| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.139168 |
| COL6A3 | collagen, type VI, alpha 3 | 0.121353 |
| ADM | adrenomedullin | 0.1184 |
| VEGFA | vascular endothelial growth factor A | 0.114857 |
| NDRG1 | N-myc downstream regulated 1 | 0.106666 |
| HLA-B | major histocompatibility complex, class I, B | 0.0999968 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0938011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0916848 |
| HLA-A | major histocompatibility complex, class I, A | 0.0903896 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0876703 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0702118 |
| SMAD3 | SMAD family member 3 | 0.069711 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0691218 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0681391 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.066981 |
| NAV2 | neuron navigator 2 | 0.0652119 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0631452 |
| PGK1 | phosphoglycerate kinase 1 | 0.0625479 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0616267 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0607634 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0597992 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0588334 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0573241 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0567467 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0548076 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0532408 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0512649 |
| PLIN2 | perilipin 2 | 0.0503068 |
| ZNF292 | zinc finger protein 292 | 0.0502165 |
| B2M | beta-2-microglobulin | 0.0497163 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.049257 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0490325 |
| LDHA | lactate dehydrogenase A | 0.0480486 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0470257 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0467803 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0452802 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.04497 |
| SQSTM1 | sequestosome 1 | 0.0448429 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0441041 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0435328 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0429797 |
| MSN | moesin | 0.0426138 |
| STC1 | stanniocalcin 1 | 0.0419834 |
| PDE10A | phosphodiesterase 10A | 0.0419538 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0398607 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0397418 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0394897 |
| STC2 | stanniocalcin 2 | 0.0392542 |
| MMP12 | matrix metallopeptidase 12 | 0.0382413 |
| TRAM2 | translocation associated membrane protein 2 | 0.0376566 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0376453 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0371032 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0368933 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0366306 |
| C3 | complement component 3 | 0.0362143 |
| PRELID2 | PRELI domain containing 2 | 0.0362138 |
| CEP250 | centrosomal protein 250kDa | 0.0355612 |
| RND3 | Rho family GTPase 3 | 0.0347183 |
| LOXL2 | lysyl oxidase-like 2 | 0.0345938 |
| ARRDC3 | arrestin domain containing 3 | 0.0343689 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.033826 |
| RUNX1 | runt-related transcription factor 1 | 0.0337309 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.033068 |
| ARFGEF3 | ARFGEF family member 3 | 0.032585 |
| MT2A | metallothionein 2A | 0.0325748 |
| MLPH | melanophilin | 0.0325184 |
| EGFR | epidermal growth factor receptor | 0.0317777 |
| OPTN | optineurin | 0.0317766 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0317337 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0304425 |
| HDAC9 | histone deacetylase 9 | 0.0303908 |
| CDCP1 | CUB domain containing protein 1 | 0.0301192 |
| PHF21A | PHD finger protein 21A | 0.0300856 |
| TPM3 | tropomyosin 3 | 0.0297593 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0297011 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0294903 |
| SFTPA2 | surfactant protein A2 | 0.0288669 |
| FAM13A | family with sequence similarity 13, member A | 0.0286889 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0285737 |
| TNS3 | tensin 3 | 0.0284267 |
| MYO10 | myosin X | 0.0281191 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0280256 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0279355 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0275718 |
| FAM219A | family with sequence similarity 219, member A | 0.0273354 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0272622 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0270798 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0266067 |
| SMYD3 | SET and MYND domain containing 3 | 0.0264621 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0264281 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0260125 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0259252 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0258505 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0257281 |
| HLA-C | major histocompatibility complex, class I, C | 0.0256788 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0255892 |
| PCBP2 | poly(rC) binding protein 2 | 0.0254751 |
