| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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193 genes differentially expressed following the Raltitrexed_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.143738 |
| EMP1 | epithelial membrane protein 1 | 0.125432 |
| FAT1 | FAT atypical cadherin 1 | 0.110128 |
| INHBA | inhibin, beta A | 0.108536 |
| MMP1 | matrix metallopeptidase 1 | 0.107037 |
| DSCAM | Down syndrome cell adhesion molecule | 0.102072 |
| HMGA2 | high mobility group AT-hook 2 | 0.100887 |
| FN1 | fibronectin 1 | 0.0912169 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0892913 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0849461 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0844394 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0831859 |
| FBXO11 | F-box protein 11 | 0.082818 |
| TENM1 | teneurin transmembrane protein 1 | 0.0811729 |
| RUNX1 | runt-related transcription factor 1 | 0.0767173 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.074048 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0703891 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0687503 |
| PDE10A | phosphodiesterase 10A | 0.0668245 |
| DENND1A | DENN/MADD domain containing 1A | 0.0647773 |
| EGFR | epidermal growth factor receptor | 0.0634524 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0625894 |
| DST | dystonin | 0.0623256 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0574561 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0564161 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.055369 |
| MYO10 | myosin X | 0.0542036 |
| SMYD3 | SET and MYND domain containing 3 | 0.0539784 |
| TXNIP | thioredoxin interacting protein | 0.0524663 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0519426 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0506692 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0493583 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0480517 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0476204 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0432775 |
| USP34 | ubiquitin specific peptidase 34 | 0.0430471 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0397353 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0395276 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0369406 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0368798 |
| RORA | RAR-related orphan receptor A | 0.0363148 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0361484 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0354086 |
| RTN4 | reticulon 4 | 0.0337489 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0298316 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0295973 |
| GOLGA4 | golgin A4 | 0.0294836 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0267192 |
| SETD5 | SET domain containing 5 | 0.0258942 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0248489 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0244697 |
| EFNA5 | ephrin-A5 | 0.0231013 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0215352 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0199996 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0195201 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0192876 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0191503 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.019125 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.018973 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0188634 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.018708 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0184193 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0183829 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0178288 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0174125 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.017287 |
| RAD51B | RAD51 paralog B | 0.0168053 |
| NDRG1 | N-myc downstream regulated 1 | 0.0167476 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0162172 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0161284 |
| ANO6 | anoctamin 6 | 0.0153014 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0141889 |
| ZNF292 | zinc finger protein 292 | 0.0127005 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0124365 |
| FMN1 | formin 1 | 0.0123901 |
| ASPH | aspartate beta-hydroxylase | 0.0120123 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0114428 |
| YAP1 | Yes-associated protein 1 | 0.00850511 |
| SBF2 | SET binding factor 2 | 0.00816092 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00730748 |
| RLF | rearranged L-myc fusion | 0.00698208 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0067714 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.00634115 |
| FAM13A | family with sequence similarity 13, member A | 0.00632813 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0053527 |
| STC1 | stanniocalcin 1 | 0.00458707 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0036382 |
| NRG3 | neuregulin 3 | 0.00340439 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.00129049 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 6.43606E-4 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 2.71447E-4 |
