| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PODXL | podocalyxin-like | 0.232484 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.21828 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.201854 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.156278 |
| FLNB | filamin B, beta | 0.115182 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0989223 |
| NAV2 | neuron navigator 2 | 0.0850542 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.080744 |
| SEPTIN9 | septin 9 | 0.0721693 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0648488 |
| NDRG1 | N-myc downstream regulated 1 | 0.0645487 |
| TPM3 | tropomyosin 3 | 0.0641582 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0634342 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0623036 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0570871 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0563115 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0536368 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0533542 |
| RUNX1 | runt-related transcription factor 1 | 0.0532818 |
| LOXL2 | lysyl oxidase-like 2 | 0.0505431 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0501016 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0483257 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0479978 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0478013 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0470146 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0464525 |
| SQSTM1 | sequestosome 1 | 0.0455742 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0449378 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0447033 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0437085 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0436399 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0434246 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0425256 |
| FLNA | filamin A, alpha | 0.0423453 |
| CDH13 | cadherin 13 | 0.0415173 |
| ACTG1 | actin gamma 1 | 0.0404904 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0404303 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0401288 |
| PGK1 | phosphoglycerate kinase 1 | 0.0395456 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0394824 |
| RND3 | Rho family GTPase 3 | 0.0392639 |
| FSTL1 | follistatin-like 1 | 0.0391169 |
| ADM | adrenomedullin | 0.0389938 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0389082 |
| ZNF292 | zinc finger protein 292 | 0.0382404 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0380387 |
| OGA | O-GlcNAcase | 0.0378488 |
| PLEC | plectin | 0.0377886 |
| CD109 | CD109 molecule | 0.0375949 |
| FAM107B | family with sequence similarity 107, member B | 0.0375736 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0373006 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0362831 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0361658 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0358995 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0356846 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0354813 |
| CENPF | centromere protein F, 350/400kDa | 0.0353354 |
| HLA-B | major histocompatibility complex, class I, B | 0.0351617 |
| PFKP | phosphofructokinase, platelet | 0.0350008 |
| MSN | moesin | 0.034976 |
| RTN4 | reticulon 4 | 0.0349204 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0347826 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0342044 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0340712 |
| TRAM2 | translocation associated membrane protein 2 | 0.0340305 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0337067 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0332224 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0332058 |
| ARFGEF3 | ARFGEF family member 3 | 0.0330353 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0327251 |
| JUN | jun proto-oncogene | 0.0326566 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0324446 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0317895 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0316203 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0310274 |
| HDAC9 | histone deacetylase 9 | 0.030936 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0308748 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0308461 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0305928 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0303712 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0302659 |
| APP | amyloid beta (A4) precursor protein | 0.0295527 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0294593 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0293893 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0292532 |
| PTK2 | protein tyrosine kinase 2 | 0.0288632 |
| PRELID2 | PRELI domain containing 2 | 0.0286234 |
| HELZ | helicase with zinc finger | 0.0285532 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0283155 |
| ANO6 | anoctamin 6 | 0.0279228 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0279206 |
| DCLK2 | doublecortin-like kinase 2 | 0.0278222 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0277674 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.027765 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0277465 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0276775 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0275608 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0273697 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0270761 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0269306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.252047 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.166316 |
| TMSB10 | thymosin beta 10 | -0.144616 |
| LOX | lysyl oxidase | -0.13493 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0743485 |
| S100A10 | S100 calcium binding protein A10 | -0.0678779 |
| FN1 | fibronectin 1 | -0.0669089 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0653846 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0630366 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0596431 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0496131 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0444609 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0432001 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0424309 |
| FBN1 | fibrillin 1 | -0.0404509 |
| MYADM | myeloid-associated differentiation marker | -0.0396702 |
| COL5A2 | collagen, type V, alpha 2 | -0.0389884 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0377293 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0373849 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0372685 |
| GLIS3 | GLIS family zinc finger 3 | -0.0361681 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0352896 |
| PRSS23 | protease, serine, 23 | -0.0349437 |
| S100A6 | S100 calcium binding protein A6 | -0.0348644 |
| SP100 | SP100 nuclear antigen | -0.0343573 |
| RASAL2 | RAS protein activator like 2 | -0.0339095 |
| VCL | vinculin | -0.0336661 |
| LMNA | lamin A/C | -0.0336208 |
| POTEF | POTE ankyrin domain family, member F | -0.0329717 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.031949 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0318237 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0317124 |
| CYTH3 | cytohesin 3 | -0.0312431 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0304029 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0299664 |
| S100A11 | S100 calcium binding protein A11 | -0.0294169 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0292424 |
| KIFAP3 | kinesin-associated protein 3 | -0.0291482 |
| SUCNR1 | succinate receptor 1 | -0.0288772 |
| COL1A2 | collagen, type I, alpha 2 | -0.0286449 |
| S100A4 | S100 calcium binding protein A4 | -0.0281568 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0277949 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0268871 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0263057 |
| FRMD5 | FERM domain containing 5 | -0.0256125 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0247131 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0246403 |
| MT2A | metallothionein 2A | -0.0245571 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0245181 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0242491 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0239939 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0239473 |
| FRMD4A | FERM domain containing 4A | -0.0237614 |
| LRRC17 | leucine rich repeat containing 17 | -0.0236907 |
| GNAS | GNAS complex locus | -0.0235059 |
| IL7R | interleukin 7 receptor | -0.0232098 |
| EHBP1 | EH domain binding protein 1 | -0.0232088 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0226549 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0226407 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0224012 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0223779 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0221491 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0220132 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0217918 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0216764 |
| B2M | beta-2-microglobulin | -0.0215661 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0209915 |
| CCND1 | cyclin D1 | -0.0207772 |
| NEK7 | NIMA-related kinase 7 | -0.0206304 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.020611 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.02031 |
| VEGFC | vascular endothelial growth factor C | -0.0200154 |
| JAZF1 | JAZF zinc finger 1 | -0.0198849 |
| NRP1 | neuropilin 1 | -0.0198749 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0193877 |
| RC3H2 | ring finger and CCCH-type domains 2 | -0.01923 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.0192105 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.0191517 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0189275 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0189221 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0187614 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0187492 |
| MAP4 | microtubule-associated protein 4 | -0.0187048 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0184098 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0183691 |
| PRRX1 | paired related homeobox 1 | -0.0183545 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0183492 |
| CEP350 | centrosomal protein 350kDa | -0.0181805 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0180607 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0179789 |
| PCNX4 | pecanex 4 | -0.0179531 |
| IPO9 | importin 9 | -0.0178783 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0176982 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0176142 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0173127 |
| AUTS2 | autism susceptibility candidate 2 | -0.0171472 |
| FBXO11 | F-box protein 11 | -0.0171321 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0171045 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0169788 |
| RIGI | RNA sensor RIG-I | -0.0166914 |