| EGR1 | early growth response 1 | 0.0249375 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0249138 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0249002 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.220749 |
| VCL | vinculin | -0.118453 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.090662 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0814441 |
| FN1 | fibronectin 1 | -0.0793328 |
| IER3 | immediate early response 3 | -0.0793027 |
| RPS24 | ribosomal protein S24 | -0.075434 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0656726 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0644389 |
| PTMA | prothymosin, alpha | -0.0619965 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0617356 |
| BICC1 | BicC family RNA binding protein 1 | -0.0600079 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0586619 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.057957 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0564487 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.05483 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0512664 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0484749 |
| TMSB10 | thymosin beta 10 | -0.0473684 |
| THBS1 | thrombospondin 1 | -0.0471813 |
| FRMD4A | FERM domain containing 4A | -0.0465175 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0461061 |
| GNAS | GNAS complex locus | -0.0445804 |
| PALLD | palladin, cytoskeletal associated protein | -0.0437839 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0435726 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0405844 |
| GLIS3 | GLIS family zinc finger 3 | -0.0400175 |
| ANXA2 | annexin A2 | -0.0386782 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0373027 |
| WTAP | Wilms tumor 1 associated protein | -0.036392 |
| TPM4 | tropomyosin 4 | -0.0362001 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0354795 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0350144 |
| KLF6 | Kruppel-like factor 6 | -0.0346173 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0338878 |
| TKT | transketolase | -0.0331032 |
| COL1A1 | collagen, type I, alpha 1 | -0.0326504 |
| SRGN | serglycin | -0.0323921 |
| RPS21 | ribosomal protein S21 | -0.031404 |
| MORF4L2 | mortality factor 4 like 2 | -0.031144 |
| RPL32 | ribosomal protein L32 | -0.0310756 |
| NABP1 | nucleic acid binding protein 1 | -0.0308234 |
| SP100 | SP100 nuclear antigen | -0.0303606 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0302048 |
| RPS4X | ribosomal protein S4, X-linked | -0.0301394 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0299085 |
| RASAL2 | RAS protein activator like 2 | -0.0297205 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0292733 |
| TMEM123 | transmembrane protein 123 | -0.029149 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0290489 |
| TUBB | tubulin, beta class I | -0.0286767 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0282207 |
| ZNF207 | zinc finger protein 207 | -0.0281228 |
| RPL19 | ribosomal protein L19 | -0.0280527 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0279402 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0272573 |
| RPL26 | ribosomal protein L26 | -0.0270453 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0268711 |
| FTL | ferritin, light polypeptide | -0.0265369 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0264645 |
| CUL4B | cullin 4B | -0.0262632 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0259932 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0259551 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0258466 |
| RPL36A | ribosomal protein L36a | -0.0257525 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0253953 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.025296 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0252799 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0250506 |
| POTEF | POTE ankyrin domain family, member F | -0.0249289 |
| MKI67 | marker of proliferation Ki-67 | -0.0246234 |
| RBM39 | RNA binding motif protein 39 | -0.024531 |
| RTN4 | reticulon 4 | -0.0244799 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.0244408 |
| DENND5A | DENN/MADD domain containing 5A | -0.0243067 |
| SERINC1 | serine incorporator 1 | -0.0242443 |
| RPL35A | ribosomal protein L35a | -0.0241524 |
| RPLP1 | ribosomal protein, large, P1 | -0.0241451 |
| RPLP0 | ribosomal protein, large, P0 | -0.024056 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.023931 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0239192 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0239124 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023731 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0233929 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0233678 |
| SMAD2 | SMAD family member 2 | -0.0233614 |
| SDC4 | syndecan 4 | -0.0231396 |
| RIGI | RNA sensor RIG-I | -0.0230973 |
| RPL6 | ribosomal protein L6 | -0.0230237 |
| TMEM263 | transmembrane protein 263 | -0.0230022 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.022944 |
| RHEB | Ras homolog enriched in brain | -0.022943 |
| DIAPH3 | diaphanous-related formin 3 | -0.0229031 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0226215 |
| SBF2 | SET binding factor 2 | -0.0225649 |
| NPR2 | natriuretic peptide receptor 2 | -0.0224845 |
| RPL23 | ribosomal protein L23 | -0.0224827 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0221332 |
| CAVIN1 | caveolae associated protein 1 | -0.0220735 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0219808 |
