| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.158807 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.140963 |
| FAM13A | family with sequence similarity 13, member A | 0.088881 |
| ADM | adrenomedullin | 0.0745917 |
| GRB10 | growth factor receptor-bound protein 10 | 0.071321 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0707946 |
| PGK1 | phosphoglycerate kinase 1 | 0.0680878 |
| COL7A1 | collagen, type VII, alpha 1 | 0.065515 |
| HLA-B | major histocompatibility complex, class I, B | 0.0640985 |
| KYNU | kynureninase | 0.0616979 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0607391 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0600874 |
| ATXN1 | ataxin 1 | 0.0597811 |
| EXOC4 | exocyst complex component 4 | 0.0590986 |
| NRXN3 | neurexin 3 | 0.057344 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0567713 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0549481 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0549219 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0528057 |
| COL6A3 | collagen, type VI, alpha 3 | 0.052676 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0519519 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.051391 |
| FLNA | filamin A, alpha | 0.0506632 |
| COPA | coatomer protein complex, subunit alpha | 0.0505844 |
| HLA-C | major histocompatibility complex, class I, C | 0.0502294 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0502222 |
| ANO6 | anoctamin 6 | 0.050149 |
| GOLGB1 | golgin B1 | 0.0498787 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.049336 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0487328 |
| PRELID2 | PRELI domain containing 2 | 0.0484842 |
| FLNB | filamin B, beta | 0.0477989 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.04702 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0463417 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.046091 |
| RUNX1 | runt-related transcription factor 1 | 0.0456204 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.045269 |
| FRMD4A | FERM domain containing 4A | 0.0439465 |
| DSCAM | Down syndrome cell adhesion molecule | 0.043627 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0433606 |
| NAV2 | neuron navigator 2 | 0.0431565 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0431101 |
| SEPTIN9 | septin 9 | 0.0421008 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0414967 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0406608 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0402236 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0400878 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0397076 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0392482 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0390725 |
| SQSTM1 | sequestosome 1 | 0.0388328 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0385073 |
| EFNA5 | ephrin-A5 | 0.0384487 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0383777 |
| EHBP1 | EH domain binding protein 1 | 0.0381667 |
| ZNF638 | zinc finger protein 638 | 0.0377725 |
| VEGFA | vascular endothelial growth factor A | 0.0376903 |
| TPR | translocated promoter region, nuclear basket protein | 0.0376764 |
| HIP1 | huntingtin interacting protein 1 | 0.0370137 |
| CDH13 | cadherin 13 | 0.0365629 |
| SON | SON DNA binding protein | 0.0353196 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.034887 |
| TNS3 | tensin 3 | 0.0347658 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0342619 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0341088 |
| HELZ | helicase with zinc finger | 0.0337621 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0335973 |
| NDRG1 | N-myc downstream regulated 1 | 0.0328842 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0327078 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0326366 |
| ENO1 | enolase 1, (alpha) | 0.0326357 |
| PDGFC | platelet derived growth factor C | 0.032401 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0318062 |
| UBC | ubiquitin C | 0.031758 |
| FAM20C | family with sequence similarity 20, member C | 0.0316072 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0315621 |
| HLA-A | major histocompatibility complex, class I, A | 0.0313869 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0312446 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0309592 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0308793 |
| INTS6 | integrator complex subunit 6 | 0.0306927 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0306578 |
| PLEC | plectin | 0.0301827 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0299967 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0299032 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0298448 |
| FTO | fat mass and obesity associated | 0.0297756 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0294486 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.02933 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0287686 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0287209 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0286213 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0285867 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0285284 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0282973 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0276552 |
