Ramelteon Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/208902
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Genes

196 proteins with high or low expression in Ramelteon relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 1.46
ALPK3 alpha-kinase 3 1.03
VAV1 vav 1 guanine nucleotide exchange factor 1.03
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.93
RPS25 ribosomal protein S25 0.92
MT1X metallothionein 1X 0.87
PIP prolactin-induced protein 0.86
H1-2 H1.2 linker histone, cluster member 0.85
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.79
CCDC158 coiled-coil domain containing 158 0.76
MITD1 MIT, microtubule interacting and transport, domain containing 1 0.74
ZNF652 zinc finger protein 652 0.74
TBCA tubulin folding cofactor A 0.73
TPM3 tropomyosin 3 0.7
SBSN suprabasin 0.69
TPM4 tropomyosin 4 0.68
RPL36AL ribosomal protein L36a-like 0.68
BBS9 Bardet-Biedl syndrome 9 0.66
RPL23A ribosomal protein L23a 0.63
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 0.62
KMT2B lysine (K)-specific methyltransferase 2B 0.6
STMN2 stathmin 2 0.56
PKM pyruvate kinase, muscle 0.56
DYNLT3 dynein, light chain, Tctex-type 3 0.55
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.54
BAG3 BCL2-associated athanogene 3 0.54
C11ORF49 chromosome 11 open reading frame 49 0.53
PRDX1 peroxiredoxin 1 0.52
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.52
S100A2 S100 calcium binding protein A2 0.52
RPS14 ribosomal protein S14 0.51
RPS26 ribosomal protein S26 0.51
ZYX zyxin 0.51
CAPZB capping protein (actin filament) muscle Z-line, beta 0.51
ANXA2 annexin A2 0.5
NAV2 neuron navigator 2 0.5
JPT1 Jupiter microtubule associated homolog 1 0.5
RPS18 ribosomal protein S18 0.5
RPL12 ribosomal protein L12 0.49
CFL1 cofilin 1 (non-muscle) 0.48
TPM1 tropomyosin 1 (alpha) 0.48
TPM2 tropomyosin 2 (beta) 0.47
STMN1 stathmin 1 0.47
DOCK3 dedicator of cytokinesis 3 0.47
RPS20 ribosomal protein S20 0.47
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.47
WTAP Wilms tumor 1 associated protein 0.46
RPL18A ribosomal protein L18a 0.46
S100A6 S100 calcium binding protein A6 0.46
HIST2H2BC histone cluster 2, H2bc (pseudogene) 0.45
RPLP2 ribosomal protein, large, P2 0.45
HMGB1 high mobility group box 1 0.44
RPL28 ribosomal protein L28 0.44
CCDC57 coiled-coil domain containing 57 0.43
DERPC DERPC proline and glycine rich nuclear protein 0.43
RPS3 ribosomal protein S3 0.43
ZNF627 zinc finger protein 627 0.43
OSTF1 osteoclast stimulating factor 1 0.43
METAP2 methionyl aminopeptidase 2 0.42
SPOPL speckle-type POZ protein-like 0.42
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.42
ENO3 enolase 3 (beta, muscle) 0.42
FUBP1 far upstream element (FUSE) binding protein 1 0.42
ANO8 anoctamin 8 0.41
RPL17 ribosomal protein L17 0.41
ZNF428 zinc finger protein 428 0.41
KHSRP KH-type splicing regulatory protein 0.4
ATG14 autophagy related 14 0.4
ALDOA aldolase A, fructose-bisphosphate 0.4
CSTB cystatin B (stefin B) 0.4
CDC26 cell division cycle 26 0.4
H1-5 H1.5 linker histone, cluster member 0.4
SELENOW selenoprotein W 0.4
PPP1R2B PPP1R2 family member B 0.39
PGD phosphogluconate dehydrogenase 0.39
ZDHHC8 zinc finger, DHHC-type containing 8 0.39
EPDR1 ependymin related 1 0.39
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.39
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.38
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.38
RPS17 ribosomal protein S17 0.38
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.37
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.37
VIM vimentin 0.37
EIF4A2 eukaryotic translation initiation factor 4A2 0.37
LDHB lactate dehydrogenase B 0.36
CAPN6 calpain 6 0.36
RPL7A ribosomal protein L7a 0.36
H3C1 H3 clustered histone 1 0.36
RPL13A ribosomal protein L13a 0.36
HMGA1 high mobility group AT-hook 1 0.35
AKAP6 A kinase (PRKA) anchor protein 6 0.35
IGF1R insulin-like growth factor 1 receptor 0.35
FAM160A1 family with sequence similarity 160, member A1 0.35
HSBP1 heat shock factor binding protein 1 0.35
HSPE1 heat shock 10kDa protein 1 0.35

