| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.15191 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.104592 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.103877 |
| EZR | ezrin | 0.0965811 |
| RUNX1 | runt-related transcription factor 1 | 0.0896302 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0849931 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0827563 |
| MT1E | metallothionein 1E | 0.0749578 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0745062 |
| HLA-B | major histocompatibility complex, class I, B | 0.0740663 |
| TXNRD1 | thioredoxin reductase 1 | 0.0734093 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0698291 |
| ANGPTL4 | angiopoietin-like 4 | 0.0679756 |
| ACTG1 | actin gamma 1 | 0.0660875 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0655281 |
| RPS12 | ribosomal protein S12 | 0.0622765 |
| EREG | epiregulin | 0.0611439 |
| PODXL | podocalyxin-like | 0.0593082 |
| PGK1 | phosphoglycerate kinase 1 | 0.0580945 |
| TMSB4X | thymosin beta 4, X-linked | 0.0573809 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0554195 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0544513 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0540201 |
| JUN | jun proto-oncogene | 0.0520276 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0497167 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0483125 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0479408 |
| RPL12 | ribosomal protein L12 | 0.0453376 |
| RPS6 | ribosomal protein S6 | 0.0450575 |
| TXNIP | thioredoxin interacting protein | 0.0420883 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0419423 |
| ENO1 | enolase 1, (alpha) | 0.0412349 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0409146 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0400448 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0397658 |
| NDRG1 | N-myc downstream regulated 1 | 0.0397071 |
| SQSTM1 | sequestosome 1 | 0.0396033 |
| EMP1 | epithelial membrane protein 1 | 0.0374551 |
| UBC | ubiquitin C | 0.0371204 |
| RPL26 | ribosomal protein L26 | 0.036638 |
| YEATS2 | YEATS domain containing 2 | 0.0366142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0358268 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0357421 |
| KRT18 | keratin 18, type I | 0.035061 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0338496 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0335407 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.033505 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0333675 |
| CEP250 | centrosomal protein 250kDa | 0.0330481 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0328772 |
| ARFGEF3 | ARFGEF family member 3 | 0.0325907 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.03217 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0320558 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0316925 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0315072 |
| CAPRIN2 | caprin family member 2 | 0.0304112 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0303577 |
| RPL4 | ribosomal protein L4 | 0.0300757 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0290958 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0288408 |
| RPL37 | ribosomal protein L37 | 0.0284856 |
| YBX3 | Y box binding protein 3 | 0.0276936 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0275444 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0271637 |
| MT1X | metallothionein 1X | 0.0270787 |
| RPL39 | ribosomal protein L39 | 0.0270646 |
| SEC24A | SEC24 family member A | 0.0270323 |
| RPL19 | ribosomal protein L19 | 0.0268647 |
| NPAS2 | neuronal PAS domain protein 2 | 0.026779 |
| SLK | STE20-like kinase | 0.0263983 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.026375 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0259146 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0257425 |
| RPS17 | ribosomal protein S17 | 0.0256722 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0252042 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0250963 |
| ADM | adrenomedullin | 0.0249456 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0249292 |
| AHNAK | AHNAK nucleoprotein | 0.0245765 |
| TMF1 | TATA element modulatory factor 1 | 0.0245205 |
| FBXO17 | F-box protein 17 | 0.0245067 |
| PLEC | plectin | 0.0244936 |
| FOSL1 | FOS-like antigen 1 | 0.024396 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0243346 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0239519 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0237789 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0235247 |
| HMGA1 | high mobility group AT-hook 1 | 0.023308 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0232659 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | 0.0231353 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0229729 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0227175 |
| ARRDC3 | arrestin domain containing 3 | 0.0226771 |
| PLIN2 | perilipin 2 | 0.0225552 |
| RPS10 | ribosomal protein S10 | 0.0223591 |
| RPS8 | ribosomal protein S8 | 0.0222801 |
| SNX9 | sorting nexin 9 | 0.0222496 |
| RPL27 | ribosomal protein L27 | 0.0222434 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0222394 |
| RPS20 | ribosomal protein S20 | 0.0220532 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.133357 |
| PTMA | prothymosin, alpha | -0.127039 |
