| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEC | plectin | 0.102056 |
| TGM2 | transglutaminase 2 | 0.09883 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0971857 |
| BLCAP | bladder cancer associated protein | 0.0929074 |
| PODXL | podocalyxin-like | 0.075079 |
| MEF2A | myocyte enhancer factor 2A | 0.0725585 |
| BCL2L1 | BCL2-like 1 | 0.0711638 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0708235 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0683011 |
| AOPEP | aminopeptidase O (putative) | 0.068147 |
| CLU | clusterin | 0.0591196 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0587959 |
| SMAD3 | SMAD family member 3 | 0.0587913 |
| LAMA5 | laminin, alpha 5 | 0.0573867 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0573865 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0561425 |
| TPM3 | tropomyosin 3 | 0.0560949 |
| MYOF | myoferlin | 0.0556181 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0554529 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0545475 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0504364 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0482669 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0464691 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.044582 |
| TXNIP | thioredoxin interacting protein | 0.043929 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0430219 |
| PGK1 | phosphoglycerate kinase 1 | 0.0429041 |
| CD44 | CD44 molecule (Indian blood group) | 0.0418746 |
| EZR | ezrin | 0.0416459 |
| DOCK5 | dedicator of cytokinesis 5 | 0.039941 |
| ARRDC3 | arrestin domain containing 3 | 0.0367643 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0364449 |
| HLA-C | major histocompatibility complex, class I, C | 0.0361169 |
| DHFR | dihydrofolate reductase | 0.0349438 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0346196 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0344542 |
| PTK2 | protein tyrosine kinase 2 | 0.0340081 |
| SEPTIN9 | septin 9 | 0.0336276 |
| YBX3 | Y box binding protein 3 | 0.0332755 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0332519 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0331888 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0331883 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.0327658 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0326846 |
| CMIP | c-Maf inducing protein | 0.0325668 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0325586 |
| CEP250 | centrosomal protein 250kDa | 0.0322527 |
| OPTN | optineurin | 0.0318991 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0316909 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0316252 |
| AFAP1 | actin filament associated protein 1 | 0.0315622 |
| FOXO1 | forkhead box O1 | 0.0315368 |
| FOXP1 | forkhead box P1 | 0.0313848 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0313482 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0312927 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0310712 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0310076 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0305502 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0300337 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0299291 |
| ADAR | adenosine deaminase, RNA-specific | 0.0298965 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.0298962 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0295622 |
| SLK | STE20-like kinase | 0.0294067 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0287528 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0281339 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0281079 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0278212 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0277662 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0277504 |
| FLNB | filamin B, beta | 0.0273598 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0272583 |
| EPHA2 | EPH receptor A2 | 0.0271018 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0270729 |
| ANXA11 | annexin A11 | 0.0267744 |
| RNF145 | ring finger protein 145 | 0.0265493 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0261846 |
| MSN | moesin | 0.0258294 |
| ANO6 | anoctamin 6 | 0.0258101 |
| MT1X | metallothionein 1X | 0.0257766 |
| H1-0 | H1.0 linker histone | 0.0257694 |
| BARX2 | BARX homeobox 2 | 0.0256186 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0253685 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0250286 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0250159 |
| RNF19B | ring finger protein 19B | 0.0250105 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024971 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0247612 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0246285 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0245457 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0243123 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0243035 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0241523 |
| ZNF638 | zinc finger protein 638 | 0.0240313 |
| TMF1 | TATA element modulatory factor 1 | 0.0238666 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0238473 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0236481 |
| ANXA2 | annexin A2 | 0.0233101 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | 0.0232547 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0232074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.300102 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.177909 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.152389 |
