| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.297274 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.261084 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.145822 |
| SMAD3 | SMAD family member 3 | 0.126967 |
| LOC112694756 | uncharaterized LOC112694756 | 0.112237 |
| FAM13A | family with sequence similarity 13, member A | 0.0974849 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0934593 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0929635 |
| GRAMD1B | GRAM domain containing 1B | 0.0922817 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0795248 |
| EGR1 | early growth response 1 | 0.0761676 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0717368 |
| KRT18 | keratin 18, type I | 0.0681634 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0607408 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0569829 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0569348 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0561716 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0547289 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0546987 |
| SLTM | SAFB-like, transcription modulator | 0.0526491 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0505398 |
| STC1 | stanniocalcin 1 | 0.0504126 |
| PGK1 | phosphoglycerate kinase 1 | 0.0492553 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0484624 |
| PLEC | plectin | 0.0484543 |
| RNF213 | ring finger protein 213 | 0.0476151 |
| MT2A | metallothionein 2A | 0.0464914 |
| TPM3 | tropomyosin 3 | 0.0458013 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0444092 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0443708 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0429635 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0429104 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0426026 |
| ACTG1 | actin gamma 1 | 0.0424834 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0421585 |
| MCL1 | myeloid cell leukemia 1 | 0.0407529 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0406148 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0402922 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0395575 |
| HLA-B | major histocompatibility complex, class I, B | 0.0394888 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.039242 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0370119 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.036332 |
| JUN | jun proto-oncogene | 0.0357837 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0351514 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0350619 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0350126 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0338769 |
| EMP1 | epithelial membrane protein 1 | 0.0334477 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0334366 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0332176 |
| DHFR | dihydrofolate reductase | 0.0329638 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0326653 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0325789 |
| ARRDC3 | arrestin domain containing 3 | 0.0323166 |
| SMYD3 | SET and MYND domain containing 3 | 0.0322387 |
| RAD51B | RAD51 paralog B | 0.0310945 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0307425 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0300085 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0296118 |
| MLF1 | myeloid leukemia factor 1 | 0.0286637 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0283532 |
| CES1 | carboxylesterase 1 | 0.0283373 |
| MAGEA4 | melanoma antigen family A4 | 0.0282444 |
| DIAPH1 | diaphanous-related formin 1 | 0.0281156 |
| ATF3 | activating transcription factor 3 | 0.0278546 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0278208 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0276264 |
| RPL37A | ribosomal protein L37a | 0.02758 |
| RPS3 | ribosomal protein S3 | 0.0270656 |
| ZNF292 | zinc finger protein 292 | 0.0270341 |
| RPS6 | ribosomal protein S6 | 0.0268159 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0267109 |
| HLA-A | major histocompatibility complex, class I, A | 0.0266273 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0263145 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0262819 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0262165 |
| PER2 | period circadian clock 2 | 0.026078 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0260262 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0259713 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0259682 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0259015 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0257171 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.025223 |
| TMEM45B | transmembrane protein 45B | 0.0251504 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0245996 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0241565 |
| B2M | beta-2-microglobulin | 0.0241032 |
| CUL4A | cullin 4A | 0.024083 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0238341 |
| SON | SON DNA binding protein | 0.0235504 |
| FAM107B | family with sequence similarity 107, member B | 0.0234183 |
| ENO1 | enolase 1, (alpha) | 0.0231736 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0230117 |
| IRF1 | interferon regulatory factor 1 | 0.0229831 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0229384 |
| RPL37 | ribosomal protein L37 | 0.0225439 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0225348 |
| EZR | ezrin | 0.0224463 |
| GOLGA4 | golgin A4 | 0.0224021 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.206052 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.135106 |
| ASPH | aspartate beta-hydroxylase | -0.120481 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0885878 |
| OSMR | oncostatin M receptor | -0.0736863 |
| MKI67 | marker of proliferation Ki-67 | -0.0653457 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.061738 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0603651 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0499591 |
| VCL | vinculin | -0.047661 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0473061 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.043492 |
| TOP1 | topoisomerase (DNA) I | -0.041751 |
| USP34 | ubiquitin specific peptidase 34 | -0.0416524 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0405091 |
| CCND1 | cyclin D1 | -0.0398125 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0377517 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0371845 |
| TES | testin LIM domain protein | -0.0370601 |
| LDHA | lactate dehydrogenase A | -0.0366617 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0362905 |
| SCEL | sciellin | -0.0359496 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0356248 |
| USP53 | ubiquitin specific peptidase 53 | -0.0346867 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0333849 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0333554 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0331378 |
| PAPOLA | poly(A) polymerase alpha | -0.0327824 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0324103 |
| TMSB10 | thymosin beta 10 | -0.0322328 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0320553 |
| RAB10 | RAB10, member RAS oncogene family | -0.0320214 |
| SPAG9 | sperm associated antigen 9 | -0.03147 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0312964 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0312647 |
| FRMD4B | FERM domain containing 4B | -0.031167 |
| CST3 | cystatin C | -0.0304545 |
| CLTC | clathrin, heavy chain (Hc) | -0.0298026 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0297929 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0297192 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0295797 |
| NABP1 | nucleic acid binding protein 1 | -0.0291938 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0285824 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0278079 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0276037 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0275845 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0275786 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0269123 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0267339 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0267337 |
| NF1 | neurofibromin 1 | -0.0263978 |
| PKM | pyruvate kinase, muscle | -0.0258057 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0254377 |
| RPS24 | ribosomal protein S24 | -0.0248108 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0245129 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0243614 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0242251 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0240507 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0238492 |
| ABLIM1 | actin binding LIM protein 1 | -0.0236223 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0231242 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0228292 |
| MORF4L2 | mortality factor 4 like 2 | -0.022633 |
| ZNF217 | zinc finger protein 217 | -0.0225886 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0218961 |
| RBM39 | RNA binding motif protein 39 | -0.0218547 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0215172 |
| OXSR1 | oxidative stress responsive 1 | -0.0215019 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0213695 |
| GNAS | GNAS complex locus | -0.021311 |
| PERP | PERP, TP53 apoptosis effector | -0.021144 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0210057 |
| RASA2 | RAS p21 protein activator 2 | -0.0208493 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0207429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0206187 |
| WDR45B | WD repeat domain 45B | -0.0204134 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.020411 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0204108 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0204095 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0202173 |
| WASF2 | WAS protein family, member 2 | -0.0201041 |
| RCOR1 | REST corepressor 1 | -0.0200976 |
| FBXO11 | F-box protein 11 | -0.0199361 |
| LMO7 | LIM domain 7 | -0.0198808 |
| AEBP2 | AE binding protein 2 | -0.0198514 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0195916 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0195287 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0193506 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0193157 |
| TKT | transketolase | -0.0191498 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0183671 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0183092 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0182682 |
| INTS6 | integrator complex subunit 6 | -0.0181927 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0181786 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0180357 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0180175 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0179289 |
| ZNF207 | zinc finger protein 207 | -0.0178326 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.01771 |