| SP100 | SP100 nuclear antigen | 0.0274611 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0274287 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0271529 |
| RIOK3 | RIO kinase 3 | 0.02713 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.11372 |
| PTMA | prothymosin, alpha | -0.104918 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0974309 |
| COL1A2 | collagen, type I, alpha 2 | -0.0848422 |
| VIM | vimentin | -0.0848026 |
| FN1 | fibronectin 1 | -0.0791292 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0784882 |
| B2M | beta-2-microglobulin | -0.0776887 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.065682 |
| LOX | lysyl oxidase | -0.0594282 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0541744 |
| PKM | pyruvate kinase, muscle | -0.0534126 |
| SMYD3 | SET and MYND domain containing 3 | -0.0505147 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0498754 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0469244 |
| PTN | pleiotrophin | -0.0461318 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.046103 |
| H3-3B | H3.3 histone B | -0.0452093 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0449494 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.04452 |
| RPL11 | ribosomal protein L11 | -0.0438332 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0427087 |
| RNF24 | ring finger protein 24 | -0.0425688 |
| SEPTIN7 | septin 7 | -0.0414844 |
| MEF2A | myocyte enhancer factor 2A | -0.041263 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0412165 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0406147 |
| GNAS | GNAS complex locus | -0.0395806 |
| PRSS23 | protease, serine, 23 | -0.0395751 |
| RPS2 | ribosomal protein S2 | -0.0381934 |
| RPL32 | ribosomal protein L32 | -0.0381416 |
| TFG | TRK-fused gene | -0.0374989 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0373802 |
| THBS1 | thrombospondin 1 | -0.0372197 |
| RPS8 | ribosomal protein S8 | -0.0368981 |
| PFN1 | profilin 1 | -0.0368122 |
| WDR45B | WD repeat domain 45B | -0.0363184 |
| RPL34 | ribosomal protein L34 | -0.0356203 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.0355277 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0353 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0351635 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.035054 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0349847 |
| RPL37 | ribosomal protein L37 | -0.0346692 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0346068 |
| RPS24 | ribosomal protein S24 | -0.0339475 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0337554 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0335045 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0334898 |
| CALD1 | caldesmon 1 | -0.0332395 |
| SRPK2 | SRSF protein kinase 2 | -0.0332389 |
| MTPN | myotrophin | -0.031819 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0318087 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.031771 |
| SDC4 | syndecan 4 | -0.0316571 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0312918 |
| KIF5B | kinesin family member 5B | -0.0312457 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0304264 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0303178 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0301632 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0295495 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0294518 |
| JAG1 | jagged 1 | -0.0293833 |
| POTEF | POTE ankyrin domain family, member F | -0.02938 |
| COL1A1 | collagen, type I, alpha 1 | -0.0292256 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0288596 |
| CD44 | CD44 molecule (Indian blood group) | -0.0286892 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0284842 |
| RPL26 | ribosomal protein L26 | -0.0284561 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0284464 |
| SEC24D | SEC24 family member D | -0.0281403 |
| FTL | ferritin, light polypeptide | -0.027893 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0275005 |
| FOXJ3 | forkhead box J3 | -0.0274941 |
| RAI1 | retinoic acid induced 1 | -0.0274863 |
| CCDC88A | coiled-coil domain containing 88A | -0.0272781 |
| TMEM59 | transmembrane protein 59 | -0.0270104 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0268275 |
| PHF21A | PHD finger protein 21A | -0.0267649 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0263547 |
| RBM6 | RNA binding motif protein 6 | -0.0263229 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0260788 |
| BSG | basigin (Ok blood group) | -0.0260296 |
| CLMP | CXADR-like membrane protein | -0.0259617 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0259567 |
| MED13L | mediator complex subunit 13-like | -0.0259562 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0259546 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0258459 |
| JAK1 | Janus kinase 1 | -0.0257772 |
| RACK1 | receptor for activated C kinase 1 | -0.0257727 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0257539 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0256558 |
| RPL19 | ribosomal protein L19 | -0.0255801 |
| TAOK1 | TAO kinase 1 | -0.0255325 |
| ARRDC3 | arrestin domain containing 3 | -0.0254142 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0253227 |
| PDS5B | PDS5 cohesin associated factor B | -0.0252749 |
| TXNIP | thioredoxin interacting protein | -0.0251864 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0251088 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0247912 |
