| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.128479 |
| HSPA8 | heat shock 70kDa protein 8 | 0.123462 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0927893 |
| ACTG1 | actin gamma 1 | 0.0873072 |
| EZR | ezrin | 0.0804048 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0704184 |
| LMO7 | LIM domain 7 | 0.069047 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0614174 |
| KRT8 | keratin 8, type II | 0.0577393 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0554579 |
| NEBL | nebulette | 0.0538298 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0505447 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0505352 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0500159 |
| MUC13 | mucin 13, cell surface associated | 0.0480063 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.047676 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0470291 |
| TPM3 | tropomyosin 3 | 0.0462119 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.043663 |
| MT2A | metallothionein 2A | 0.042926 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0426813 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0412585 |
| FAM13A | family with sequence similarity 13, member A | 0.0411886 |
| GOLGA4 | golgin A4 | 0.0401966 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0400542 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0383515 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0381938 |
| GOLGB1 | golgin B1 | 0.0381812 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0378186 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0376012 |
| LAMC2 | laminin, gamma 2 | 0.0362833 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0360277 |
| DHFR | dihydrofolate reductase | 0.0343498 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0335301 |
| RPS12 | ribosomal protein S12 | 0.0332787 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0324174 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0320619 |
| PGK1 | phosphoglycerate kinase 1 | 0.0318595 |
| ABHD2 | abhydrolase domain containing 2 | 0.0318408 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0314293 |
| MLF1 | myeloid leukemia factor 1 | 0.0309044 |
| ATF3 | activating transcription factor 3 | 0.0308563 |
| TMSB4X | thymosin beta 4, X-linked | 0.0306816 |
| WHRN | whirlin | 0.0306501 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0302683 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0295424 |
| SBF2 | SET binding factor 2 | 0.0292263 |
| EMP1 | epithelial membrane protein 1 | 0.028989 |
| CRY1 | cryptochrome circadian clock 1 | 0.0289219 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0288598 |
| ANXA1 | annexin A1 | 0.0287137 |
| VEGFA | vascular endothelial growth factor A | 0.0286728 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0283971 |
| FBXO32 | F-box protein 32 | 0.0280639 |
| HDLBP | high density lipoprotein binding protein | 0.027595 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0273475 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0270324 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0264328 |
| JUN | jun proto-oncogene | 0.0262853 |
| PER2 | period circadian clock 2 | 0.0259785 |
| HLA-A | major histocompatibility complex, class I, A | 0.0258988 |
| MT1X | metallothionein 1X | 0.0250795 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0250217 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.024628 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0245415 |
| TXNIP | thioredoxin interacting protein | 0.0243252 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0240801 |
| AFDN | afadin, adherens junction formation factor | 0.0239018 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0237407 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0236205 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0236018 |
| SVIL | supervillin | 0.0234933 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0234598 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0233806 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0233576 |
| PATJ | PATJ crumbs cell polarity complex component | 0.023225 |
| SIK3 | SIK family kinase 3 | 0.0229381 |
| DNM2 | dynamin 2 | 0.0227804 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0224932 |
| RORA | RAR-related orphan receptor A | 0.0223405 |
| RPL13A | ribosomal protein L13a | 0.0222066 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0220399 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0219548 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0216931 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0216144 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.021585 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0215668 |
| ATXN1 | ataxin 1 | 0.0213582 |
| MYO5B | myosin VB | 0.0209902 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0206721 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0205754 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.020553 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0205402 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0204387 |
| MXD1 | MAX dimerization protein 1 | 0.0202803 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0202757 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0201541 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0199097 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.019867 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0194012 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.2071 |
