| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.367974 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.192091 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.154838 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.113781 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.102236 |
| SVIL | supervillin | 0.102103 |
| TNS1 | tensin 1 | 0.0926362 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0793829 |
| FAM107B | family with sequence similarity 107, member B | 0.0783273 |
| FN1 | fibronectin 1 | 0.0763839 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0759162 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0715674 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0667395 |
| PEG3 | paternally expressed 3 | 0.0637465 |
| ACTG1 | actin gamma 1 | 0.0636232 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0624199 |
| RUNX1 | runt-related transcription factor 1 | 0.0586015 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0518365 |
| DSPP | dentin sialophosphoprotein | 0.0494843 |
| FLNB | filamin B, beta | 0.0492048 |
| ATXN1 | ataxin 1 | 0.049012 |
| PLEC | plectin | 0.0488206 |
| KRT8 | keratin 8, type II | 0.0485402 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0482083 |
| LOC112694756 | uncharaterized LOC112694756 | 0.048091 |
| SMAD3 | SMAD family member 3 | 0.0479539 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0464074 |
| ASPH | aspartate beta-hydroxylase | 0.0458178 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0456494 |
| NDRG1 | N-myc downstream regulated 1 | 0.0432308 |
| ATF3 | activating transcription factor 3 | 0.0424467 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0397329 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0388483 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0385546 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0385109 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0381167 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0378917 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.037864 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.037826 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0378119 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.037797 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0372131 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0370658 |
| ARFGEF3 | ARFGEF family member 3 | 0.0366522 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0363845 |
| KRT18 | keratin 18, type I | 0.0362906 |
| FAM13A | family with sequence similarity 13, member A | 0.0358828 |
| FAT1 | FAT atypical cadherin 1 | 0.0355143 |
| TCIM | transcriptional and immune response regulator | 0.0345464 |
| FOXP1 | forkhead box P1 | 0.033033 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.032904 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0320138 |
| VEGFA | vascular endothelial growth factor A | 0.0319893 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.031663 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0310452 |
| RAD51B | RAD51 paralog B | 0.0304477 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0297373 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0296679 |
| MCL1 | myeloid cell leukemia 1 | 0.0296321 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0295935 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0292431 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.029219 |
| CMIP | c-Maf inducing protein | 0.0291119 |
| JUN | jun proto-oncogene | 0.0290821 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0290102 |
| CRY1 | cryptochrome circadian clock 1 | 0.028772 |
| BRD2 | bromodomain containing 2 | 0.0285876 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0284715 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0281293 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0280995 |
| STC2 | stanniocalcin 2 | 0.0279484 |
| TXNRD1 | thioredoxin reductase 1 | 0.0275116 |
| DHFR | dihydrofolate reductase | 0.0272845 |
| VMP1 | vacuole membrane protein 1 | 0.0272797 |
| DUSP6 | dual specificity phosphatase 6 | 0.0271724 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0268732 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0268725 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0264984 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0260242 |
| PGK1 | phosphoglycerate kinase 1 | 0.0259628 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0257682 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0257433 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0255494 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0254485 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0253402 |
| PER2 | period circadian clock 2 | 0.0252457 |
| DTNA | dystrobrevin, alpha | 0.0252215 |
| KRT23 | keratin 23, type I | 0.0248661 |
| HDAC4 | histone deacetylase 4 | 0.0248537 |
| FLNA | filamin A, alpha | 0.0245995 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0242213 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0236822 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0232917 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0231366 |
| RAI14 | retinoic acid induced 14 | 0.0230717 |
| BCL2L1 | BCL2-like 1 | 0.0229593 |
| KIAA1217 | KIAA1217 | 0.0227877 |
| OPTN | optineurin | 0.0224687 |
