| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.138164 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.116491 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0925948 |
| HLA-B | major histocompatibility complex, class I, B | 0.0862226 |
| ACTG1 | actin gamma 1 | 0.0753054 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.072251 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.054103 |
| UBC | ubiquitin C | 0.0520215 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0475441 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0473155 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0434187 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0430652 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0421989 |
| FTL | ferritin, light polypeptide | 0.0421781 |
| HLA-A | major histocompatibility complex, class I, A | 0.0420714 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0403065 |
| BRD2 | bromodomain containing 2 | 0.0396664 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0390252 |
| B2M | beta-2-microglobulin | 0.0369572 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0362245 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0358389 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0356405 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352722 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0346958 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0344314 |
| MCL1 | myeloid cell leukemia 1 | 0.0331966 |
| STC1 | stanniocalcin 1 | 0.0326162 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.032334 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0306383 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0306141 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.03045 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0304354 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0303012 |
| MT1X | metallothionein 1X | 0.0301218 |
| COPA | coatomer protein complex, subunit alpha | 0.0298663 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0296547 |
| TPM3 | tropomyosin 3 | 0.0296503 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0287608 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0276035 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0269724 |
| RPS8 | ribosomal protein S8 | 0.0268033 |
| HLA-E | major histocompatibility complex, class I, E | 0.026518 |
| RPL37A | ribosomal protein L37a | 0.0264564 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0258867 |
| RPS27A | ribosomal protein S27a | 0.0257759 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0257483 |
| NEK7 | NIMA-related kinase 7 | 0.0256158 |
| ADM | adrenomedullin | 0.0255772 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0254114 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0250955 |
| RPS12 | ribosomal protein S12 | 0.0250321 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.024607 |
| HLA-C | major histocompatibility complex, class I, C | 0.0243238 |
| FMNL2 | formin-like 2 | 0.0240815 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0240298 |
| CALR | calreticulin | 0.0237592 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0232319 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0228368 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0226131 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0225837 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0223986 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0219821 |
| FLNB | filamin B, beta | 0.0218431 |
| RPS17 | ribosomal protein S17 | 0.021719 |
| MLF1 | myeloid leukemia factor 1 | 0.0214845 |
| NDRG1 | N-myc downstream regulated 1 | 0.0210357 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0209151 |
| RPL13A | ribosomal protein L13a | 0.0208118 |
| JUN | jun proto-oncogene | 0.0207323 |
| RPL31 | ribosomal protein L31 | 0.0207045 |
| RNF145 | ring finger protein 145 | 0.0205797 |
| RPL23 | ribosomal protein L23 | 0.0203855 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0203245 |
| RPS13 | ribosomal protein S13 | 0.0202877 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.020103 |
| GLG1 | golgi glycoprotein 1 | 0.0200464 |
| RPL37 | ribosomal protein L37 | 0.0196128 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0196017 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0192294 |
| PCBP2 | poly(rC) binding protein 2 | 0.0191724 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0191301 |
| KRT18 | keratin 18, type I | 0.0189672 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0187214 |
| EZR | ezrin | 0.0186637 |
| IL6 | interleukin 6 | 0.0185241 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0179658 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0179531 |
| EFNA1 | ephrin-A1 | 0.0179296 |
| SIK3 | SIK family kinase 3 | 0.0178214 |
| RPL15 | ribosomal protein L15 | 0.0177929 |
| RPLP1 | ribosomal protein, large, P1 | 0.017788 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0177683 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.017767 |
| MATR3 | matrin 3 | 0.0176496 |
| YTHDC1 | YTH domain containing 1 | 0.017624 |
| ANXA1 | annexin A1 | 0.0175886 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0175045 |
| USP36 | ubiquitin specific peptidase 36 | 0.0174191 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0173697 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.017155 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.142859 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0756569 |
| BICC1 | BicC family RNA binding protein 1 | -0.0722292 |
| TXNRD1 | thioredoxin reductase 1 | -0.0711617 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0663688 |
| GRAMD1B | GRAM domain containing 1B | -0.0651039 |
| VIM | vimentin | -0.0635418 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0634158 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0497542 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0470109 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0465515 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0463778 |
| DST | dystonin | -0.0439839 |
| EFNA5 | ephrin-A5 | -0.0422513 |
| HDAC9 | histone deacetylase 9 | -0.0420869 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0393593 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0383528 |
| CMIP | c-Maf inducing protein | -0.0380402 |
| USP34 | ubiquitin specific peptidase 34 | -0.0374961 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0371014 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0370471 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0367943 |
| ERBIN | erbb2 interacting protein | -0.0358566 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0357247 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0337785 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0335255 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0330485 |
| CAVIN1 | caveolae associated protein 1 | -0.0309483 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0307639 |
| IGF2 | insulin-like growth factor 2 | -0.0303131 |
| AK1 | adenylate kinase 1 | -0.0301084 |
| ASPH | aspartate beta-hydroxylase | -0.0297974 |
| MYOF | myoferlin | -0.0289364 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0287203 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0274218 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0274044 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0273863 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0273704 |
| ECT2 | epithelial cell transforming 2 | -0.0271392 |
| OSMR | oncostatin M receptor | -0.0270212 |
| LDHA | lactate dehydrogenase A | -0.0268767 |
| WWOX | WW domain containing oxidoreductase | -0.0268548 |
| ANXA2 | annexin A2 | -0.0267578 |
| GLIS3 | GLIS family zinc finger 3 | -0.0249424 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0248642 |
| NHSL1 | NHS-like 1 | -0.0246649 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0244613 |
| SVIL | supervillin | -0.0243093 |
| TMEM131 | transmembrane protein 131 | -0.0240697 |
| ZNF804A | zinc finger protein 804A | -0.0238221 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0237054 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0228417 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0225402 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.022448 |
| VCL | vinculin | -0.0224127 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.022392 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0223392 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0223068 |
| RTN4 | reticulon 4 | -0.0220221 |
| TMEM123 | transmembrane protein 123 | -0.0220106 |
| NTN4 | netrin 4 | -0.0219867 |
| NAV3 | neuron navigator 3 | -0.0218234 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0217053 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0212108 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0210828 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0210446 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0209327 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0208716 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0196438 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.019539 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0192329 |
| BMP5 | bone morphogenetic protein 5 | -0.0186688 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0185827 |
| PKM | pyruvate kinase, muscle | -0.0184526 |
| GNAS | GNAS complex locus | -0.0184029 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0183369 |
| LAMB1 | laminin, beta 1 | -0.0180597 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0177067 |
| CENPF | centromere protein F, 350/400kDa | -0.017627 |
| TPM4 | tropomyosin 4 | -0.0175857 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0175388 |
| IGF1R | insulin-like growth factor 1 receptor | -0.017524 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0175007 |
| MKI67 | marker of proliferation Ki-67 | -0.0173822 |
| NEGR1 | neuronal growth regulator 1 | -0.0173239 |
| SMAD2 | SMAD family member 2 | -0.0172327 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0172223 |
| UTRN | utrophin | -0.0171551 |
| PARK7 | parkinson protein 7 | -0.0171442 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0171311 |
| NEMF | nuclear export mediator factor | -0.0170144 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0168022 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0166511 |
| OLA1 | Obg-like ATPase 1 | -0.0165342 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0163632 |
| RPS21 | ribosomal protein S21 | -0.0163178 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0160785 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0160676 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0160442 |
| NCOA7 | nuclear receptor coactivator 7 | -0.015913 |
