| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A benzothiophene that has formula C28H27NO4S. (Chemical Entities of Biological Interest Ontology, CHEBI_8772) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5035 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Raloxifene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 1.76 |
| SQLE | squalene epoxidase | 1.41 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.29 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.28 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.27 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.26 |
| MSMO1 | methylsterol monooxygenase 1 | 1.24 |
| CD63 | CD63 molecule | 1.11 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 1.11 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.07 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.96 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | 0.93 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 0.92 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.89 |
| PLPP2 | phospholipid phosphatase 2 | 0.88 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.84 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.83 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.83 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.8 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.78 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.77 |
| TTYH2 | tweety family member 2 | 0.75 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.75 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.74 |
| NCOA4 | nuclear receptor coactivator 4 | 0.74 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.72 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.7 |
| RUBCN | rubicon autophagy regulator | 0.7 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.7 |
| MVK | mevalonate kinase | 0.68 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.67 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.67 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.67 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.66 |
| RNF26 | ring finger protein 26 | 0.63 |
| LDLR | low density lipoprotein receptor | 0.62 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.61 |
| FAR1 | fatty acyl CoA reductase 1 | 0.6 |
| SEC24D | SEC24 family member D | 0.6 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.6 |
| TMEM104 | transmembrane protein 104 | 0.59 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.58 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.58 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.58 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.57 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.57 |
| MT2A | metallothionein 2A | 0.56 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.55 |
| PRKCH | protein kinase C, eta | 0.55 |
| GRAMD2B | GRAM domain containing 2B | 0.55 |
| ABHD3 | abhydrolase domain containing 3 | 0.53 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.53 |
| MLF1 | myeloid leukemia factor 1 | 0.53 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.53 |
| NPNT | nephronectin | 0.52 |
| TMEM40 | transmembrane protein 40 | 0.51 |
| PDGFC | platelet derived growth factor C | 0.51 |
| FADS1 | fatty acid desaturase 1 | 0.51 |
| MCL1 | myeloid cell leukemia 1 | 0.51 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.51 |
| MCOLN1 | mucolipin 1 | 0.51 |
| DOCK10 | dedicator of cytokinesis 10 | 0.5 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | 0.5 |
| SARDH | sarcosine dehydrogenase | 0.5 |
| TMEM106B | transmembrane protein 106B | 0.5 |
| KANK3 | KN motif and ankyrin repeat domains 3 | 0.5 |
| ITM2C | integral membrane protein 2C | 0.5 |
| ITM2B | integral membrane protein 2B | 0.49 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.49 |
| MT1X | metallothionein 1X | 0.48 |
| ATXN1L | ataxin 1-like | 0.48 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.48 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.47 |
| LPIN1 | lipin 1 | 0.47 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.47 |
| SPATA13 | spermatogenesis associated 13 | 0.46 |
| SLC10A4 | solute carrier family 10, member 4 | 0.46 |
| MVD | mevalonate (diphospho) decarboxylase | 0.45 |
| COBL | cordon-bleu WH2 repeat protein | 0.45 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.44 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.44 |
| FJX1 | four jointed box 1 (Drosophila) | 0.44 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.44 |
| SCARB1 | scavenger receptor class B, member 1 | 0.43 |
| TMX2 | thioredoxin-related transmembrane protein 2 | 0.43 |
| TSPAN5 | tetraspanin 5 | 0.42 |
| ZNF600 | zinc finger protein 600 | 0.42 |
| TMEM41B | transmembrane protein 41B | 0.42 |
| MT1E | metallothionein 1E | 0.42 |
| SLC38A2 | solute carrier family 38, member 2 | 0.42 |
| TSKU | tsukushi, small leucine rich proteoglycan | 0.42 |
| RNF149 | ring finger protein 149 | 0.41 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.41 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.41 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.41 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.41 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 0.41 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.4 |
