| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Raltitrexed perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Raltitrexed_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.139834 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0809543 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0782507 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0739271 |
| FAM13A | family with sequence similarity 13, member A | 0.0640771 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0631215 |
| EZR | ezrin | 0.0621989 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0612496 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0567833 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0550723 |
| SFTPA2 | surfactant protein A2 | 0.0538011 |
| HLA-B | major histocompatibility complex, class I, B | 0.0532293 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0529615 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0526972 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0510979 |
| STC2 | stanniocalcin 2 | 0.0507482 |
| EMP1 | epithelial membrane protein 1 | 0.0502669 |
| ATF3 | activating transcription factor 3 | 0.0499843 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0498231 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0478202 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.047497 |
| SVIL | supervillin | 0.0472858 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0434939 |
| RND3 | Rho family GTPase 3 | 0.0428416 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0422995 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0421775 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0411714 |
| AOPEP | aminopeptidase O (putative) | 0.0408491 |
| MLF1 | myeloid leukemia factor 1 | 0.0407483 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0406979 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0403732 |
| SIK3 | SIK family kinase 3 | 0.0401153 |
| LMNA | lamin A/C | 0.0401077 |
| SGMS2 | sphingomyelin synthase 2 | 0.0395337 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.039073 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0386596 |
| SIRT1 | sirtuin 1 | 0.0384777 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0384545 |
| SQSTM1 | sequestosome 1 | 0.0382668 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0379585 |
| DUSP6 | dual specificity phosphatase 6 | 0.0375888 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0371479 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0361463 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0350634 |
| FAT1 | FAT atypical cadherin 1 | 0.0350163 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0347418 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0345887 |
| TCIM | transcriptional and immune response regulator | 0.0339629 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0337156 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0336669 |
| TPM3 | tropomyosin 3 | 0.0335824 |
| CRY1 | cryptochrome circadian clock 1 | 0.0335805 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0334355 |
| SUCO | SUN domain containing ossification factor | 0.0331865 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0318332 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0318102 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0314606 |
| PER2 | period circadian clock 2 | 0.0314586 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0309468 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0303254 |
| FAM107B | family with sequence similarity 107, member B | 0.0291931 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0290968 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0288985 |
| HLA-A | major histocompatibility complex, class I, A | 0.0285387 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0277313 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0274875 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0273884 |
| CTBP2 | C-terminal binding protein 2 | 0.0270452 |
| PLEC | plectin | 0.0266217 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0264473 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0263933 |
| DSTN | destrin (actin depolymerizing factor) | 0.0263176 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0261395 |
| NEBL | nebulette | 0.0260182 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.0252674 |
| B2M | beta-2-microglobulin | 0.0250318 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.024973 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0249583 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0246955 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 0.0246868 |
| ARFGEF3 | ARFGEF family member 3 | 0.0245215 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0239801 |
| DHFR | dihydrofolate reductase | 0.0238223 |
| HLA-C | major histocompatibility complex, class I, C | 0.0235116 |
| TPR | translocated promoter region, nuclear basket protein | 0.0234997 |
| TMF1 | TATA element modulatory factor 1 | 0.0233358 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0232429 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0230464 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0228962 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0226423 |
| DENND5B | DENN/MADD domain containing 5B | 0.0223899 |
| RAI14 | retinoic acid induced 14 | 0.0223077 |
| MEF2D | myocyte enhancer factor 2D | 0.0219945 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0219644 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0218972 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0218688 |
| TXNIP | thioredoxin interacting protein | 0.0218613 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0212548 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0212456 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0211189 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.171722 |
| VCL | vinculin | -0.170255 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.159199 |
| HMGA2 | high mobility group AT-hook 2 | -0.138353 |
| FN1 | fibronectin 1 | -0.134217 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.133292 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0973574 |
| VIM | vimentin | -0.0970398 |
| PTMA | prothymosin, alpha | -0.0802821 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0732472 |
| TMSB10 | thymosin beta 10 | -0.0690505 |
| INTS6 | integrator complex subunit 6 | -0.069034 |
| AEBP2 | AE binding protein 2 | -0.068873 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0599379 |
| NTN4 | netrin 4 | -0.0590683 |
| SYT1 | synaptotagmin I | -0.057354 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.054383 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0533621 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0518259 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0505359 |
| ASPH | aspartate beta-hydroxylase | -0.0499644 |
| POTEF | POTE ankyrin domain family, member F | -0.0488082 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0484915 |
| GNAS | GNAS complex locus | -0.0476404 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0476216 |
| PDLIM5 | PDZ and LIM domain 5 | -0.046533 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.046402 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0445852 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0439182 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0438843 |
| PKM | pyruvate kinase, muscle | -0.0434972 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0431924 |
| CANX | calnexin | -0.0426057 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0413227 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.040967 |
| PALLD | palladin, cytoskeletal associated protein | -0.0399051 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0392661 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0389113 |
| IER3 | immediate early response 3 | -0.0387733 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0386074 |
| S100A6 | S100 calcium binding protein A6 | -0.0385327 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0382821 |
| ZNF217 | zinc finger protein 217 | -0.0377387 |
| SPAG9 | sperm associated antigen 9 | -0.0366622 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.035647 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0353771 |
| RCOR1 | REST corepressor 1 | -0.0347583 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0345716 |
| VMP1 | vacuole membrane protein 1 | -0.0343358 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0336624 |
| PRELID2 | PRELI domain containing 2 | -0.0330571 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0328403 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0323379 |
| ACTN1 | actinin, alpha 1 | -0.0319042 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0315892 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0314251 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0312711 |
| ACTN4 | actinin, alpha 4 | -0.0310061 |
| DST | dystonin | -0.030837 |
| TPI1 | triosephosphate isomerase 1 | -0.0305622 |
| ANLN | anillin, actin binding protein | -0.0303252 |
| RBM39 | RNA binding motif protein 39 | -0.0301359 |
| PUM2 | pumilio RNA-binding family member 2 | -0.030118 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0299053 |
| CLTC | clathrin, heavy chain (Hc) | -0.0297492 |
| SEPTIN7 | septin 7 | -0.029578 |
| S100A10 | S100 calcium binding protein A10 | -0.0294581 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0292771 |
| TSC22D1 | TSC22 domain family, member 1 | -0.029059 |
| UBXN4 | UBX domain protein 4 | -0.0288933 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0287635 |
| RNF213 | ring finger protein 213 | -0.0286792 |
| RPS24 | ribosomal protein S24 | -0.0286674 |
| TUFT1 | tuftelin 1 | -0.0280241 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0278165 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0277075 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0276717 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0274326 |
| FAM20C | family with sequence similarity 20, member C | -0.0274054 |
| PCBP2 | poly(rC) binding protein 2 | -0.0272818 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0272093 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0271952 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0265759 |
| GLIS3 | GLIS family zinc finger 3 | -0.026452 |
| RAB31 | RAB31, member RAS oncogene family | -0.0262923 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0260972 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.025939 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0259113 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0258769 |
| CENPF | centromere protein F, 350/400kDa | -0.0258544 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0257574 |
| MKI67 | marker of proliferation Ki-67 | -0.025614 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0254824 |
| MYOF | myoferlin | -0.0253066 |
| HMGA1 | high mobility group AT-hook 1 | -0.0251472 |
| NAV1 | neuron navigator 1 | -0.0251466 |
| WDR1 | WD repeat domain 1 | -0.0247976 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.02473 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0245604 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0245178 |
