| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.247371 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.169851 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.160933 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.114202 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.101973 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0897041 |
| HLA-B | major histocompatibility complex, class I, B | 0.0893522 |
| EFNA5 | ephrin-A5 | 0.0888025 |
| LMO7 | LIM domain 7 | 0.0817017 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0796989 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0790778 |
| TXNIP | thioredoxin interacting protein | 0.0744886 |
| HLA-A | major histocompatibility complex, class I, A | 0.0716709 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0709847 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0678611 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0640362 |
| VEGFA | vascular endothelial growth factor A | 0.063804 |
| GOLGB1 | golgin B1 | 0.0619444 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0612111 |
| TPM3 | tropomyosin 3 | 0.0594582 |
| KRT8 | keratin 8, type II | 0.0518978 |
| FBXO32 | F-box protein 32 | 0.0512032 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0487235 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0481491 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0480799 |
| BRD2 | bromodomain containing 2 | 0.0474067 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0470656 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0465376 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0464945 |
| COPA | coatomer protein complex, subunit alpha | 0.0461376 |
| KRT18 | keratin 18, type I | 0.0452872 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0447518 |
| TMSB4X | thymosin beta 4, X-linked | 0.0447329 |
| DUSP10 | dual specificity phosphatase 10 | 0.0445422 |
| TCIM | transcriptional and immune response regulator | 0.0439745 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0439624 |
| CALU | calumenin | 0.0432076 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0426904 |
| LAMB3 | laminin, beta 3 | 0.0426764 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0426621 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0423326 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0415068 |
| RPL4 | ribosomal protein L4 | 0.0414442 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0405713 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0402533 |
| FAM13A | family with sequence similarity 13, member A | 0.0399162 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0392478 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0391527 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.039049 |
| TUFT1 | tuftelin 1 | 0.0389984 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.038073 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0378116 |
| HLA-E | major histocompatibility complex, class I, E | 0.037704 |
| TMF1 | TATA element modulatory factor 1 | 0.0376076 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.037155 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0371174 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0365363 |
| DHFR | dihydrofolate reductase | 0.0362991 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0361624 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0357881 |
| AOPEP | aminopeptidase O (putative) | 0.03578 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.035652 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0349244 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0344139 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0342695 |
| SON | SON DNA binding protein | 0.0342646 |
| GOLGA4 | golgin A4 | 0.0338211 |
| SVIL | supervillin | 0.0337356 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0336236 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.03354 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0332956 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0330655 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0327951 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0327473 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0327142 |
| FNIP1 | folliculin interacting protein 1 | 0.0324462 |
| APP | amyloid beta (A4) precursor protein | 0.0324132 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0323692 |
| KLHL24 | kelch-like family member 24 | 0.032341 |
| STEAP4 | STEAP family member 4 | 0.0321834 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0320236 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0314551 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0312706 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0311126 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0308536 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0301877 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0300259 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0299181 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.029638 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0296312 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0293753 |
| CCNB1 | cyclin B1 | 0.0292134 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0291638 |
| KRT7 | keratin 7, type II | 0.028964 |
| FLNB | filamin B, beta | 0.0288431 |
| RPL13A | ribosomal protein L13a | 0.0287966 |
| GOLGA2 | golgin A2 | 0.0286795 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0283792 |
| VMP1 | vacuole membrane protein 1 | 0.0283674 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0282765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.22314 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.178927 |
| ASPH | aspartate beta-hydroxylase | -0.17379 |
| HMGA1 | high mobility group AT-hook 1 | -0.151835 |
| NDRG1 | N-myc downstream regulated 1 | -0.128763 |
| POTEF | POTE ankyrin domain family, member F | -0.12012 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0997829 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0995438 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0955958 |
| FTL | ferritin, light polypeptide | -0.0826719 |
| S100A6 | S100 calcium binding protein A6 | -0.0761925 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0744112 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0723249 |
| FAM3C | family with sequence similarity 3, member C | -0.0705662 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0678364 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0646423 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.058425 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.055379 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0546952 |
| S100A10 | S100 calcium binding protein A10 | -0.0544623 |
| FOSL1 | FOS-like antigen 1 | -0.0504762 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0500465 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0484717 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0475905 |
| TXNRD1 | thioredoxin reductase 1 | -0.0471771 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0468847 |
| ANXA2 | annexin A2 | -0.045665 |
| MT2A | metallothionein 2A | -0.0449355 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.043923 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0421239 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0413484 |
| MYO6 | myosin VI | -0.0412894 |
| RYBP | RING1 and YY1 binding protein | -0.0404369 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0394786 |
| TMEM123 | transmembrane protein 123 | -0.0391514 |
| CCND1 | cyclin D1 | -0.0388223 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0381918 |
| SEPTIN7 | septin 7 | -0.0374098 |
| SLMAP | sarcolemma associated protein | -0.037374 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0373087 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0360108 |
| PTMA | prothymosin, alpha | -0.0359655 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0359418 |
| GNAS | GNAS complex locus | -0.0357772 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0353899 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0344125 |
| RTN4 | reticulon 4 | -0.0339804 |
| LDHA | lactate dehydrogenase A | -0.0334611 |
| FAM162A | family with sequence similarity 162, member A | -0.0331108 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0327499 |
| TUBA1B | tubulin, alpha 1b | -0.0325768 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0325231 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0324933 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0320992 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0316326 |
| ANXA5 | annexin A5 | -0.0314451 |
| KLF6 | Kruppel-like factor 6 | -0.030485 |
| RASA2 | RAS p21 protein activator 2 | -0.0299365 |
| NUP58 | nucleoporin 58 | -0.0298206 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0288738 |
| ATP13A3 | ATPase type 13A3 | -0.0285251 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0285006 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.028211 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0281921 |
| CHMP2B | charged multivesicular body protein 2B | -0.0277304 |
| CD44 | CD44 molecule (Indian blood group) | -0.0273266 |
| AREG | amphiregulin | -0.0271241 |
| CCNI | cyclin I | -0.0269924 |
| TFG | TRK-fused gene | -0.0269758 |
| RPLP1 | ribosomal protein, large, P1 | -0.0269054 |
| IL6ST | interleukin 6 signal transducer | -0.0267919 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0263276 |
| QKI | QKI, KH domain containing, RNA binding | -0.0263149 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0260239 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0256012 |
| G0S2 | G0/G1 switch 2 | -0.0255774 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.025458 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0253922 |
| SDC4 | syndecan 4 | -0.0250811 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0249838 |
| FN1 | fibronectin 1 | -0.0248945 |
| PAPOLA | poly(A) polymerase alpha | -0.0247778 |
| TOP1 | topoisomerase (DNA) I | -0.0245298 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0238108 |
| TMSB10 | thymosin beta 10 | -0.0237929 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0237154 |
| VDAC1 | voltage-dependent anion channel 1 | -0.023617 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0229574 |
| FERMT2 | fermitin family member 2 | -0.0224452 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0223629 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.022302 |
| RHOF | ras homolog family member F (in filopodia) | -0.0220025 |
| PFN1 | profilin 1 | -0.021908 |
| ATP11B | ATPase, class VI, type 11B | -0.0218775 |
| ECT2 | epithelial cell transforming 2 | -0.0215777 |
| CDK17 | cyclin-dependent kinase 17 | -0.0214264 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0214106 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0212958 |
| S100A11 | S100 calcium binding protein A11 | -0.0212725 |
| CORO1C | coronin, actin binding protein, 1C | -0.0212005 |