| ADCK5 | aarF domain containing kinase 5 | 0.4 |
| ACYP2 | acylphosphatase 2, muscle type | 0.4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -2.4 |
| SYTL2 | synaptotagmin-like 2 | -1.47 |
| COL17A1 | collagen, type XVII, alpha 1 | -1.43 |
| FANCF | Fanconi anemia, complementation group F | -1.35 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -1.14 |
| FBXW4 | F-box and WD repeat domain containing 4 | -1.09 |
| OSCP1 | organic solute carrier partner 1 | -1.0 |
| TMEM97 | transmembrane protein 97 | -0.97 |
| ARG2 | arginase 2 | -0.82 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.78 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.75 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.75 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.73 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.72 |
| COL1A1 | collagen, type I, alpha 1 | -0.64 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.63 |
| TMC5 | transmembrane channel-like 5 | -0.63 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.6 |
| TRIM29 | tripartite motif containing 29 | -0.57 |
| H3C1 | H3 clustered histone 1 | -0.56 |
| TSPAN31 | tetraspanin 31 | -0.56 |
| SELENOH | selenoprotein H | -0.55 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.54 |
| HYAL2 | hyaluronoglucosaminidase 2 | -0.54 |
| THAP9 | THAP domain containing 9 | -0.53 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.51 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.51 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.51 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.49 |
| CERK | ceramide kinase | -0.48 |
| FGB | fibrinogen beta chain | -0.48 |
| CES2 | carboxylesterase 2 | -0.47 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.47 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.46 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.45 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.44 |
| ZNF395 | zinc finger protein 395 | -0.43 |
| CTSC | cathepsin C | -0.43 |
| ABHD17A | abhydrolase domain containing 17A | -0.42 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.41 |
| DPP7 | dipeptidyl-peptidase 7 | -0.4 |
| PROS1 | protein S (alpha) | -0.4 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.4 |
| CABLES2 | Cdk5 and Abl enzyme substrate 2 | -0.4 |
| SP100 | SP100 nuclear antigen | -0.4 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.4 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -0.4 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.4 |
| ENO1 | enolase 1, (alpha) | -0.4 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.39 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.39 |
| LNX2 | ligand of numb-protein X 2 | -0.39 |
| TP53 | tumor protein p53 | -0.38 |
| TRO | trophinin | -0.38 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | -0.37 |
| UBTD1 | ubiquitin domain containing 1 | -0.37 |
| GM2A | GM2 ganglioside activator | -0.37 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -0.37 |
| CPA4 | carboxypeptidase A4 | -0.37 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.36 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.36 |
| FAM162A | family with sequence similarity 162, member A | -0.36 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.36 |
| ADIPOR1 | adiponectin receptor 1 | -0.36 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | -0.35 |
| ADIRF | adipogenesis regulatory factor | -0.35 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.35 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.34 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.34 |
| RPL26 | ribosomal protein L26 | -0.33 |
| H1-2 | H1.2 linker histone, cluster member | -0.33 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.33 |
| WLS | wntless Wnt ligand secretion mediator | -0.33 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -0.32 |
| ZNF564 | zinc finger protein 564 | -0.32 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.32 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.32 |
| PGPEP1 | pyroglutamyl-peptidase I | -0.32 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.31 |
| ZNF354B | zinc finger protein 354B | -0.31 |
| PLIN2 | perilipin 2 | -0.31 |
| ARSD | arylsulfatase D | -0.31 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.31 |
| DENND4B | DENN/MADD domain containing 4B | -0.31 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.31 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.3 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.3 |
| ANGPTL4 | angiopoietin-like 4 | -0.3 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.3 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.3 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.29 |
| RIOK3 | RIO kinase 3 | -0.29 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.29 |
| PTMA | prothymosin, alpha | -0.29 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.29 |
| S100A6 | S100 calcium binding protein A6 | -0.29 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.29 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.29 |
| ARL6IP4 | ADP-ribosylation factor-like 6 interacting protein 4 | -0.28 |
| ARSK | arylsulfatase family, member K | -0.28 |
