| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.182097 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.142644 |
| FMN1 | formin 1 | 0.14085 |
| LSAMP | limbic system-associated membrane protein | 0.134636 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.100481 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0998038 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0787264 |
| ACTG1 | actin gamma 1 | 0.0779641 |
| RNF213 | ring finger protein 213 | 0.0682398 |
| PLPP1 | phospholipid phosphatase 1 | 0.0656515 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0603681 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0581548 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0557678 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.055599 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0553119 |
| BPTF | bromodomain PHD finger transcription factor | 0.0545211 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0534144 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0531777 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0529772 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0526676 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0520416 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0515485 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0514175 |
| MEIS2 | Meis homeobox 2 | 0.0507763 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.050709 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0479755 |
| MMP2 | matrix metallopeptidase 2 | 0.0477948 |
| CRH | corticotropin releasing hormone | 0.0466227 |
| COL1A1 | collagen, type I, alpha 1 | 0.0465609 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0464378 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.0457663 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0456423 |
| PLAT | plasminogen activator, tissue | 0.0447842 |
| PCBP3 | poly(rC) binding protein 3 | 0.0439288 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0434937 |
| SEPTIN9 | septin 9 | 0.0434203 |
| RGS5 | regulator of G-protein signaling 5 | 0.0433458 |
| AOPEP | aminopeptidase O (putative) | 0.0416085 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0415896 |
| FRMD4A | FERM domain containing 4A | 0.0409717 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0408275 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0399205 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0394723 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0382036 |
| GLCCI1 | glucocorticoid induced 1 | 0.0379088 |
| EGR1 | early growth response 1 | 0.0378524 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0378052 |
| TENM4 | teneurin transmembrane protein 4 | 0.0376169 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0367974 |
| PRKCA | protein kinase C, alpha | 0.0362496 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0346595 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0343946 |
| NBEA | neurobeachin | 0.0342681 |
| MSI2 | musashi RNA-binding protein 2 | 0.0340308 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0337354 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0334983 |
| B2M | beta-2-microglobulin | 0.0329644 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.032482 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.032286 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0318276 |
| TLE4 | transducin-like enhancer of split 4 | 0.0317361 |
| FAM107B | family with sequence similarity 107, member B | 0.0317356 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0315869 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0312722 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0311335 |
| RPL23 | ribosomal protein L23 | 0.0310574 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0307471 |
| CTSB | cathepsin B | 0.0306957 |
| CALD1 | caldesmon 1 | 0.0305827 |
| SSH2 | slingshot protein phosphatase 2 | 0.0305291 |
| CALU | calumenin | 0.0301289 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0301124 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0300675 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0295206 |
| SMYD3 | SET and MYND domain containing 3 | 0.029274 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0285737 |
| DISC1 | disrupted in schizophrenia 1 | 0.0283645 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0283417 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0281452 |
| MAPK10 | mitogen-activated protein kinase 10 | 0.0281002 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0280949 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0280635 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.027999 |
| DUSP16 | dual specificity phosphatase 16 | 0.0278777 |
| RGS4 | regulator of G-protein signaling 4 | 0.0278719 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.027509 |
| AMOTL1 | angiomotin like 1 | 0.0270974 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0265716 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0264381 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0263187 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0261113 |
| TRIM24 | tripartite motif containing 24 | 0.0260841 |
| FNBP1 | formin binding protein 1 | 0.0260004 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0257748 |
| RPL4 | ribosomal protein L4 | 0.0257485 |
| KLHL13 | kelch-like family member 13 | 0.0257349 |
| SIK2 | salt-inducible kinase 2 | 0.025677 |
| TCF12 | transcription factor 12 | 0.025649 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0255294 |
| JMJD1C | jumonji domain containing 1C | 0.0252591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.456629 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0925569 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0523213 |
| PTMA | prothymosin, alpha | -0.0463222 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0459012 |
| LPIN1 | lipin 1 | -0.0444274 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0440737 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0429548 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0425599 |
| PTK2 | protein tyrosine kinase 2 | -0.0421135 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0385414 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0357726 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0356209 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0352866 |
| HELZ | helicase with zinc finger | -0.0350177 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0349482 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0349206 |
| NEK7 | NIMA-related kinase 7 | -0.0345509 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0340002 |
| RTN4 | reticulon 4 | -0.0328467 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0320462 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0296739 |
| TRIB2 | tribbles pseudokinase 2 | -0.0293738 |
| CENPE | centromere protein E, 312kDa | -0.0292898 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0291558 |
| CENPF | centromere protein F, 350/400kDa | -0.0291206 |
| HMGA1 | high mobility group AT-hook 1 | -0.0286144 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0282871 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0281624 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0280882 |
| SPAG9 | sperm associated antigen 9 | -0.0279837 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0276185 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0275714 |
| DPH6 | diphthamine biosynthesis 6 | -0.027388 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0270482 |
| FOXK2 | forkhead box K2 | -0.0270377 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0270073 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0269912 |
| MAP1B | microtubule-associated protein 1B | -0.026912 |
| RPS25 | ribosomal protein S25 | -0.0265207 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0263092 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.026227 |
| NRG1 | neuregulin 1 | -0.0260919 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0260243 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0257065 |
| ODR4 | odr-4 GPCR localization factor homolog | -0.0253357 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0251757 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.025127 |
| RPS24 | ribosomal protein S24 | -0.0250559 |
| ASPH | aspartate beta-hydroxylase | -0.0248178 |
| NUP153 | nucleoporin 153kDa | -0.0244566 |
| QKI | QKI, KH domain containing, RNA binding | -0.0241887 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0241218 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0238396 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0234928 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0234008 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0230165 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0228749 |
| SLMAP | sarcolemma associated protein | -0.0226976 |
| MTDH | metadherin | -0.0225902 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0224873 |
| PAPOLA | poly(A) polymerase alpha | -0.0224838 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0224769 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0224465 |
| NDRG1 | N-myc downstream regulated 1 | -0.022394 |
| SRPK2 | SRSF protein kinase 2 | -0.0222428 |
| RPL38 | ribosomal protein L38 | -0.022096 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0218443 |
| DTNA | dystrobrevin, alpha | -0.0217775 |
| RFX7 | regulatory factor X, 7 | -0.0216892 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0216628 |
| HMGA2 | high mobility group AT-hook 2 | -0.0215854 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0213462 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0208736 |
| ZNF292 | zinc finger protein 292 | -0.0207941 |
| LMNA | lamin A/C | -0.0207716 |
| TMF1 | TATA element modulatory factor 1 | -0.0207464 |
| ZNF207 | zinc finger protein 207 | -0.0207024 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0206722 |
| RPS2 | ribosomal protein S2 | -0.0206179 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0205824 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0205129 |
| DIAPH3 | diaphanous-related formin 3 | -0.020369 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0202744 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0202596 |
| MKI67 | marker of proliferation Ki-67 | -0.0201379 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0199806 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0199574 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0199321 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0198034 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0197938 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.019728 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0197171 |
| ANXA2 | annexin A2 | -0.0197099 |
| FOXP1 | forkhead box P1 | -0.0195898 |
| UBXN7 | UBX domain protein 7 | -0.0195888 |
| RBMX | RNA binding motif protein, X-linked | -0.0194713 |
| ERBIN | erbb2 interacting protein | -0.0194142 |
| TLK1 | tousled-like kinase 1 | -0.0194115 |
| CDH13 | cadherin 13 | -0.0193174 |