low expression

Symbol Name Standardized Value
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -1.01
PARPBP PARP1 binding protein -0.7
BCOR BCL6 corepressor -0.62
ZSWIM9 zinc finger SWIM-type containing 9 -0.6
ZNF394 zinc finger protein 394 -0.6
ABHD13 abhydrolase domain containing 13 -0.58
DUOX1 dual oxidase 1 -0.58
SPIN4 spindlin family, member 4 -0.56
FAT2 FAT atypical cadherin 2 -0.56
ZCCHC24 zinc finger, CCHC domain containing 24 -0.54
GJC1 gap junction protein, gamma 1, 45kDa -0.53
TTYH3 tweety family member 3 -0.49
ZNF114 zinc finger protein 114 -0.45
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -0.45
MOSPD3 motile sperm domain containing 3 -0.45
ZNF449 zinc finger protein 449 -0.44
HOXA7 homeobox A7 -0.44
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -0.43
CCNDBP1 cyclin D-type binding-protein 1 -0.43
MDM1 Mdm1 nuclear protein homolog (mouse) -0.43
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -0.43
C6ORF141 chromosome 6 open reading frame 141 -0.43
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.42
ORC3 origin recognition complex, subunit 3 -0.42
ZBTB44 zinc finger and BTB domain containing 44 -0.42
TMEM208 transmembrane protein 208 -0.41
ZNF410 zinc finger protein 410 -0.4
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -0.39
CCDC110 coiled-coil domain containing 110 -0.38
TBX3 T-box 3 -0.38
PHF1 PHD finger protein 1 -0.37
SLC16A6 solute carrier family 16, member 6 -0.37
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -0.37
HAS3 hyaluronan synthase 3 -0.37
ZNF584 zinc finger protein 584 -0.37
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.37
UBL3 ubiquitin-like 3 -0.37
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -0.36
SP140 SP140 nuclear body protein -0.36
RAB6D RAB6D, member RAS oncogene family -0.36
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -0.36
NPHP1 nephronophthisis 1 (juvenile) -0.35
SLC45A4 solute carrier family 45, member 4 -0.35
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.35
FRMPD3 FERM and PDZ domain containing 3 -0.35
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.34
SRD5A3 steroid 5 alpha-reductase 3 -0.34
HSPA8 heat shock 70kDa protein 8 -0.34
CCAR2 cell cycle and apoptosis regulator 2 -0.33
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.33
RAP1B RAP1B, member of RAS oncogene family -0.33
ZNF341 zinc finger protein 341 -0.32
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -0.32
LTBP3 latent transforming growth factor beta binding protein 3 -0.32
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.32
CKM creatine kinase, muscle -0.32
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.32
IRAK2 interleukin-1 receptor-associated kinase 2 -0.31
EPOP elongin BC and polycomb repressive complex 2 associated protein -0.31
TPST2 tyrosylprotein sulfotransferase 2 -0.31
NKD2 naked cuticle homolog 2 (Drosophila) -0.31
DUSP5 dual specificity phosphatase 5 -0.31
IFITM3 interferon induced transmembrane protein 3 -0.3
STK17B serine/threonine kinase 17b -0.3
JUN jun proto-oncogene -0.3
USP48 ubiquitin specific peptidase 48 -0.29
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.29
NEIL1 nei endonuclease VIII-like 1 (E. coli) -0.29
NRIP1 nuclear receptor interacting protein 1 -0.29
ZNF524 zinc finger protein 524 -0.29
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.29
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -0.28
MTARC2 mitochondrial amidoxime reducing component 2 -0.28
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -0.28
PRF1 perforin 1 (pore forming protein) -0.28
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.28
ERG28 ergosterol biosynthesis 28 homolog -0.28
HFE hemochromatosis -0.28
RAD51B RAD51 paralog B -0.28
BCDIN3D BCDIN3 domain containing -0.28
DCLRE1C DNA cross-link repair 1C -0.28
MPDU1 mannose-P-dolichol utilization defect 1 -0.28
SRRD SRR1 domain containing -0.27
ANKRD13B ankyrin repeat domain 13B -0.27
NABP1 nucleic acid binding protein 1 -0.27
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -0.27
UPP1 uridine phosphorylase 1 -0.27
PLA2G15 phospholipase A2, group XV -0.26
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.26
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.26
ERICH1 glutamate-rich 1 -0.26
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -0.26
GRAMD2B GRAM domain containing 2B -0.26
FLNB filamin B, beta -0.26
SH3RF2 SH3 domain containing ring finger 2 -0.26
CD63 CD63 molecule -0.26
BMP8A bone morphogenetic protein 8a -0.25
CAMKMT calmodulin-lysine N-methyltransferase -0.25
BCLAF3 BCLAF1 and THRAP3 family member 3 -0.25
BFAR bifunctional apoptosis regulator -0.25