| TPM4 | tropomyosin 4 | 1.51394E-4 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 1.32447E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.159507 |
| VIM | vimentin | -0.147825 |
| IGF2 | insulin-like growth factor 2 | -0.120129 |
| MT2A | metallothionein 2A | -0.113336 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.108059 |
| TMSB10 | thymosin beta 10 | -0.103421 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0970368 |
| PTMA | prothymosin, alpha | -0.0943127 |
| RPS8 | ribosomal protein S8 | -0.0933157 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0879773 |
| RPL23 | ribosomal protein L23 | -0.0870891 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0806043 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0800065 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0745904 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0702675 |
| RIGI | RNA sensor RIG-I | -0.065797 |
| RPLP1 | ribosomal protein, large, P1 | -0.0656209 |
| RPLP0 | ribosomal protein, large, P0 | -0.0634488 |
| MYO1E | myosin IE | -0.0633285 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0632951 |
| PARD3 | par-3 family cell polarity regulator | -0.0622685 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0571619 |
| RNF213 | ring finger protein 213 | -0.0569448 |
| VCL | vinculin | -0.0564293 |
| CCNI | cyclin I | -0.0556946 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.054347 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0515536 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0483318 |
| CDH13 | cadherin 13 | -0.047959 |
| NAV2 | neuron navigator 2 | -0.0473589 |
| RPS25 | ribosomal protein S25 | -0.0460587 |
| RPS12 | ribosomal protein S12 | -0.0456469 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0440582 |
| RPL11 | ribosomal protein L11 | -0.0423719 |
| PRKCA | protein kinase C, alpha | -0.0403019 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0393819 |
| RPL12 | ribosomal protein L12 | -0.036737 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0363525 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0362967 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0359013 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0348148 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0322866 |
| B2M | beta-2-microglobulin | -0.0322428 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0319434 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0302747 |
| NUP58 | nucleoporin 58 | -0.0299301 |
| ENO1 | enolase 1, (alpha) | -0.0298696 |
| CNKSR3 | CNKSR family member 3 | -0.0283098 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0271637 |
| PKM | pyruvate kinase, muscle | -0.0269381 |
| LMO7 | LIM domain 7 | -0.0268299 |
| SQSTM1 | sequestosome 1 | -0.0267608 |
| UBC | ubiquitin C | -0.0265496 |
| RPL34 | ribosomal protein L34 | -0.0256782 |
| ACTN4 | actinin, alpha 4 | -0.025003 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0246635 |
| TPI1 | triosephosphate isomerase 1 | -0.0242136 |
| RAB10 | RAB10, member RAS oncogene family | -0.0240445 |
| GPC6 | glypican 6 | -0.0232515 |
| RPS3 | ribosomal protein S3 | -0.023029 |
| NABP1 | nucleic acid binding protein 1 | -0.0227447 |
| ACTG1 | actin gamma 1 | -0.0223079 |
| NFIA | nuclear factor I/A | -0.0218915 |
| COL5A1 | collagen, type V, alpha 1 | -0.0217888 |
| JMJD1C | jumonji domain containing 1C | -0.0215163 |
| LAMB3 | laminin, beta 3 | -0.0213956 |
| ANXA2 | annexin A2 | -0.0201063 |
| TENM3 | teneurin transmembrane protein 3 | -0.01947 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0174852 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0167301 |
| COL5A2 | collagen, type V, alpha 2 | -0.0164764 |
| PTK2 | protein tyrosine kinase 2 | -0.0161046 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0160424 |
| PGK1 | phosphoglycerate kinase 1 | -0.0157809 |
| RPL31 | ribosomal protein L31 | -0.0152769 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0148835 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0137367 |
| FLNB | filamin B, beta | -0.0135404 |
| RBM25 | RNA binding motif protein 25 | -0.0135253 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0131478 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0116325 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0113551 |
| RPL35A | ribosomal protein L35a | -0.010947 |
| RPS6 | ribosomal protein S6 | -0.0105776 |
| DIAPH2 | diaphanous-related formin 2 | -0.0099047 |
| RPS19 | ribosomal protein S19 | -0.00963388 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.00916788 |
| SPAG9 | sperm associated antigen 9 | -0.00915076 |
| LDHA | lactate dehydrogenase A | -0.00904117 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.00892013 |
| POTEF | POTE ankyrin domain family, member F | -0.00855612 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00846185 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.00837451 |
| ANKRD11 | ankyrin repeat domain 11 | -0.00788952 |
| RPL37A | ribosomal protein L37a | -0.0076594 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.00722303 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00711629 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.00655829 |
| RPL26 | ribosomal protein L26 | -0.00633603 |
| RPS27A | ribosomal protein S27a | -0.00619678 |
