| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.444623 |
| ACTG1 | actin gamma 1 | 0.0906495 |
| TPM3 | tropomyosin 3 | 0.0660402 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0653503 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0643123 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0608856 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0511391 |
| TPM2 | tropomyosin 2 (beta) | 0.0486954 |
| KRT18 | keratin 18, type I | 0.0482685 |
| HLA-B | major histocompatibility complex, class I, B | 0.0477349 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0462249 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0452396 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0437105 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0426488 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0419056 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0412072 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0393249 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0376601 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0373974 |
| VMP1 | vacuole membrane protein 1 | 0.0367868 |
| PGK1 | phosphoglycerate kinase 1 | 0.0359999 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0351149 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0350751 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0348387 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0347195 |
| MT2A | metallothionein 2A | 0.034484 |
| COPA | coatomer protein complex, subunit alpha | 0.0330343 |
| LOXL2 | lysyl oxidase-like 2 | 0.0329413 |
| JUN | jun proto-oncogene | 0.0319864 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0312387 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0307808 |
| INTS3 | integrator complex subunit 3 | 0.0306532 |
| TCIM | transcriptional and immune response regulator | 0.0305057 |
| PRKCE | protein kinase C, epsilon | 0.0298382 |
| FMNL2 | formin-like 2 | 0.029527 |
| EGR1 | early growth response 1 | 0.0293412 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0291798 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0280503 |
| GRAMD1B | GRAM domain containing 1B | 0.0277604 |
| ICAM1 | intercellular adhesion molecule 1 | 0.027677 |
| HLA-A | major histocompatibility complex, class I, A | 0.0269421 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.026488 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0264603 |
| EGFR | epidermal growth factor receptor | 0.0263782 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0261372 |
| SMAD3 | SMAD family member 3 | 0.0257722 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0251953 |
| MCL1 | myeloid cell leukemia 1 | 0.0250903 |
| PRELID3B | PRELI domain containing 3B | 0.0244218 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0243327 |
| B2M | beta-2-microglobulin | 0.0243289 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0239185 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0237003 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0234319 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0230319 |
| WWOX | WW domain containing oxidoreductase | 0.0229361 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0227255 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0226277 |
| FAM13A | family with sequence similarity 13, member A | 0.0223341 |
| PLEC | plectin | 0.0222909 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0220517 |
| NCOR2 | nuclear receptor corepressor 2 | 0.022004 |
| RPL37A | ribosomal protein L37a | 0.0219003 |
| CEP250 | centrosomal protein 250kDa | 0.0218271 |
| CRY1 | cryptochrome circadian clock 1 | 0.0217893 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0217184 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0216742 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0216008 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0214853 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0213703 |
| HLA-C | major histocompatibility complex, class I, C | 0.0212378 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0208438 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0207771 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0206303 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0204951 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0204102 |
| MEF2D | myocyte enhancer factor 2D | 0.020212 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0201526 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.0201102 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0200194 |
| ATF6 | activating transcription factor 6 | 0.0197111 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0196745 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0196305 |
| RPL13A | ribosomal protein L13a | 0.0194321 |
| APP | amyloid beta (A4) precursor protein | 0.0193881 |
| SIK3 | SIK family kinase 3 | 0.0193344 |
| ATP11A | ATPase, class VI, type 11A | 0.0189465 |
| CTTN | cortactin | 0.0187577 |
| RPS27 | ribosomal protein S27 | 0.0187269 |
| CCNY | cyclin Y | 0.0187205 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0183271 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0182558 |
| STC1 | stanniocalcin 1 | 0.0182255 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0181351 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0181197 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0180853 |
| BRD2 | bromodomain containing 2 | 0.017979 |
| RPS20 | ribosomal protein S20 | 0.0179714 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0179474 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.017905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.148458 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0973343 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0953592 |
| VIM | vimentin | -0.0929885 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0910864 |
| PTMA | prothymosin, alpha | -0.0907829 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0678608 |
| MKI67 | marker of proliferation Ki-67 | -0.057317 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0545021 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0532469 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0507399 |
| PHIP | pleckstrin homology domain interacting protein | -0.0504706 |
| RAD51B | RAD51 paralog B | -0.0501081 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0489571 |
| GNAS | GNAS complex locus | -0.0468576 |
| CENPF | centromere protein F, 350/400kDa | -0.046181 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0461412 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0459938 |
| XPO1 | exportin 1 | -0.0457246 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0446593 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0430025 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0418019 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0415332 |
| TXNRD1 | thioredoxin reductase 1 | -0.0409611 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0402253 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0397184 |
| ZFR | zinc finger RNA binding protein | -0.0396776 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0388244 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0382925 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.037387 |
| BBX | bobby sox homolog (Drosophila) | -0.0369251 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0366231 |
| KIF5B | kinesin family member 5B | -0.0354356 |
| RBM39 | RNA binding motif protein 39 | -0.035191 |
| TPX2 | TPX2, microtubule-associated | -0.0348645 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0348321 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0346307 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0345263 |
| RPL5 | ribosomal protein L5 | -0.0344877 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0341187 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0333942 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0333244 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0332999 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0332406 |
| ZNF207 | zinc finger protein 207 | -0.0329693 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0328997 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0325547 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0324939 |
| CBX3 | chromobox homolog 3 | -0.0322946 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0322909 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0319892 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0316582 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0312437 |
| SGO2 | shugoshin 2 | -0.0311564 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0311054 |
| TAOK1 | TAO kinase 1 | -0.0307048 |
| CCND2 | cyclin D2 | -0.0306739 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0305854 |
| SRP72 | signal recognition particle 72kDa | -0.0303932 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.03004 |
| RPS2 | ribosomal protein S2 | -0.0299875 |
| IGF2 | insulin-like growth factor 2 | -0.029828 |
| CCND1 | cyclin D1 | -0.0298044 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.029571 |
| SP3 | Sp3 transcription factor | -0.0294525 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293398 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0290261 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0290019 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.028923 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0289068 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0287223 |
| CLTC | clathrin, heavy chain (Hc) | -0.0285125 |
| RPS24 | ribosomal protein S24 | -0.0284188 |
| RPLP0 | ribosomal protein, large, P0 | -0.0279612 |
| USP34 | ubiquitin specific peptidase 34 | -0.0278765 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0275888 |
| VCL | vinculin | -0.0275786 |
| IPO7 | importin 7 | -0.0272677 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0271172 |
| ANLN | anillin, actin binding protein | -0.0269568 |
| CENPE | centromere protein E, 312kDa | -0.0264948 |
| TUBA1B | tubulin, alpha 1b | -0.0264224 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0263711 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0262648 |
| SEPTIN7 | septin 7 | -0.0261668 |
| NUP153 | nucleoporin 153kDa | -0.0260032 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0254556 |
| SBF2 | SET binding factor 2 | -0.0251829 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0249767 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.0249237 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.024912 |
| FBXO11 | F-box protein 11 | -0.024847 |
| WBP11 | WW domain binding protein 11 | -0.0247659 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0247359 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0247268 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0247205 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.024666 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0245852 |
| NUP155 | nucleoporin 155kDa | -0.0245268 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0244869 |
