| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.108678 |
| MYO1E | myosin IE | 0.108644 |
| FN1 | fibronectin 1 | 0.107489 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.104361 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0971997 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0809556 |
| NDRG1 | N-myc downstream regulated 1 | 0.0782008 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0771887 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0744085 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0734543 |
| SMYD3 | SET and MYND domain containing 3 | 0.072024 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.068681 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0657711 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0635462 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0627851 |
| MYOF | myoferlin | 0.0611706 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0593274 |
| EXOC4 | exocyst complex component 4 | 0.0590105 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.058109 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0574067 |
| JUN | jun proto-oncogene | 0.0573241 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0570291 |
| RAD51B | RAD51 paralog B | 0.0538512 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0537772 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0532821 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0527731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0520504 |
| FOXO3 | forkhead box O3 | 0.0518864 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0514515 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0511617 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0502168 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0498255 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0488373 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0485907 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0482535 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0457591 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0449047 |
| FLNB | filamin B, beta | 0.0448572 |
| CANX | calnexin | 0.0444174 |
| EHBP1 | EH domain binding protein 1 | 0.0441239 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0440562 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0438882 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0431302 |
| SLC16A13 | solute carrier family 16, member 13 | 0.0429909 |
| GRK6 | G protein-coupled receptor kinase 6 | 0.0427164 |
| PIPOX | pipecolic acid oxidase | 0.042667 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0425389 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0424203 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0408777 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0406552 |
| KRT8 | keratin 8, type II | 0.0402454 |
| FAM107B | family with sequence similarity 107, member B | 0.0402196 |
| TOP1 | topoisomerase (DNA) I | 0.0395348 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0395156 |
| COL5A2 | collagen, type V, alpha 2 | 0.0391915 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0384344 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0378834 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.037847 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.03784 |
| AGO2 | argonaute RISC catalytic component 2 | 0.03755 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0372599 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0369121 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0365926 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0363761 |
| RIGI | RNA sensor RIG-I | 0.0363222 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0360049 |
| NBEAL1 | neurobeachin-like 1 | 0.0359322 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0359143 |
| TUFT1 | tuftelin 1 | 0.0356611 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0354814 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0349925 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0345896 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0344277 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0342818 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0342505 |
| CDH13 | cadherin 13 | 0.0340685 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0340453 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0337252 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0334312 |
| ADM | adrenomedullin | 0.0334154 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.0331134 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0331086 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0329084 |
| ATXN1 | ataxin 1 | 0.0328851 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0328773 |
| ABHD17C | abhydrolase domain containing 17C | 0.0327975 |
| UBN2 | ubinuclein 2 | 0.0327666 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0326272 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.0326088 |
| CSNK1E | casein kinase 1, epsilon | 0.0325353 |
| DUSP10 | dual specificity phosphatase 10 | 0.0325263 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0324885 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0324195 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0320341 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0318785 |
| RTN4 | reticulon 4 | 0.0315037 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0311717 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0311242 |
| CD44 | CD44 molecule (Indian blood group) | 0.0310917 |
| AGO3 | argonaute RISC catalytic component 3 | 0.030945 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATOSA | atos homolog A | -0.156008 |
| LMO7 | LIM domain 7 | -0.146887 |
| TXNRD1 | thioredoxin reductase 1 | -0.095383 |
| EGFR | epidermal growth factor receptor | -0.0933302 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0902414 |
| MUC16 | mucin 16, cell surface associated | -0.0877326 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0819042 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0818505 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0764013 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0751809 |
| PARD3 | par-3 family cell polarity regulator | -0.0736518 |
| RBM47 | RNA binding motif protein 47 | -0.0724276 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0686679 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0681249 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0668289 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0591554 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0575369 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0557122 |
| ZNF207 | zinc finger protein 207 | -0.055198 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0550343 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0546522 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0546503 |
| MYO5C | myosin VC | -0.0544654 |
| TJP1 | tight junction protein 1 | -0.0541336 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0537706 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0519972 |
| ERBIN | erbb2 interacting protein | -0.0502357 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0495677 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.048622 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0474856 |
| DUSP16 | dual specificity phosphatase 16 | -0.0469797 |
| USP34 | ubiquitin specific peptidase 34 | -0.0468467 |
| TMEM165 | transmembrane protein 165 | -0.045576 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0455124 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0435015 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0434083 |
| RCOR1 | REST corepressor 1 | -0.0433847 |
| MED13 | mediator complex subunit 13 | -0.0432184 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0421891 |
| TGFA | transforming growth factor, alpha | -0.0418682 |
| HMGA2 | high mobility group AT-hook 2 | -0.0417873 |
| JMJD1C | jumonji domain containing 1C | -0.0416645 |
| UBAP1 | ubiquitin associated protein 1 | -0.0403902 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0403453 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0392011 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0388322 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0378166 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0375196 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0374626 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0369861 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0365856 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0365484 |
| OSMR | oncostatin M receptor | -0.0363861 |
| MCU | mitochondrial calcium uniporter | -0.0362282 |
| KLF6 | Kruppel-like factor 6 | -0.0361718 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0360822 |
| CLDN7 | claudin 7 | -0.035853 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.0357723 |
| ZNF292 | zinc finger protein 292 | -0.0354665 |
| MEF2A | myocyte enhancer factor 2A | -0.0352401 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0350119 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0346759 |
| PRKCA | protein kinase C, alpha | -0.0344548 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0337715 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0337477 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.033656 |
| GNAS | GNAS complex locus | -0.0334178 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0333936 |
| FAM13A | family with sequence similarity 13, member A | -0.0333537 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0331456 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0328851 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0328503 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0325093 |
| TXNIP | thioredoxin interacting protein | -0.0321366 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0321211 |
| KIF13B | kinesin family member 13B | -0.031978 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0319617 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0319182 |
| ITGB4 | integrin, beta 4 | -0.0318927 |
| SQSTM1 | sequestosome 1 | -0.0317684 |
| SPAG9 | sperm associated antigen 9 | -0.0317523 |
| ASPH | aspartate beta-hydroxylase | -0.0316991 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0308512 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0307279 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0304983 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0303877 |
| PLSCR1 | phospholipid scramblase 1 | -0.0303269 |
| CD2AP | CD2-associated protein | -0.0302473 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0302224 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.030208 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0301534 |
| SPPL3 | signal peptide peptidase like 3 | -0.0301511 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.029978 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0297162 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0295972 |
| TULP4 | tubby like protein 4 | -0.0295151 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0294245 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0293481 |
| RPS14 | ribosomal protein S14 | -0.0292319 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0291677 |