| TP63 | tumor protein p63 | -0.0852743 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0781942 |
| VIM | vimentin | -0.0754963 |
| TMSB10 | thymosin beta 10 | -0.0749774 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0722898 |
| POTEF | POTE ankyrin domain family, member F | -0.0656806 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.057389 |
| EHBP1 | EH domain binding protein 1 | -0.0539664 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0533251 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0533169 |
| EFNA5 | ephrin-A5 | -0.049841 |
| TNS3 | tensin 3 | -0.0462374 |
| CADM2 | cell adhesion molecule 2 | -0.0454457 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0437505 |
| RCOR1 | REST corepressor 1 | -0.0400657 |
| GNAS | GNAS complex locus | -0.0399605 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0389865 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0386328 |
| VCL | vinculin | -0.0381638 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0366376 |
| MT2A | metallothionein 2A | -0.0362116 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0357984 |
| CENPF | centromere protein F, 350/400kDa | -0.0356671 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0354468 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0346356 |
| FNIP1 | folliculin interacting protein 1 | -0.034372 |
| INTS6 | integrator complex subunit 6 | -0.0337791 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0322 |
| SP100 | SP100 nuclear antigen | -0.0319891 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0317234 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0317228 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0317188 |
| EPHA4 | EPH receptor A4 | -0.0315112 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0313728 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0307405 |
| CMIP | c-Maf inducing protein | -0.030206 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0297564 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0297294 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0296888 |
| STK17A | serine/threonine kinase 17a | -0.0286205 |
| ZNF207 | zinc finger protein 207 | -0.0286189 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0281762 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0280253 |
| COL5A2 | collagen, type V, alpha 2 | -0.0280051 |
| RBM39 | RNA binding motif protein 39 | -0.0269949 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0266783 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0266385 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0265513 |
| CD44 | CD44 molecule (Indian blood group) | -0.0265347 |
| APP | amyloid beta (A4) precursor protein | -0.0265309 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0263485 |
| AEBP2 | AE binding protein 2 | -0.0263256 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0263233 |
| TGM2 | transglutaminase 2 | -0.0263023 |
| EXOC4 | exocyst complex component 4 | -0.0258857 |
| TSC22D2 | TSC22 domain family, member 2 | -0.025424 |
| RBM25 | RNA binding motif protein 25 | -0.0253898 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0245953 |
| PTK2 | protein tyrosine kinase 2 | -0.0244524 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0243287 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.02416 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0239282 |
| ECT2 | epithelial cell transforming 2 | -0.0238416 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.023721 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0236168 |
| MKI67 | marker of proliferation Ki-67 | -0.0235396 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0234552 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0233783 |
| TOP1 | topoisomerase (DNA) I | -0.0230358 |
| MB21D2 | Mab-21 domain containing 2 | -0.0228955 |
| NEK10 | NIMA-related kinase 10 | -0.0227278 |
| NPR2 | natriuretic peptide receptor 2 | -0.0224485 |
| DIAPH3 | diaphanous-related formin 3 | -0.0222841 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0222649 |
| UBAP2 | ubiquitin associated protein 2 | -0.0221609 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0217481 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0217288 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0215955 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0214028 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0214006 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0213532 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0212835 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0212588 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0211553 |
| ZNF217 | zinc finger protein 217 | -0.0210516 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0210022 |
| HDAC9 | histone deacetylase 9 | -0.020747 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0204842 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.020451 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0203677 |
| ZNF609 | zinc finger protein 609 | -0.0203012 |
| NUP98 | nucleoporin 98kDa | -0.0201096 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0201079 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0198902 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0196497 |
| TAOK1 | TAO kinase 1 | -0.0195749 |
| DNER | delta/notch-like EGF repeat containing | -0.0193835 |
| STAG2 | stromal antigen 2 | -0.0193584 |
