene -0.0231398
RPL4 ribosomal protein L4 -0.0229637
TRAF3 TNF receptor-associated factor 3 -0.022656
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0223095
RHOA ras homolog family member A -0.0219274
KLF3 Kruppel-like factor 3 (basic) -0.0218807
FTL ferritin, light polypeptide -0.021791
ZFP36L1 ZFP36 ring finger protein-like 1 -0.02161
DSG2 desmoglein 2 -0.0216063
NFIA nuclear factor I/A -0.0213341
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0212325
ZNRF3 zinc and ring finger 3 -0.0210839