| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.10664 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0708268 |
| SVIL | supervillin | 0.0581552 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0555629 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0539477 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0524059 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.051913 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0498406 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0484264 |
| ZNF638 | zinc finger protein 638 | 0.0450701 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.043085 |
| SMAD3 | SMAD family member 3 | 0.0418473 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0391798 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.039012 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0384975 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0383593 |
| ATXN1 | ataxin 1 | 0.038356 |
| TXNIP | thioredoxin interacting protein | 0.0367238 |
| FMNL2 | formin-like 2 | 0.0365538 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0360316 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0353469 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0345435 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0331455 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0314058 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0309207 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0308832 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0306205 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.0302377 |
| ZNF292 | zinc finger protein 292 | 0.0300947 |
| GOLGA4 | golgin A4 | 0.0300669 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0297525 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0295508 |
| PRR16 | proline rich 16 | 0.0289141 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0288514 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0281121 |
| ANGPTL4 | angiopoietin-like 4 | 0.0275233 |
| PLEC | plectin | 0.0269304 |
| SQSTM1 | sequestosome 1 | 0.0268848 |
| NPTN | neuroplastin | 0.026879 |
| TUT7 | terminal uridylyl transferase 7 | 0.0268037 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.026589 |
| ITSN2 | intersectin 2 | 0.0263813 |
| EZR | ezrin | 0.0263466 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0258562 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0255921 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0254685 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0251011 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0249807 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0247822 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0246118 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0244083 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0242035 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0240599 |
| AFDN | afadin, adherens junction formation factor | 0.0239774 |
| GPHN | gephyrin | 0.0237296 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.0235696 |
| RIGI | RNA sensor RIG-I | 0.0234867 |
| RBM25 | RNA binding motif protein 25 | 0.0231447 |
| BMERB1 | bMERB domain containing 1 | 0.0227554 |
| RNF145 | ring finger protein 145 | 0.0225131 |
| NGLY1 | N-glycanase 1 | 0.0224825 |
| SMYD3 | SET and MYND domain containing 3 | 0.0224533 |
| RPS12 | ribosomal protein S12 | 0.0223527 |
| PGK1 | phosphoglycerate kinase 1 | 0.0222632 |
| ATRN | attractin | 0.0220376 |
| ANO6 | anoctamin 6 | 0.0219553 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0216987 |
| SPAG9 | sperm associated antigen 9 | 0.0215636 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0214571 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.021427 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0214236 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.021374 |
| DIAPH1 | diaphanous-related formin 1 | 0.0213733 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0213715 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0210989 |
| SLC35F2 | solute carrier family 35, member F2 | 0.0210428 |
| RPL35A | ribosomal protein L35a | 0.0210325 |
| PHF21A | PHD finger protein 21A | 0.0209778 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0208714 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0208001 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0206311 |
| TMEM14B | transmembrane protein 14B | 0.0206003 |
| PHF3 | PHD finger protein 3 | 0.0205239 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0205197 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0204931 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0204809 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0204449 |
| JMJD1C | jumonji domain containing 1C | 0.0203365 |
| ARRDC3 | arrestin domain containing 3 | 0.0202558 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.020141 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0200271 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.019997 |
| RORA | RAR-related orphan receptor A | 0.0199477 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0198835 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0198178 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0197936 |
| TMEM245 | transmembrane protein 245 | 0.019688 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.0196638 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0196293 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0195671 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.119021 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0581379 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0488891 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0473231 |
| VCL | vinculin | -0.0440552 |
| DTNA | dystrobrevin, alpha | -0.0429366 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0417944 |
| POTEF | POTE ankyrin domain family, member F | -0.0416467 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0388874 |
| MT2A | metallothionein 2A | -0.0383702 |
| DNER | delta/notch-like EGF repeat containing | -0.0379803 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.037896 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0374587 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0360307 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.034176 |
| GLG1 | golgi glycoprotein 1 | -0.0337538 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0335788 |
| LDHA | lactate dehydrogenase A | -0.0324781 |
| HMGA2 | high mobility group AT-hook 2 | -0.0298407 |
| GNAS | GNAS complex locus | -0.0296582 |
| PTMA | prothymosin, alpha | -0.0296423 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0292118 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0288881 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0286382 |
| TAOK1 | TAO kinase 1 | -0.0274555 |
| PFN1 | profilin 1 | -0.0270796 |
| LAMA5 | laminin, alpha 5 | -0.0269269 |
| TMEM123 | transmembrane protein 123 | -0.0266801 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0265649 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.0254017 |
| CLTC | clathrin, heavy chain (Hc) | -0.0239488 |
| ADNP | activity-dependent neuroprotector homeobox | -0.023662 |
| CENPF | centromere protein F, 350/400kDa | -0.0234752 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0234169 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0233812 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0232606 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0230544 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0229585 |
| SNX14 | sorting nexin 14 | -0.0229221 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0229111 |
| TPX2 | TPX2, microtubule-associated | -0.0227833 |
| PKM | pyruvate kinase, muscle | -0.0225861 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0222598 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0221788 |
| EGR1 | early growth response 1 | -0.0221717 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0221124 |
| AHNAK | AHNAK nucleoprotein | -0.0220638 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0219702 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0219403 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0215942 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0215584 |
| FTL | ferritin, light polypeptide | -0.0215482 |
| THBS1 | thrombospondin 1 | -0.0215455 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.02107 |
| STK4 | serine/threonine kinase 4 | -0.0210013 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0209515 |
| SCFD1 | sec1 family domain containing 1 | -0.0209076 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.02088 |
| RPL36AL | ribosomal protein L36a-like | -0.0208772 |
| ZNF721 | zinc finger protein 721 | -0.0207365 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0205106 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.020494 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0201986 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.020064 |
| TPM4 | tropomyosin 4 | -0.0199462 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0198724 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0196568 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0195713 |
| NLK | nemo-like kinase | -0.0195313 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0193755 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0190099 |
| PTGES2 | prostaglandin E synthase 2 | -0.0189507 |
| CDK14 | cyclin-dependent kinase 14 | -0.0188477 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.0188147 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0187497 |
| MDM4 | MDM4, p53 regulator | -0.0187295 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0186722 |
| CENPE | centromere protein E, 312kDa | -0.0183762 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0183176 |
| INTS6 | integrator complex subunit 6 | -0.0182935 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0182903 |
| QKI | QKI, KH domain containing, RNA binding | -0.0182758 |
| ZNF217 | zinc finger protein 217 | -0.0182485 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.018196 |
| ECT2 | epithelial cell transforming 2 | -0.0180729 |
| KLC1 | kinesin light chain 1 | -0.0179856 |
| KIF4A | kinesin family member 4A | -0.0178575 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0178019 |
| SGO2 | shugoshin 2 | -0.0177294 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0177141 |
| WWC1 | WW and C2 domain containing 1 | -0.0176775 |
| TPI1 | triosephosphate isomerase 1 | -0.017675 |
| OSMR | oncostatin M receptor | -0.0176685 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0176509 |
| EP300 | E1A binding protein p300 | -0.0175737 |
| PHF20 | PHD finger protein 20 | -0.0175547 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0174902 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0174125 |
| PKN2 | protein kinase N2 | -0.0173907 |
| FERMT2 | fermitin family member 2 | -0.0173839 |