| PMM2 | phosphomannomutase 2 | 0.0219819 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0217943 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.253235 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.223594 |
| IGF2 | insulin-like growth factor 2 | -0.140725 |
| GPC3 | glypican 3 | -0.101467 |
| APOA2 | apolipoprotein A-II | -0.098235 |
| TRIM26 | tripartite motif containing 26 | -0.0966061 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0877737 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0827555 |
| SLC38A2 | solute carrier family 38, member 2 | -0.081197 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.074489 |
| A2M | alpha-2-macroglobulin | -0.0676126 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0660928 |
| TMEM123 | transmembrane protein 123 | -0.0596171 |
| RBM39 | RNA binding motif protein 39 | -0.0554589 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0535612 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0495134 |
| APOE | apolipoprotein E | -0.0478056 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0464809 |
| LYZ | lysozyme | -0.0460158 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.045889 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0447595 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0432392 |
| RPS24 | ribosomal protein S24 | -0.0411302 |
| MT2A | metallothionein 2A | -0.0389455 |
| ITGAV | integrin, alpha V | -0.0378273 |
| RPS6 | ribosomal protein S6 | -0.0377478 |
| FTL | ferritin, light polypeptide | -0.0375877 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0375676 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0372776 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0359924 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0351714 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0349988 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0349712 |
| CPE | carboxypeptidase E | -0.0346562 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.034163 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0336746 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0319462 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0317538 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0311078 |
| CFB | complement factor B | -0.0305727 |
| MRTFA | myocardin related transcription factor A | -0.0305562 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0304944 |
| PEG10 | paternally expressed 10 | -0.0302419 |
| CP | ceruloplasmin (ferroxidase) | -0.0297893 |
| C3 | complement component 3 | -0.0295031 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0294535 |
| SDC4 | syndecan 4 | -0.0290458 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0289457 |
| PTMA | prothymosin, alpha | -0.0282804 |
| RPLP1 | ribosomal protein, large, P1 | -0.0280951 |
| RPL5 | ribosomal protein L5 | -0.0280506 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0276176 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0275308 |
| GNAS | GNAS complex locus | -0.0274601 |
| UBXN4 | UBX domain protein 4 | -0.0273761 |
| RPS19 | ribosomal protein S19 | -0.0272651 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0267903 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0261852 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0261793 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0261207 |
| GDF15 | growth differentiation factor 15 | -0.0257142 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0253773 |
| RBM25 | RNA binding motif protein 25 | -0.0253214 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0252758 |
| MATN3 | matrilin 3 | -0.0250882 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0249871 |
| EHBP1 | EH domain binding protein 1 | -0.0247819 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0247189 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0246537 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0245096 |
| PERP | PERP, TP53 apoptosis effector | -0.0241899 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0241846 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0239892 |
| RPLP2 | ribosomal protein, large, P2 | -0.0235897 |
| RPS2 | ribosomal protein S2 | -0.023575 |
| NPR2 | natriuretic peptide receptor 2 | -0.0233761 |
| RPS8 | ribosomal protein S8 | -0.023283 |
| APOC1 | apolipoprotein C-I | -0.0231998 |
| RPL37A | ribosomal protein L37a | -0.0231909 |
| ITGA1 | integrin, alpha 1 | -0.0230532 |
| ZNF207 | zinc finger protein 207 | -0.0227135 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0226743 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0225449 |
| RPL12 | ribosomal protein L12 | -0.0225165 |
| VCL | vinculin | -0.0221913 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0219041 |
| TMSB10 | thymosin beta 10 | -0.0217122 |
| HMGA1 | high mobility group AT-hook 1 | -0.0214379 |
| EPCAM | epithelial cell adhesion molecule | -0.0213885 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0211111 |
| FGG | fibrinogen gamma chain | -0.0209418 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0208987 |
| CST3 | cystatin C | -0.0207719 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0205022 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0204514 |
| MALT1 | MALT1 paracaspase | -0.0204148 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0203209 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0202937 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0201786 |
| SELENOP | selenoprotein P | -0.0198964 |