| DPYD | dihydropyrimidine dehydrogenase | -0.14949 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101806 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0898075 |
| INTS6 | integrator complex subunit 6 | -0.0878759 |
| SULF1 | sulfatase 1 | -0.087066 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0861827 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0851883 |
| POTEF | POTE ankyrin domain family, member F | -0.0679571 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.062161 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0579555 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0576062 |
| LDHA | lactate dehydrogenase A | -0.0572582 |
| RPS24 | ribosomal protein S24 | -0.0563891 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0554085 |
| S100A10 | S100 calcium binding protein A10 | -0.0535446 |
| PTMA | prothymosin, alpha | -0.053504 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0533774 |
| HMGA2 | high mobility group AT-hook 2 | -0.0532548 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0523132 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0522489 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0511033 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0506346 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0502615 |
| RPS13 | ribosomal protein S13 | -0.0485454 |
| RPS21 | ribosomal protein S21 | -0.0477445 |
| STC1 | stanniocalcin 1 | -0.0476757 |
| HM13 | histocompatibility (minor) 13 | -0.0461998 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0461808 |
| RPS3 | ribosomal protein S3 | -0.0460171 |
| RPLP2 | ribosomal protein, large, P2 | -0.0449662 |
| S100A2 | S100 calcium binding protein A2 | -0.0444489 |
| RASAL2 | RAS protein activator like 2 | -0.0443069 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0439785 |
| RPS8 | ribosomal protein S8 | -0.0438302 |
| RPL11 | ribosomal protein L11 | -0.0432222 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0431535 |
| RPS25 | ribosomal protein S25 | -0.0420934 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0419544 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0416569 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0415316 |
| GNAS | GNAS complex locus | -0.0411894 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0405203 |
| RPS23 | ribosomal protein S23 | -0.0397555 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0396924 |
| AHNAK | AHNAK nucleoprotein | -0.0393787 |
| RPL34 | ribosomal protein L34 | -0.0387927 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0382517 |
| C4BPB | complement component 4 binding protein, beta | -0.0381707 |
| PRSS23 | protease, serine, 23 | -0.0378358 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0377568 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0373376 |
| DIAPH3 | diaphanous-related formin 3 | -0.0370783 |
| NDRG1 | N-myc downstream regulated 1 | -0.0366287 |
| RPL37A | ribosomal protein L37a | -0.0354282 |
| S100A11 | S100 calcium binding protein A11 | -0.0345675 |
| ENO1 | enolase 1, (alpha) | -0.0340574 |
| THBD | thrombomodulin | -0.0333112 |
| RAD51B | RAD51 paralog B | -0.0332455 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0327534 |
| CRACDL | CRACD like | -0.0327155 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0322224 |
| RPS29 | ribosomal protein S29 | -0.0320059 |
| FTL | ferritin, light polypeptide | -0.0317937 |
| CDK6 | cyclin-dependent kinase 6 | -0.0313885 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.031372 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0312999 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0312059 |
| LAMC2 | laminin, gamma 2 | -0.0305661 |
| RPLP1 | ribosomal protein, large, P1 | -0.030507 |
| RPL19 | ribosomal protein L19 | -0.0300158 |
| ANLN | anillin, actin binding protein | -0.0294582 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.0294465 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0294409 |
| FRMD4B | FERM domain containing 4B | -0.0288262 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0286621 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0283475 |
| RPL31 | ribosomal protein L31 | -0.0281903 |
| RPL35A | ribosomal protein L35a | -0.0279192 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0278988 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0273142 |
| TMSB10 | thymosin beta 10 | -0.0272039 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0266786 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.026608 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0264625 |
| MTAP | methylthioadenosine phosphorylase | -0.0260655 |
| RCOR1 | REST corepressor 1 | -0.0260523 |
| UTRN | utrophin | -0.0259538 |
| MYO10 | myosin X | -0.0257456 |
| ARF1 | ADP-ribosylation factor 1 | -0.0254729 |
| RUNX1 | runt-related transcription factor 1 | -0.0254206 |
| SMYD3 | SET and MYND domain containing 3 | -0.0253606 |
| MORF4L2 | mortality factor 4 like 2 | -0.0252212 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0251098 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.02496 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0242492 |
| RPS19 | ribosomal protein S19 | -0.0241734 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0239539 |
