| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Raltitrexed_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | 0.113312 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0630962 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.060443 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0587882 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0581856 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0576671 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0572076 |
| CCN2 | cellular communication network factor 2 | 0.0551775 |
| H1-0 | H1.0 linker histone | 0.05498 |
| SRPK2 | SRSF protein kinase 2 | 0.0523146 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.051947 |
| APP | amyloid beta (A4) precursor protein | 0.0512008 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0497021 |
| PGK1 | phosphoglycerate kinase 1 | 0.0492067 |
| TMSB4X | thymosin beta 4, X-linked | 0.0488044 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0484792 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0482805 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0478254 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0455974 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0445941 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0440926 |
| CALR | calreticulin | 0.0439316 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0429784 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0425043 |
| RAD21 | RAD21 homolog (S. pombe) | 0.040089 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0398152 |
| CALU | calumenin | 0.0391601 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0362674 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0357913 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0357248 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0352771 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0343638 |
| SETD5 | SET domain containing 5 | 0.0341524 |
| TPM3 | tropomyosin 3 | 0.0340739 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0336387 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0333319 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0331493 |
| FN1 | fibronectin 1 | 0.0329532 |
| GLG1 | golgi glycoprotein 1 | 0.0326142 |
| MATR3 | matrin 3 | 0.0325908 |
| XPO1 | exportin 1 | 0.0317699 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0311239 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0309903 |
| ERBIN | erbb2 interacting protein | 0.0309885 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308699 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0304724 |
| SETD2 | SET domain containing 2 | 0.0291831 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0290411 |
| ANXA5 | annexin A5 | 0.029023 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0289709 |
| ZNF146 | zinc finger protein 146 | 0.0288397 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0285458 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0284471 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0282662 |
| USP22 | ubiquitin specific peptidase 22 | 0.0280975 |
| MED13L | mediator complex subunit 13-like | 0.0280951 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0279677 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0278881 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0278594 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0276536 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0274548 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0273233 |
| PLS3 | plastin 3 | 0.0271207 |
| RPL4 | ribosomal protein L4 | 0.0269368 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0267811 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0266746 |
| OPHN1 | oligophrenin 1 | 0.0265908 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0265663 |
| IGF2 | insulin-like growth factor 2 | 0.0264091 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0263075 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0262779 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0261634 |
| BRD2 | bromodomain containing 2 | 0.0261209 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0260388 |
| HMGA2 | high mobility group AT-hook 2 | 0.0260323 |
| GOLGA4 | golgin A4 | 0.0259312 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0257012 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0255589 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0254895 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0254337 |
| PRTG | protogenin | 0.0253868 |
| EVI5 | ecotropic viral integration site 5 | 0.0250038 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0248441 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0246876 |
| SET | SET nuclear proto-oncogene | 0.0246623 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0244891 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0243557 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0243144 |
| RPL3 | ribosomal protein L3 | 0.0242159 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0241407 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.024099 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0240205 |
| YAP1 | Yes-associated protein 1 | 0.023983 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0239367 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0238589 |
| ACTG1 | actin gamma 1 | 0.0236056 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0235115 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0234752 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0234669 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0234443 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.180867 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.172351 |
| PCDH9 | protocadherin 9 | -0.0953369 |
| PLPP1 | phospholipid phosphatase 1 | -0.0866625 |
| PHIP | pleckstrin homology domain interacting protein | -0.0841462 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.080763 |
| VIM | vimentin | -0.0788921 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0785517 |
| CADM2 | cell adhesion molecule 2 | -0.0763117 |
| TMSB10 | thymosin beta 10 | -0.0701588 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0677428 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0627783 |
| ITGAV | integrin, alpha V | -0.061676 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0615491 |
| NHSL1 | NHS-like 1 | -0.0594458 |
| RPS27A | ribosomal protein S27a | -0.0575966 |
| NRG1 | neuregulin 1 | -0.0568519 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0549811 |
| NEBL | nebulette | -0.0509434 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0485591 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0481143 |
| FTL | ferritin, light polypeptide | -0.0460559 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0459511 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0459059 |
| PCDH7 | protocadherin 7 | -0.0446623 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0438623 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0432531 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0432024 |
| GPC3 | glypican 3 | -0.042947 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.0420614 |
| RPLP1 | ribosomal protein, large, P1 | -0.0420338 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0410283 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0409328 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0408317 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0406371 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0395228 |
| COL5A2 | collagen, type V, alpha 2 | -0.0384345 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0383154 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0382897 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0377407 |
| RPS8 | ribosomal protein S8 | -0.0372742 |
| USP53 | ubiquitin specific peptidase 53 | -0.0365246 |
| UPP1 | uridine phosphorylase 1 | -0.0360383 |
| TRERF1 | transcriptional regulating factor 1 | -0.0352354 |
| RAI1 | retinoic acid induced 1 | -0.035003 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0348488 |
| NRXN1 | neurexin 1 | -0.0343968 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0343757 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0336767 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0325344 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0322648 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0314996 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0311872 |
| SRP54 | signal recognition particle 54kDa | -0.0306218 |
| SCFD1 | sec1 family domain containing 1 | -0.0304898 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0302392 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0302059 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0300163 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.029953 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0293415 |
| UTRN | utrophin | -0.029149 |
| RBM25 | RNA binding motif protein 25 | -0.0287783 |
| HMGB1 | high mobility group box 1 | -0.0287077 |
| CCDC88A | coiled-coil domain containing 88A | -0.0283348 |
| PTMA | prothymosin, alpha | -0.0281878 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0279772 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0278046 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0275814 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0274543 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0271666 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0269198 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0267125 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0259558 |
| TSPAN12 | tetraspanin 12 | -0.0257829 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0256126 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0255572 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0252488 |
| TEX11 | testis expressed 11 | -0.0251504 |
| POSTN | periostin, osteoblast specific factor | -0.0249814 |
| RPS24 | ribosomal protein S24 | -0.024873 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0247782 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0247524 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0246891 |
| PLCB4 | phospholipase C, beta 4 | -0.0244682 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0244262 |
| RPS25 | ribosomal protein S25 | -0.0243153 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.024222 |
| RPL37 | ribosomal protein L37 | -0.0239721 |
| MEF2C | myocyte enhancer factor 2C | -0.0239542 |
| PRELID2 | PRELI domain containing 2 | -0.0238041 |
| STAG2 | stromal antigen 2 | -0.0237909 |
| H3-3B | H3.3 histone B | -0.0235464 |
| RPS19 | ribosomal protein S19 | -0.0232839 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0232646 |
| S100A10 | S100 calcium binding protein A10 | -0.0232357 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | -0.0231288 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0229798 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0228787 |
| RBM20 | RNA binding motif protein 20 | -0.022661 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.02253 |
