Ranolazine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ranolazine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.246277
ANKRD12 ankyrin repeat domain 12 0.0909239
TMEM41B transmembrane protein 41B 0.0758259
ECT2 epithelial cell transforming 2 0.051121
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0507078
ZBTB20 zinc finger and BTB domain containing 20 0.0503227
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0500559
EIF1 eukaryotic translation initiation factor 1 0.0498668
SLC38A2 solute carrier family 38, member 2 0.0496785
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0450484
NCEH1 neutral cholesterol ester hydrolase 1 0.0379313
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0341396
YEATS2 YEATS domain containing 2 0.0340617
FBXO11 F-box protein 11 0.0335715
NACA nascent polypeptide-associated complex alpha subunit 0.0320041
THOC2 THO complex 2 0.0317053
ADAM17 ADAM metallopeptidase domain 17 0.0313117
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0309917
ATL2 atlastin GTPase 2 0.0298609
ERRFI1 ERBB receptor feedback inhibitor 1 0.0293035
RPL11 ribosomal protein L11 0.0289672
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0288631
ETNK1 ethanolamine kinase 1 0.0287266
PTMS parathymosin 0.0285881
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0282967
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0280707
PUM2 pumilio RNA-binding family member 2 0.0279265
MEMO1 mediator of cell motility 1 0.0271696
MED13 mediator complex subunit 13 0.0270189
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0263066
NIPBL Nipped-B homolog (Drosophila) 0.0262379
RAP1B RAP1B, member of RAS oncogene family 0.0253424
RPL37A ribosomal protein L37a 0.0251086
KIF5B kinesin family member 5B 0.0250235
WDR43 WD repeat domain 43 0.0246702
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0244707
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0242513
ARHGAP12 Rho GTPase activating protein 12 0.0238451
LRP6 low density lipoprotein receptor-related protein 6 0.0232445
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0229829
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0229747
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.0228586
RPS21 ribosomal protein S21 0.0228508
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0227565
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0225101
C2ORF42 chromosome 2 open reading frame 42 0.0224845
CDC27 cell division cycle 27 0.022479
KLHL24 kelch-like family member 24 0.0221215
TXNRD1 thioredoxin reductase 1 0.0217753
RPL37 ribosomal protein L37 0.0217378
NEK7 NIMA-related kinase 7 0.0215948
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0215939
USP15 ubiquitin specific peptidase 15 0.0213583
AFG3L2 AFG3-like AAA ATPase 2 0.0209089
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0208474
RPL7 ribosomal protein L7 0.02082
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0207767
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0207316
RASA2 RAS p21 protein activator 2 0.0206933
SET SET nuclear proto-oncogene 0.0206419
CAND1 cullin-associated and neddylation-dissociated 1 0.0205961
CHD1 chromodomain helicase DNA binding protein 1 0.0205702
RPS23 ribosomal protein S23 0.0205443
THOC1 THO complex 1 0.0201689
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0201438
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0199996
CAMKMT calmodulin-lysine N-methyltransferase 0.0199851
TNRC6C trinucleotide repeat containing 6C 0.0197994
PNISR PNN-interacting serine/arginine-rich protein 0.019714
USP9X ubiquitin specific peptidase 9, X-linked 0.0195525
KIAA1328 KIAA1328 0.0194577
RBM27 RNA binding motif protein 27 0.0194306
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) 0.0194071
PHTF2 putative homeodomain transcription factor 2 0.0193826
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0193789
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0190393
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0189848
RPL35A ribosomal protein L35a 0.0188444
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0187326
KPNB1 karyopherin (importin) beta 1 0.0187112
BRD8 bromodomain containing 8 0.0186531
MON2 MON2 homolog (S. cerevisiae) 0.0186311
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186073
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0186002
BLTP1 bridge-like lipid transfer protein family member 1 0.0185634
ATP13A3 ATPase type 13A3 0.0184518
EPCAM epithelial cell adhesion molecule 0.0183916
RBM25 RNA binding motif protein 25 0.0183539
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0183176
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0180755
RC3H1 ring finger and CCCH-type domains 1 0.0179688
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0178012
NLN neurolysin (metallopeptidase M3 family) 0.0176668
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0176191
MARCHF6 membrane associated ring-CH-type finger 6 0.0175314
SEC62 SEC62 homolog (S. cerevisiae) 0.0174432
