| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.180206 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.126507 |
| CD44 | CD44 molecule (Indian blood group) | 0.113217 |
| SMAD3 | SMAD family member 3 | 0.107708 |
| FNDC3B | fibronectin type III domain containing 3B | 0.103036 |
| GRB10 | growth factor receptor-bound protein 10 | 0.100398 |
| NAV2 | neuron navigator 2 | 0.0964919 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0813683 |
| VEGFA | vascular endothelial growth factor A | 0.0689209 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.067356 |
| TGM2 | transglutaminase 2 | 0.0647173 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0583904 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0558417 |
| LOXL2 | lysyl oxidase-like 2 | 0.0545449 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0521354 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0488002 |
| ADM | adrenomedullin | 0.0483929 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0481254 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0475583 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.047484 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0473943 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0467979 |
| FAM107B | family with sequence similarity 107, member B | 0.0465945 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0426522 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0425895 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0397829 |
| CA12 | carbonic anhydrase XII | 0.0397715 |
| EZR | ezrin | 0.0396224 |
| FAM13A | family with sequence similarity 13, member A | 0.0393833 |
| PFKP | phosphofructokinase, platelet | 0.0383298 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0377086 |
| IL1R1 | interleukin 1 receptor, type I | 0.0372825 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.036678 |
| ZNF638 | zinc finger protein 638 | 0.0358819 |
| CEP250 | centrosomal protein 250kDa | 0.0358664 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0358109 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0355684 |
| EGR1 | early growth response 1 | 0.0354025 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0352269 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0351978 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0351692 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0350839 |
| EFNA5 | ephrin-A5 | 0.0349067 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0347288 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0341314 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0334896 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0333861 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0331543 |
| ECE1 | endothelin converting enzyme 1 | 0.0330808 |
| NDRG1 | N-myc downstream regulated 1 | 0.0326138 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0322833 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0315808 |
| JUN | jun proto-oncogene | 0.0315645 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0309672 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0305284 |
| DHFR | dihydrofolate reductase | 0.0303427 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0291742 |
| HAS2 | hyaluronan synthase 2 | 0.0286786 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0281466 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0279529 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.027866 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0276942 |
| SEPTIN9 | septin 9 | 0.0274678 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0271765 |
| PLEC | plectin | 0.0271656 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0270968 |
| OPTN | optineurin | 0.0270953 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0270443 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0268787 |
| FAM219A | family with sequence similarity 219, member A | 0.0267477 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0267041 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0263892 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0259367 |
| RAD51B | RAD51 paralog B | 0.0258662 |
| STK38L | serine/threonine kinase 38 like | 0.0256182 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0255824 |
| ATXN1 | ataxin 1 | 0.0254401 |
| HDAC9 | histone deacetylase 9 | 0.0244166 |
| CRY1 | cryptochrome circadian clock 1 | 0.0243714 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.0242275 |
| ZNF469 | zinc finger protein 469 | 0.0239718 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0239306 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0237548 |
| TNS1 | tensin 1 | 0.0233009 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.023151 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0231144 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0228967 |
| TNNC1 | troponin C type 1 (slow) | 0.0227985 |
| BRD2 | bromodomain containing 2 | 0.0227099 |
| MAP1B | microtubule-associated protein 1B | 0.0225393 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0225283 |
| RUNX1 | runt-related transcription factor 1 | 0.0225052 |
| VMP1 | vacuole membrane protein 1 | 0.0222289 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0221189 |
| SIK3 | SIK family kinase 3 | 0.0220397 |
| NOTCH2 | notch 2 | 0.0219345 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0218459 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0213823 |
| HLA-B | major histocompatibility complex, class I, B | 0.0211805 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | 0.0209424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.209957 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.172685 |
| VIM | vimentin | -0.147088 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.126955 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.115178 |
| PTMA | prothymosin, alpha | -0.111937 |
| RBM39 | RNA binding motif protein 39 | -0.0921693 |
| USP34 | ubiquitin specific peptidase 34 | -0.0869469 |
| TMSB10 | thymosin beta 10 | -0.0843465 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0812601 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0752439 |
| FN1 | fibronectin 1 | -0.0707635 |
| MTSS1 | metastasis suppressor 1 | -0.0687862 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.067511 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0663601 |
| GLCCI1 | glucocorticoid induced 1 | -0.0634828 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0624249 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0618681 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0608035 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.05955 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0593745 |
| NRG1 | neuregulin 1 | -0.0579067 |
| RPLP1 | ribosomal protein, large, P1 | -0.0557679 |
| HMGA2 | high mobility group AT-hook 2 | -0.0556304 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0552854 |
| GNAS | GNAS complex locus | -0.0546775 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0542802 |
| LOX | lysyl oxidase | -0.0542282 |
| IER3 | immediate early response 3 | -0.0532365 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0527742 |
| CDH13 | cadherin 13 | -0.0495674 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0483137 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0481485 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0478616 |
| MECOM | MDS1 and EVI1 complex locus | -0.0473954 |
| TMEM131 | transmembrane protein 131 | -0.0472652 |
| RIOK3 | RIO kinase 3 | -0.0471717 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0471299 |
| ETV6 | ets variant 6 | -0.0470486 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0459393 |
| CANX | calnexin | -0.0459222 |
| FTL | ferritin, light polypeptide | -0.0456464 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0437124 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0426655 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0425248 |
| NUMB | numb homolog (Drosophila) | -0.0423651 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.042102 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0414543 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0413306 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0408304 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0405277 |
| STC1 | stanniocalcin 1 | -0.0405194 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0405035 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0402599 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0399465 |
| RPS24 | ribosomal protein S24 | -0.0398781 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0397532 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0394418 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0392405 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0385987 |
| SEPTIN7 | septin 7 | -0.0383121 |
| OXSR1 | oxidative stress responsive 1 | -0.0378265 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0376802 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0374559 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0372174 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0365068 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0364059 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0363921 |
| FDPS | farnesyl diphosphate synthase | -0.0361604 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0360403 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.035664 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0350986 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0347762 |
| DNER | delta/notch-like EGF repeat containing | -0.034555 |
| ANXA10 | annexin A10 | -0.0344447 |
| OSMR | oncostatin M receptor | -0.0343302 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0340234 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0337741 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0337403 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0337321 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0336056 |
| S100A6 | S100 calcium binding protein A6 | -0.033573 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0334374 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0333218 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0328323 |
| WDR45B | WD repeat domain 45B | -0.0325932 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0322439 |
| EREG | epiregulin | -0.0316436 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0315581 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0312244 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0312135 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0311834 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0311789 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0308598 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0306214 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0305962 |
| NAV3 | neuron navigator 3 | -0.0304719 |
| CCDC88A | coiled-coil domain containing 88A | -0.0304628 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0303079 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.030168 |
