| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.10827 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0947928 |
| EZR | ezrin | 0.0756805 |
| TMSB4X | thymosin beta 4, X-linked | 0.0731395 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0699988 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0686179 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0633782 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0603583 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0591883 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0572779 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0556165 |
| ZNF292 | zinc finger protein 292 | 0.0553068 |
| TXNRD1 | thioredoxin reductase 1 | 0.0538014 |
| RNF145 | ring finger protein 145 | 0.0520752 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0516342 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0509568 |
| PGK1 | phosphoglycerate kinase 1 | 0.0507534 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0507353 |
| RPL4 | ribosomal protein L4 | 0.0505426 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0488345 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0484519 |
| ZNF608 | zinc finger protein 608 | 0.0479204 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0432304 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0429402 |
| USP3 | ubiquitin specific peptidase 3 | 0.0422993 |
| QKI | QKI, KH domain containing, RNA binding | 0.0411039 |
| GOLGA4 | golgin A4 | 0.0400679 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0386305 |
| RTN4 | reticulon 4 | 0.0385515 |
| PLK2 | polo-like kinase 2 | 0.0372559 |
| FAM13A | family with sequence similarity 13, member A | 0.0367694 |
| CRY1 | cryptochrome circadian clock 1 | 0.0357532 |
| HDAC9 | histone deacetylase 9 | 0.0345374 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0339552 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0335529 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0335242 |
| NUP58 | nucleoporin 58 | 0.033422 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0329796 |
| RLF | rearranged L-myc fusion | 0.0326774 |
| TRERF1 | transcriptional regulating factor 1 | 0.0325377 |
| APP | amyloid beta (A4) precursor protein | 0.0324191 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.032399 |
| MATR3 | matrin 3 | 0.0322486 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0316856 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0313217 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0312684 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0311516 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0311374 |
| ANXA1 | annexin A1 | 0.0311285 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0305399 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0296956 |
| PDGFC | platelet derived growth factor C | 0.0293378 |
| VMP1 | vacuole membrane protein 1 | 0.0291814 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0288005 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0287533 |
| STX18 | syntaxin 18 | 0.0284459 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0283918 |
| B2M | beta-2-microglobulin | 0.0283739 |
| ACTG1 | actin gamma 1 | 0.027419 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.0270109 |
| TXNIP | thioredoxin interacting protein | 0.0263919 |
| CDC73 | cell division cycle 73 | 0.0261959 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.0261643 |
| CASC3 | cancer susceptibility candidate 3 | 0.0258572 |
| TFG | TRK-fused gene | 0.0258319 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0257934 |
| CCNL1 | cyclin L1 | 0.0254163 |
| PTK2 | protein tyrosine kinase 2 | 0.0252584 |
| JUN | jun proto-oncogene | 0.0251939 |
| CYTH3 | cytohesin 3 | 0.0251183 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.024959 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0248702 |
| DHFR | dihydrofolate reductase | 0.0245862 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0245473 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0242612 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0242602 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0239591 |
| BRD4 | bromodomain containing 4 | 0.0238819 |
| CORO1C | coronin, actin binding protein, 1C | 0.0238079 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0237461 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0236915 |
| GATA6 | GATA binding protein 6 | 0.0236535 |
| ZNF655 | zinc finger protein 655 | 0.0234466 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0233632 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0233531 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0232862 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0229969 |
| AMOTL2 | angiomotin like 2 | 0.0229128 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.022889 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0227736 |
| RHOA | ras homolog family member A | 0.0226522 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0224548 |
| WDR43 | WD repeat domain 43 | 0.0224478 |
| NOP58 | NOP58 ribonucleoprotein | 0.0221847 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0220634 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0220489 |
| TRIM44 | tripartite motif containing 44 | 0.02182 |
| DIAPH1 | diaphanous-related formin 1 | 0.0217498 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0216617 |
| POU2F1 | POU class 2 homeobox 1 | 0.0215841 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.195592 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.183361 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.176351 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.150531 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.128771 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0860479 |
| FOXP1 | forkhead box P1 | -0.0809097 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0778226 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0698716 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0697277 |
| NBEA | neurobeachin | -0.0684913 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0600355 |
| RPL35A | ribosomal protein L35a | -0.058933 |
| RPL31 | ribosomal protein L31 | -0.0556363 |
| EFNA5 | ephrin-A5 | -0.0531006 |
| EGFR | epidermal growth factor receptor | -0.0520895 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0506987 |
| RPS19 | ribosomal protein S19 | -0.0497833 |
| INTS6 | integrator complex subunit 6 | -0.0495998 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0491451 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0477164 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0473446 |
| RPLP2 | ribosomal protein, large, P2 | -0.046181 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045793 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0457251 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0455563 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0438205 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0425109 |
| RPL37A | ribosomal protein L37a | -0.0416227 |
| RPS23 | ribosomal protein S23 | -0.0407544 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0405595 |
| RPS24 | ribosomal protein S24 | -0.0403365 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379867 |
| RPL9 | ribosomal protein L9 | -0.0375049 |
| RPL34 | ribosomal protein L34 | -0.0373552 |
| RPS3 | ribosomal protein S3 | -0.0372051 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.037203 |
| CENPF | centromere protein F, 350/400kDa | -0.0367675 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0356618 |
| GLI3 | GLI family zinc finger 3 | -0.0353214 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0350202 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348596 |
| RPS25 | ribosomal protein S25 | -0.0339819 |
| BMP10 | bone morphogenetic protein 10 | -0.0339083 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0336984 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0333328 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0326326 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0325696 |
| RPS13 | ribosomal protein S13 | -0.0325104 |
| CANX | calnexin | -0.0318884 |
| PDE7B | phosphodiesterase 7B | -0.0317099 |
| RPS21 | ribosomal protein S21 | -0.0314315 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0311795 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.031088 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0309078 |
| NEBL | nebulette | -0.0306652 |
| RPS11 | ribosomal protein S11 | -0.0305563 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0305453 |
| CENPE | centromere protein E, 312kDa | -0.0305218 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0303056 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0301086 |
| NFIA | nuclear factor I/A | -0.0296915 |
| DIAPH3 | diaphanous-related formin 3 | -0.0292924 |
| RPL23 | ribosomal protein L23 | -0.0292704 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0291141 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.028849 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0287998 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0281428 |
| S100A10 | S100 calcium binding protein A10 | -0.0276819 |
| RPS12 | ribosomal protein S12 | -0.0276647 |
| RPL36A | ribosomal protein L36a | -0.027595 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.027576 |
| RPS27A | ribosomal protein S27a | -0.0273331 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0271915 |
| AEBP2 | AE binding protein 2 | -0.02688 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0268537 |
| CALR | calreticulin | -0.0267621 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0267351 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0267212 |
| PHF14 | PHD finger protein 14 | -0.0266553 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0266339 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0264205 |
| RPS29 | ribosomal protein S29 | -0.0264179 |
| PCNX4 | pecanex 4 | -0.0262977 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0262939 |
| EHBP1 | EH domain binding protein 1 | -0.0262924 |
| RPL30 | ribosomal protein L30 | -0.0260175 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0260073 |
| SEPTIN9 | septin 9 | -0.0258541 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0257646 |
| ATXN2 | ataxin 2 | -0.0257447 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0256966 |
| DPYD | dihydropyrimidine dehydrogenase | -0.025003 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | -0.0250017 |
| NF1 | neurofibromin 1 | -0.0249635 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0248763 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0247561 |
| TAOK1 | TAO kinase 1 | -0.024668 |
| RPL26 | ribosomal protein L26 | -0.0243393 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0243232 |
