| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 0.260964 |
| LMO7 | LIM domain 7 | 0.159963 |
| EXT1 | exostosin glycosyltransferase 1 | 0.11172 |
| ACTG1 | actin gamma 1 | 0.102865 |
| B2M | beta-2-microglobulin | 0.095401 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.089756 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0873813 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0737192 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0706491 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0685023 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0668142 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.065753 |
| RIGI | RNA sensor RIG-I | 0.0622212 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0622052 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0601097 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.059413 |
| HLA-B | major histocompatibility complex, class I, B | 0.0592468 |
| EGR1 | early growth response 1 | 0.0589542 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0587205 |
| HLA-A | major histocompatibility complex, class I, A | 0.0575376 |
| MCL1 | myeloid cell leukemia 1 | 0.0568724 |
| TJP1 | tight junction protein 1 | 0.0565465 |
| DIAPH1 | diaphanous-related formin 1 | 0.0558299 |
| BCL2L1 | BCL2-like 1 | 0.0548306 |
| SMAD3 | SMAD family member 3 | 0.0542184 |
| MX2 | MX dynamin-like GTPase 2 | 0.0538233 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0535533 |
| ERBIN | erbb2 interacting protein | 0.0517035 |
| MYO1E | myosin IE | 0.0504179 |
| AREG | amphiregulin | 0.050125 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0498493 |
| RNF213 | ring finger protein 213 | 0.0465622 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0463241 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0449094 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0447465 |
| PGK1 | phosphoglycerate kinase 1 | 0.0424677 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0416972 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0411677 |
| MT2A | metallothionein 2A | 0.040367 |
| EZR | ezrin | 0.0402957 |
| TMSB10 | thymosin beta 10 | 0.0392225 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0384221 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0379471 |
| FAT1 | FAT atypical cadherin 1 | 0.0376312 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0374851 |
| STK24 | serine/threonine kinase 24 | 0.0374815 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0373647 |
| TPM3 | tropomyosin 3 | 0.0370318 |
| MCU | mitochondrial calcium uniporter | 0.0361412 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0358863 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0356894 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0352565 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0344646 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0343463 |
| DUSP10 | dual specificity phosphatase 10 | 0.0341393 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0340349 |
| MUC13 | mucin 13, cell surface associated | 0.0336163 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0334619 |
| FTL | ferritin, light polypeptide | 0.0333898 |
| TMC5 | transmembrane channel-like 5 | 0.0331427 |
| KYNU | kynureninase | 0.0330478 |
| FHL2 | four and a half LIM domains 2 | 0.0326936 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0325788 |
| SEPTIN9 | septin 9 | 0.0324558 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0321355 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0319025 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0317206 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0311893 |
| EFNB2 | ephrin-B2 | 0.0311457 |
| ANXA11 | annexin A11 | 0.031058 |
| ATP10B | ATPase, class V, type 10B | 0.0309812 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0305282 |
| MLPH | melanophilin | 0.0302348 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0302199 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.030055 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.029878 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0297523 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0296928 |
| VMP1 | vacuole membrane protein 1 | 0.0292817 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0292813 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0292627 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0292359 |
| TRIB1 | tribbles pseudokinase 1 | 0.0289789 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0287308 |
| JUN | jun proto-oncogene | 0.0285899 |
| RND3 | Rho family GTPase 3 | 0.028498 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0283946 |
| KRT18 | keratin 18, type I | 0.0282816 |
| HLA-C | major histocompatibility complex, class I, C | 0.0282204 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0281349 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.027914 |
| EPHA2 | EPH receptor A2 | 0.0278815 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0277298 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0276298 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0272464 |
| TMEM65 | transmembrane protein 65 | 0.0266498 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0266093 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0262544 |
| SQSTM1 | sequestosome 1 | 0.0262173 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0260218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.190058 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144553 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.107708 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0951589 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0886089 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0711983 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0708218 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0703522 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0689172 |
| LYZ | lysozyme | -0.0659345 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0653828 |
| NDRG1 | N-myc downstream regulated 1 | -0.0627628 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0609429 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0604446 |
| RUNX1 | runt-related transcription factor 1 | -0.0565692 |
| H1-0 | H1.0 linker histone | -0.0547119 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.053096 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0527387 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0474314 |
| CANX | calnexin | -0.0470724 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0468405 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0465982 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0446623 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0438775 |
| MECOM | MDS1 and EVI1 complex locus | -0.0429596 |
| PHF3 | PHD finger protein 3 | -0.0425692 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0422352 |
| RBM39 | RNA binding motif protein 39 | -0.0421726 |
| HDLBP | high density lipoprotein binding protein | -0.0403858 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0401506 |
| MKI67 | marker of proliferation Ki-67 | -0.0401102 |
| PTMA | prothymosin, alpha | -0.0396989 |
| DIAPH3 | diaphanous-related formin 3 | -0.0393003 |
| WDR45B | WD repeat domain 45B | -0.0388563 |
| AHNAK | AHNAK nucleoprotein | -0.0386479 |
| NF1 | neurofibromin 1 | -0.0383055 |
| GNAS | GNAS complex locus | -0.0375901 |
| MUC20 | mucin 20, cell surface associated | -0.0373473 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0372586 |
| DSPP | dentin sialophosphoprotein | -0.0370559 |
| GOLGB1 | golgin B1 | -0.0367718 |
| CEP350 | centrosomal protein 350kDa | -0.0362912 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0353253 |
| NCKAP5 | NCK-associated protein 5 | -0.0349343 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0346104 |
| MED13 | mediator complex subunit 13 | -0.0344442 |
| SSH2 | slingshot protein phosphatase 2 | -0.0340482 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0338979 |
| ZNF207 | zinc finger protein 207 | -0.0336215 |
| SEC24D | SEC24 family member D | -0.0332968 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.032899 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0317851 |
| ASPH | aspartate beta-hydroxylase | -0.0317155 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0314989 |
| EHF | ets homologous factor | -0.031291 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0312596 |
| NPSR1 | neuropeptide S receptor 1 | -0.0309294 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0307088 |
| ABLIM1 | actin binding LIM protein 1 | -0.0305402 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0305245 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0301813 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0296422 |
| EPCAM | epithelial cell adhesion molecule | -0.02838 |
| AGR2 | anterior gradient 2 | -0.0282803 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0282659 |
| TAOK1 | TAO kinase 1 | -0.0277393 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0277301 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0275649 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0274179 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0272246 |
| CLTC | clathrin, heavy chain (Hc) | -0.0272092 |
| ADD3 | adducin 3 (gamma) | -0.0272001 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0271998 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0271959 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0270883 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0264414 |
| PKM | pyruvate kinase, muscle | -0.0261987 |
| RNF149 | ring finger protein 149 | -0.0261781 |
| TXNIP | thioredoxin interacting protein | -0.0259714 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0258548 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0257734 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0256542 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0255817 |
| MEIS2 | Meis homeobox 2 | -0.0255201 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0255107 |
| HBS1L | HBS1-like translational GTPase | -0.0253702 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.025351 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0253481 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0253289 |
| MSI2 | musashi RNA-binding protein 2 | -0.0252268 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0252004 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.025187 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0248167 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0245495 |
| CENPF | centromere protein F, 350/400kDa | -0.023947 |
| TBPL1 | TBP-like 1 | -0.0237783 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.023775 |
| NUMB | numb homolog (Drosophila) | -0.0235492 |
| FNIP1 | folliculin interacting protein 1 | -0.0234092 |
| GOLGA2 | golgin A2 | -0.0233296 |
