| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0944251 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.092998 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0768081 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0629152 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0612975 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0578893 |
| PGK1 | phosphoglycerate kinase 1 | 0.0562967 |
| GRAMD1B | GRAM domain containing 1B | 0.0554735 |
| MCL1 | myeloid cell leukemia 1 | 0.055128 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0547151 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0537953 |
| EZR | ezrin | 0.0524811 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0522913 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0497287 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0489968 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0484616 |
| TPM3 | tropomyosin 3 | 0.0483592 |
| PYGL | phosphorylase, glycogen, liver | 0.0473865 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.04569 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0446819 |
| FN1 | fibronectin 1 | 0.0444488 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0439851 |
| AUTS2 | autism susceptibility candidate 2 | 0.0418826 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0407621 |
| RAD51B | RAD51 paralog B | 0.0406354 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0398586 |
| HLA-A | major histocompatibility complex, class I, A | 0.0390246 |
| PRELID2 | PRELI domain containing 2 | 0.0389049 |
| MSN | moesin | 0.0374967 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0373453 |
| NDRG1 | N-myc downstream regulated 1 | 0.0364278 |
| FMNL2 | formin-like 2 | 0.0359039 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0357179 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0353659 |
| FAM13A | family with sequence similarity 13, member A | 0.0346593 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0343322 |
| RPS6 | ribosomal protein S6 | 0.0341061 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0335331 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0330644 |
| PCBP2 | poly(rC) binding protein 2 | 0.0326452 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0323857 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0323857 |
| FLNB | filamin B, beta | 0.0323819 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0317914 |
| MAP7 | microtubule-associated protein 7 | 0.0315655 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0314799 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0307159 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0302198 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0298096 |
| DENND1A | DENN/MADD domain containing 1A | 0.0294245 |
| CDH13 | cadherin 13 | 0.0286545 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0285077 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0284868 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0282086 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0281462 |
| LSAMP | limbic system-associated membrane protein | 0.0273477 |
| XYLT1 | xylosyltransferase I | 0.0272575 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0270995 |
| CTBP2 | C-terminal binding protein 2 | 0.0270933 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0268636 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0266432 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0266112 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.02646 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0263752 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0257548 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0256363 |
| ZNF638 | zinc finger protein 638 | 0.0254551 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0254097 |
| CD109 | CD109 molecule | 0.0253778 |
| NRXN3 | neurexin 3 | 0.0252406 |
| SVIL | supervillin | 0.0249213 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0247783 |
| PKM | pyruvate kinase, muscle | 0.0244549 |
| LAMA5 | laminin, alpha 5 | 0.0243348 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0240412 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0238007 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0235668 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.023507 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0233318 |
| IL6 | interleukin 6 | 0.0233074 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0226339 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0225055 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.0223427 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0221005 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0213981 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.021383 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0212742 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0211396 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0210039 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0209345 |
| TENM2 | teneurin transmembrane protein 2 | 0.0205655 |
| SQSTM1 | sequestosome 1 | 0.0205253 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0204018 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0203697 |
| GPC6 | glypican 6 | 0.0203175 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0201766 |
| STC2 | stanniocalcin 2 | 0.0201176 |
| RPL3 | ribosomal protein L3 | 0.0199743 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0197818 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0197547 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.210027 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.141575 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.137274 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.117918 |
| GDA | guanine deaminase | -0.109315 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0954458 |
| ASPH | aspartate beta-hydroxylase | -0.0830509 |
| TMSB10 | thymosin beta 10 | -0.0814297 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0795078 |
| EFNA5 | ephrin-A5 | -0.0758542 |
| TXNRD1 | thioredoxin reductase 1 | -0.0743358 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0694287 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0677111 |
| KYNU | kynureninase | -0.0655703 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0617902 |
| VCL | vinculin | -0.0541245 |
| NEK7 | NIMA-related kinase 7 | -0.0514628 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0497004 |
| PTMA | prothymosin, alpha | -0.0486851 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0483169 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0476009 |
| GNAS | GNAS complex locus | -0.0460626 |
| CTSC | cathepsin C | -0.0460274 |
| RPS24 | ribosomal protein S24 | -0.0451849 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0447657 |
| SMYD3 | SET and MYND domain containing 3 | -0.0446955 |
| COL5A2 | collagen, type V, alpha 2 | -0.0417709 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0413808 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0411265 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0410571 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0391111 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0387711 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0386902 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.037834 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0364114 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0361644 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0358347 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0357852 |
| MYOF | myoferlin | -0.0357714 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0353154 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0345032 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0332292 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0324255 |
| RTN1 | reticulon 1 | -0.0323805 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.032198 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.031637 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0311109 |
| FTL | ferritin, light polypeptide | -0.0305603 |
| ENAH | enabled homolog (Drosophila) | -0.0294266 |
| PLCB4 | phospholipase C, beta 4 | -0.0292938 |
| MORF4L2 | mortality factor 4 like 2 | -0.0292189 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0289815 |
| PHF20 | PHD finger protein 20 | -0.0283241 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0279765 |
| LAMA1 | laminin, alpha 1 | -0.0279556 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0278966 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0278108 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0277068 |
| BMERB1 | bMERB domain containing 1 | -0.0275859 |
| RBM39 | RNA binding motif protein 39 | -0.027127 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.027016 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0267982 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0261971 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0259061 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0258738 |
| OSMR | oncostatin M receptor | -0.0257799 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0257157 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0250772 |
| SRGN | serglycin | -0.0249582 |
| NF1 | neurofibromin 1 | -0.0247134 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0246127 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0245239 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0244353 |
| RPL12 | ribosomal protein L12 | -0.0241699 |
| VIM | vimentin | -0.0240905 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0239919 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.023905 |
| WDR43 | WD repeat domain 43 | -0.0238573 |
| S100A6 | S100 calcium binding protein A6 | -0.0234396 |
| TNPO1 | transportin 1 | -0.023397 |
| ZNF804A | zinc finger protein 804A | -0.0233657 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.023256 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.0231391 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0230384 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0226304 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0224662 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0223775 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0221579 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0220704 |
| ARF1 | ADP-ribosylation factor 1 | -0.0220054 |
| NTN4 | netrin 4 | -0.0219897 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0218026 |
| CENPF | centromere protein F, 350/400kDa | -0.0217072 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0214763 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0213793 |
| KIF21A | kinesin family member 21A | -0.0212737 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.021225 |
| NRCAM | neuronal cell adhesion molecule | -0.021082 |
| NOP58 | NOP58 ribonucleoprotein | -0.0207308 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0206799 |