| PTMA | prothymosin, alpha | -0.185361 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.119981 |
| NPSR1 | neuropeptide S receptor 1 | -0.108664 |
| VCL | vinculin | -0.0907327 |
| RPLP1 | ribosomal protein, large, P1 | -0.0906954 |
| TMSB10 | thymosin beta 10 | -0.0872024 |
| TNS4 | tensin 4 | -0.0807144 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.071617 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0704756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0656267 |
| RAB10 | RAB10, member RAS oncogene family | -0.0654512 |
| S100A6 | S100 calcium binding protein A6 | -0.0616209 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.058678 |
| GPHN | gephyrin | -0.05727 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0550099 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.053951 |
| RPL23 | ribosomal protein L23 | -0.0523609 |
| HMGB1 | high mobility group box 1 | -0.0505943 |
| ACTN4 | actinin, alpha 4 | -0.0504967 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0498771 |
| RPL5 | ribosomal protein L5 | -0.0490398 |
| ANXA2 | annexin A2 | -0.0485497 |
| PKM | pyruvate kinase, muscle | -0.0473748 |
| RPS19 | ribosomal protein S19 | -0.0459352 |
| CCND1 | cyclin D1 | -0.0457104 |
| RNF43 | ring finger protein 43 | -0.0445908 |
| HMGA1 | high mobility group AT-hook 1 | -0.0423849 |
| RPL34 | ribosomal protein L34 | -0.0419731 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0418567 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0416841 |
| ITGA6 | integrin, alpha 6 | -0.0404348 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0402674 |
| RPL35A | ribosomal protein L35a | -0.03989 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0398643 |
| ASPH | aspartate beta-hydroxylase | -0.0395602 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0391108 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0384685 |
| RPS24 | ribosomal protein S24 | -0.0381892 |
| POTEF | POTE ankyrin domain family, member F | -0.0371268 |
| CD44 | CD44 molecule (Indian blood group) | -0.0370436 |
| TPM1 | tropomyosin 1 (alpha) | -0.0365579 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.036111 |
| FERMT1 | fermitin family member 1 | -0.0356258 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0350836 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0350268 |
| RBM39 | RNA binding motif protein 39 | -0.0350079 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0346214 |
| GNAS | GNAS complex locus | -0.0345502 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0343276 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0342757 |
| KRT19 | keratin 19, type I | -0.0336788 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0336522 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0333939 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0327643 |
| RPLP2 | ribosomal protein, large, P2 | -0.0325425 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.032517 |
| FHIT | fragile histidine triad | -0.0322756 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0322285 |
| ATF4 | activating transcription factor 4 | -0.0321676 |
| EGR1 | early growth response 1 | -0.0319013 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0318656 |
| MTAP | methylthioadenosine phosphorylase | -0.0318562 |
| INSIG1 | insulin induced gene 1 | -0.0318093 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0317349 |
| TOP1 | topoisomerase (DNA) I | -0.0315772 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0311017 |
| S100P | S100 calcium binding protein P | -0.0305621 |
| PALLD | palladin, cytoskeletal associated protein | -0.0304494 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0303131 |
| ONECUT3 | one cut homeobox 3 | -0.0300091 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0299125 |
| FOSL1 | FOS-like antigen 1 | -0.0294112 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0293688 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0292462 |
| SLC38A2 | solute carrier family 38, member 2 | -0.028952 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.028857 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0286062 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0285216 |
| LAMA4 | laminin, alpha 4 | -0.028505 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0284331 |
| RPL12 | ribosomal protein L12 | -0.0280296 |
| RPL36 | ribosomal protein L36 | -0.0279907 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0279503 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0279395 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0275269 |
| IER3 | immediate early response 3 | -0.0272096 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0271907 |
| PFN1 | profilin 1 | -0.0270016 |
| NRXN3 | neurexin 3 | -0.0266628 |
| ABLIM1 | actin binding LIM protein 1 | -0.0266446 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0265547 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0265325 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0260095 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0254991 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0254201 |
| HDAC2 | histone deacetylase 2 | -0.0254063 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0253108 |
| PTEN | phosphatase and tensin homolog | -0.0252448 |
| PCBP2 | poly(rC) binding protein 2 | -0.0252366 |
