| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.354091 |
| COL6A3 | collagen, type VI, alpha 3 | 0.191203 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.137381 |
| VEGFA | vascular endothelial growth factor A | 0.115186 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.10599 |
| PLEC | plectin | 0.0999406 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0641365 |
| HLA-B | major histocompatibility complex, class I, B | 0.0586007 |
| ACTG1 | actin gamma 1 | 0.0572508 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0547824 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0538909 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0514651 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0503119 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0501382 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0488365 |
| ADM | adrenomedullin | 0.0462559 |
| HLA-A | major histocompatibility complex, class I, A | 0.0429452 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0427325 |
| LOXL2 | lysyl oxidase-like 2 | 0.039724 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0392506 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0390831 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0381704 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0373541 |
| SMAD3 | SMAD family member 3 | 0.0370372 |
| MSN | moesin | 0.0366964 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.035028 |
| PTK2 | protein tyrosine kinase 2 | 0.0343044 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0342745 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0339818 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0335935 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0328625 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0317621 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0315845 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.030868 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0307812 |
| TNS1 | tensin 1 | 0.0298853 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0296512 |
| EGR1 | early growth response 1 | 0.0295627 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0290986 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0290608 |
| B2M | beta-2-microglobulin | 0.0287608 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0282699 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0280033 |
| COPA | coatomer protein complex, subunit alpha | 0.0277527 |
| FLNB | filamin B, beta | 0.0276466 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0273148 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0272466 |
| CALU | calumenin | 0.0271922 |
| MAP1B | microtubule-associated protein 1B | 0.0268052 |
| AXL | AXL receptor tyrosine kinase | 0.0266754 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0265071 |
| FAM107B | family with sequence similarity 107, member B | 0.0264205 |
| FAM219A | family with sequence similarity 219, member A | 0.0261393 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0259729 |
| NAV2 | neuron navigator 2 | 0.0257726 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0253546 |
| RND3 | Rho family GTPase 3 | 0.0252523 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0248843 |
| STC1 | stanniocalcin 1 | 0.0245933 |
| NAV1 | neuron navigator 1 | 0.0244701 |
| TPM3 | tropomyosin 3 | 0.024416 |
| RPN1 | ribophorin I | 0.0242986 |
| FMNL2 | formin-like 2 | 0.0242859 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0239362 |
| MYO9B | myosin IXB | 0.023598 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.023467 |
| PMM2 | phosphomannomutase 2 | 0.0234383 |
| CABIN1 | calcineurin binding protein 1 | 0.022956 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0228489 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0226439 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0222829 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0221808 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0219861 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0219664 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0217881 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0214847 |
| BRD2 | bromodomain containing 2 | 0.0213819 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0213808 |
| NOTCH2 | notch 2 | 0.0213331 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0210563 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0209728 |
| GANAB | glucosidase, alpha; neutral AB | 0.0207852 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0207308 |
| TMF1 | TATA element modulatory factor 1 | 0.0207283 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0206294 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0206285 |
| VMP1 | vacuole membrane protein 1 | 0.020454 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.020361 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0202917 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0202235 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0201524 |
| MRTFA | myocardin related transcription factor A | 0.0200898 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0196243 |
| TPM4 | tropomyosin 4 | 0.0193693 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0192095 |
| BRD4 | bromodomain containing 4 | 0.0189708 |
| HLA-C | major histocompatibility complex, class I, C | 0.0188617 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0188554 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0187808 |
| CCNY | cyclin Y | 0.0186768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.379688 |
| VIM | vimentin | -0.142471 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0971561 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0944884 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0776737 |
| CADM1 | cell adhesion molecule 1 | -0.0771654 |
| LOX | lysyl oxidase | -0.0769908 |
| IER3 | immediate early response 3 | -0.0662885 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0602908 |
| NDRG1 | N-myc downstream regulated 1 | -0.0602773 |
| FN1 | fibronectin 1 | -0.0573313 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0559071 |
| CALD1 | caldesmon 1 | -0.0537115 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0536722 |
| COL5A1 | collagen, type V, alpha 1 | -0.0518441 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0502163 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.049449 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.04823 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0464357 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0455035 |
| COL1A2 | collagen, type I, alpha 2 | -0.0452966 |
| PRELID2 | PRELI domain containing 2 | -0.043949 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0438026 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0434916 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.041949 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0404357 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0401383 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0389 |
| ANXA2 | annexin A2 | -0.0379202 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0373076 |
| FRMD4A | FERM domain containing 4A | -0.0369079 |
| GLIS3 | GLIS family zinc finger 3 | -0.0355438 |
| ENO1 | enolase 1, (alpha) | -0.0352868 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0348185 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0346102 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0345054 |
| CNTN5 | contactin 5 | -0.0330182 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0326521 |
| DST | dystonin | -0.0325537 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0315403 |
| PDE10A | phosphodiesterase 10A | -0.031174 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0309832 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0309813 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0306274 |
| FTL | ferritin, light polypeptide | -0.0302157 |
| TMSB10 | thymosin beta 10 | -0.0290767 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0288947 |
| RAD21 | RAD21 homolog (S. pombe) | -0.028888 |
| AHNAK | AHNAK nucleoprotein | -0.0281243 |
| POSTN | periostin, osteoblast specific factor | -0.0280122 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.027742 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0273904 |
| CANX | calnexin | -0.0269311 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0269271 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0267515 |
| FBN1 | fibrillin 1 | -0.0264316 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0264043 |
| PTMA | prothymosin, alpha | -0.0263579 |
| HDAC9 | histone deacetylase 9 | -0.0259908 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0257137 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0257085 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0256742 |
| MORF4L2 | mortality factor 4 like 2 | -0.0255453 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0253027 |
| CAVIN1 | caveolae associated protein 1 | -0.0249301 |
| TMEM263 | transmembrane protein 263 | -0.0244926 |
| NREP | neuronal regeneration related protein | -0.0239694 |
| VCL | vinculin | -0.023807 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0235239 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0231723 |
| DGKI | diacylglycerol kinase, iota | -0.0229439 |
| GNAS | GNAS complex locus | -0.0228761 |
| LDHA | lactate dehydrogenase A | -0.0228717 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0228636 |
| RPLP1 | ribosomal protein, large, P1 | -0.0227604 |
| IL6ST | interleukin 6 signal transducer | -0.022164 |
| BNC2 | basonuclin 2 | -0.0221165 |
| QKI | QKI, KH domain containing, RNA binding | -0.0220689 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0219974 |
| CD44 | CD44 molecule (Indian blood group) | -0.0218431 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0217718 |
| SEPTIN7 | septin 7 | -0.0216899 |
| SMYD3 | SET and MYND domain containing 3 | -0.0215157 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.0212558 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.0211086 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0211008 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0210929 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0209574 |
| ZNF207 | zinc finger protein 207 | -0.0206626 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0206127 |
| CDH13 | cadherin 13 | -0.0206 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0201623 |
| RPS8 | ribosomal protein S8 | -0.0199174 |
| TENM1 | teneurin transmembrane protein 1 | -0.0198683 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0196851 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.019308 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0191398 |
| RRBP1 | ribosome binding protein 1 | -0.0190242 |
| RPL35A | ribosomal protein L35a | -0.0186941 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0185263 |