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.017406
RPL9 ribosomal protein L9 0.0173685
WRN Werner syndrome, RecQ helicase-like 0.0171729
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0169796

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212695
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.194475
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.155833
NLGN1 neuroligin 1 -0.135176
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.122256
ANXA1 annexin A1 -0.0896683
HMGA2 high mobility group AT-hook 2 -0.0823546
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0818911
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0774319
PCDH7 protocadherin 7 -0.0750978
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0749709
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0732509
USP34 ubiquitin specific peptidase 34 -0.0716805
VIM vimentin -0.0692475
TUBA1B tubulin, alpha 1b -0.0653989
CALR calreticulin -0.0597298
DST dystonin -0.0589122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0572344
YAP1 Yes-associated protein 1 -0.057164
PFN1 profilin 1 -0.0569631
RPS2 ribosomal protein S2 -0.0557285
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0550626
ASPH aspartate beta-hydroxylase -0.0540978
TPM3 tropomyosin 3 -0.0535926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0535758
ENO1 enolase 1, (alpha) -0.0530926
EEF2 eukaryotic translation elongation factor 2 -0.0529187
PTMA prothymosin, alpha -0.052291
VMP1 vacuole membrane protein 1 -0.0500578
FNDC3B fibronectin type III domain containing 3B -0.0466235
VDAC1 voltage-dependent anion channel 1 -0.0465797
POTEF POTE ankyrin domain family, member F -0.0461332
CCN2 cellular communication network factor 2 -0.0452487
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440534
H1-0 H1.0 linker histone -0.043563
NHSL1 NHS-like 1 -0.0427457
CANX calnexin -0.0427079
ACTG1 actin gamma 1 -0.0415971
TPI1 triosephosphate isomerase 1 -0.0406975
RAB7A RAB7A, member RAS oncogene family -0.0404182
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0398641
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0394107
IFIH1 interferon induced with helicase C domain 1 -0.0386269
TPM4 tropomyosin 4 -0.0385802
YBX1 Y box binding protein 1 -0.0382637
RIMS2 regulating synaptic membrane exocytosis 2 -0.0381368
TGM2 transglutaminase 2 -0.0381023
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0380423
CELF2 CUGBP, Elav-like family member 2 -0.0369524
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0367611
AKAP12 A kinase (PRKA) anchor protein 12 -0.0366809
AHNAK AHNAK nucleoprotein -0.0365793
TBC1D5 TBC1 domain family, member 5 -0.0364765
DEK DEK proto-oncogene -0.0362495
MAP1B microtubule-associated protein 1B -0.0361204
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0361094
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0359054
CCND1 cyclin D1 -0.0349508
FTH1 ferritin, heavy polypeptide 1 -0.0346965
HMGA1 high mobility group AT-hook 1 -0.0345724
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0344056
FTL ferritin, light polypeptide -0.0339469
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0339209
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0337507
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0336373
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0336141
EDARADD EDAR-associated death domain -0.0326219
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0324732
YBX3 Y box binding protein 3 -0.0321661
PDIA6 protein disulfide isomerase family A, member 6 -0.0321427
S100A10 S100 calcium binding protein A10 -0.0310004
EIF4B eukaryotic translation initiation factor 4B -0.0309581
P4HB prolyl 4-hydroxylase, beta polypeptide -0.030874
ZNF804A zinc finger protein 804A -0.0306886
CUX1 cut-like homeobox 1 -0.0305318
EHBP1 EH domain binding protein 1 -0.030303
XPO1 exportin 1 -0.0302538
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.030006
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0296804
AXIN2 axin 2 -0.0296171
ADIPOR2 adiponectin receptor 2 -0.0295005
RRM2 ribonucleotide reductase M2 -0.0292948
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0291261
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0291199
RASAL2 RAS protein activator like 2 -0.0290518
EGR1 early growth response 1 -0.0289837
ANXA2 annexin A2 -0.0288768
APP amyloid beta (A4) precursor protein -0.0283304
CSDE1 cold shock domain containing E1, RNA-binding -0.0281806
PEG10 paternally expressed 10 -0.028156
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0281298
ZNF207 zinc finger protein 207 -0.0279714
HSPB1 heat shock 27kDa protein 1 -0.0279579
FAT1 FAT atypical cadherin 1 -0.0278494
TPT1 tumor protein, translationally-controlled 1 -0.0277283
INTS6 integrator complex subunit 6 -0.0274982
ARL15 ADP-ribosylation factor-like 15 -0.0271929
SKIL SKI-like proto-oncogene -0.0270788
TRA2B transformer 2 beta homolog (Drosophila) -0.0269799
MACF1 microtubule-actin crosslinking factor 1 -0.0267818