| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10699 |
| AREG | amphiregulin | 0.102475 |
| TPM3 | tropomyosin 3 | 0.0801436 |
| CCN2 | cellular communication network factor 2 | 0.0755548 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0722178 |
| RRM2 | ribonucleotide reductase M2 | 0.0654217 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0652351 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0624989 |
| PCBP2 | poly(rC) binding protein 2 | 0.0616648 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0613902 |
| VMP1 | vacuole membrane protein 1 | 0.0569906 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0568636 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.053087 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0495684 |
| ACTG1 | actin gamma 1 | 0.0469594 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0446959 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.043284 |
| RTN4 | reticulon 4 | 0.0431907 |
| CCNL1 | cyclin L1 | 0.0431906 |
| EGR1 | early growth response 1 | 0.0429169 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.040585 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0404971 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.038613 |
| JMJD1C | jumonji domain containing 1C | 0.0382585 |
| BRD2 | bromodomain containing 2 | 0.0372136 |
| MAP1B | microtubule-associated protein 1B | 0.0366273 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0365071 |
| YBX1 | Y box binding protein 1 | 0.0363004 |
| SON | SON DNA binding protein | 0.0349501 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0349468 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0344295 |
| SETD5 | SET domain containing 5 | 0.0339827 |
| HLA-A | major histocompatibility complex, class I, A | 0.0338499 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0335722 |
| ATP11A | ATPase, class VI, type 11A | 0.0330292 |
| CPOX | coproporphyrinogen oxidase | 0.0327753 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0322133 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0320878 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0320446 |
| ZNF638 | zinc finger protein 638 | 0.031228 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0309099 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0305964 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0304837 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0302895 |
| MMP12 | matrix metallopeptidase 12 | 0.0294685 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0293955 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0289228 |
| YAP1 | Yes-associated protein 1 | 0.0287178 |
| PCM1 | pericentriolar material 1 | 0.0286063 |
| TPI1 | triosephosphate isomerase 1 | 0.0281504 |
| RAD51B | RAD51 paralog B | 0.0275414 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0274655 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0272692 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0272157 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0271462 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0270891 |
| LOC112694756 | uncharaterized LOC112694756 | 0.026962 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0269532 |
| EZR | ezrin | 0.0266039 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0265162 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.026336 |
| MED13L | mediator complex subunit 13-like | 0.0262639 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.02616 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.02603 |
| PGK1 | phosphoglycerate kinase 1 | 0.0258223 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0257327 |
| PRRC2A | proline-rich coiled-coil 2A | 0.025611 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0255125 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0252104 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0251616 |
| YEATS2 | YEATS domain containing 2 | 0.0250669 |
| POTEF | POTE ankyrin domain family, member F | 0.0248437 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0248372 |
| TBK1 | TANK-binding kinase 1 | 0.024489 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0244299 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0242381 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0238634 |
| CEP192 | centrosomal protein 192kDa | 0.0236802 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0233971 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0233587 |
| RPS12 | ribosomal protein S12 | 0.0232382 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0231062 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0228619 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0228438 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0228032 |
| PFN1 | profilin 1 | 0.0226687 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0226646 |
| RPS6 | ribosomal protein S6 | 0.0223171 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0222728 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0222246 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.022213 |
| SPAG9 | sperm associated antigen 9 | 0.0220568 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0218729 |
| ECT2 | epithelial cell transforming 2 | 0.0216906 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.021597 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0215466 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0214907 |
| UBC | ubiquitin C | 0.0213857 |
| EPHA6 | EPH receptor A6 | 0.0213042 |
| ZNF292 | zinc finger protein 292 | 0.0211925 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.222465 |
| NLGN1 | neuroligin 1 | -0.155909 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.128837 |
| PCDH7 | protocadherin 7 | -0.0828386 |
| CLDN1 | claudin 1 | -0.0664161 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0619804 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0606781 |
| ZNF804A | zinc finger protein 804A | -0.0578883 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0573873 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0543966 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0540571 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0524439 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0500042 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0493532 |
| HMGA2 | high mobility group AT-hook 2 | -0.0485856 |
| RASAL2 | RAS protein activator like 2 | -0.0465931 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0464099 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0461101 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0458078 |
| BCHE | butyrylcholinesterase | -0.0443931 |
| MTAP | methylthioadenosine phosphorylase | -0.0443797 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0433824 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0433588 |
| CCND1 | cyclin D1 | -0.0370614 |
| RPS24 | ribosomal protein S24 | -0.03405 |
| TMSB10 | thymosin beta 10 | -0.0337791 |
| PTMA | prothymosin, alpha | -0.0337315 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.030926 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0305183 |
| GNAS | GNAS complex locus | -0.0304072 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0303036 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0295046 |
| EHBP1 | EH domain binding protein 1 | -0.0289702 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0257967 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0252986 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.025032 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0248113 |
| TMEM123 | transmembrane protein 123 | -0.0242175 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0239858 |
| FSTL5 | follistatin-like 5 | -0.0221139 |
| TMEM131 | transmembrane protein 131 | -0.0215974 |
| TENM3 | teneurin transmembrane protein 3 | -0.0215542 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0214065 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0209492 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0209169 |
| RACK1 | receptor for activated C kinase 1 | -0.0203061 |
| KPNB1 | karyopherin (importin) beta 1 | -0.020292 |
| PCDH9 | protocadherin 9 | -0.020251 |
| BRI3BP | BRI3 binding protein | -0.0201389 |
| RPL35A | ribosomal protein L35a | -0.0198722 |
| RPL34 | ribosomal protein L34 | -0.0198363 |
| S100A10 | S100 calcium binding protein A10 | -0.019615 |
| HMGA1 | high mobility group AT-hook 1 | -0.0194843 |
| CDK6 | cyclin-dependent kinase 6 | -0.0194396 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0190601 |
| ANXA1 | annexin A1 | -0.0190064 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0189783 |
| INTS6 | integrator complex subunit 6 | -0.0189389 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0189169 |
| NAV3 | neuron navigator 3 | -0.018802 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0185955 |
| ASPH | aspartate beta-hydroxylase | -0.0185108 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0184837 |
| AK1 | adenylate kinase 1 | -0.0183557 |
| DIAPH2 | diaphanous-related formin 2 | -0.0179584 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0179387 |
| EGFR | epidermal growth factor receptor | -0.0178709 |
| S100A6 | S100 calcium binding protein A6 | -0.0178229 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0175958 |
| VCAN | versican | -0.0174932 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0172104 |
| RPL38 | ribosomal protein L38 | -0.0169096 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0161328 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0160706 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0159336 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0156819 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0156141 |
| ZNF519 | zinc finger protein 519 | -0.0153358 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0153064 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0151575 |
| KLF6 | Kruppel-like factor 6 | -0.0149674 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0148543 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0148262 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0147904 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.014734 |
| EPCAM | epithelial cell adhesion molecule | -0.0144065 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0143915 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0143357 |
| ZFR | zinc finger RNA binding protein | -0.0142817 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.014181 |
| LMO7 | LIM domain 7 | -0.0139991 |
| AHNAK | AHNAK nucleoprotein | -0.0139968 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.0139371 |
| FBXO27 | F-box protein 27 | -0.0138886 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0135343 |
| FAM110C | family with sequence similarity 110, member C | -0.013441 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0133037 |
| EPHA5 | EPH receptor A5 | -0.0132949 |
| RPL6 | ribosomal protein L6 | -0.0131033 |
| COMMD10 | COMM domain containing 10 | -0.0130623 |
