Ranolazine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ranolazine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP13A3 ATPase type 13A3 0.143879
CXCL8 chemokine (C-X-C motif) ligand 8 0.134472
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.103115
TRIO trio Rho guanine nucleotide exchange factor 0.0905919
CADM1 cell adhesion molecule 1 0.0763234
FNDC3B fibronectin type III domain containing 3B 0.0697625
KMT2E lysine (K)-specific methyltransferase 2E 0.0584048
SPAG9 sperm associated antigen 9 0.056191
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0559249
HIPK2 homeodomain interacting protein kinase 2 0.0541166
PDE10A phosphodiesterase 10A 0.0539087
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0488804
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0487648
ZNF292 zinc finger protein 292 0.0456262
QKI QKI, KH domain containing, RNA binding 0.0444594
NAMPT nicotinamide phosphoribosyltransferase 0.0433813
ELL2 elongation factor, RNA polymerase II, 2 0.0422983
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0420538
POSTN periostin, osteoblast specific factor 0.0419606
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0413131
PTK2 protein tyrosine kinase 2 0.0412651
USP3 ubiquitin specific peptidase 3 0.0399619
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0397512
RNF145 ring finger protein 145 0.0393722
TFG TRK-fused gene 0.0392035
ZFAND3 zinc finger, AN1-type domain 3 0.0390968
RASA2 RAS p21 protein activator 2 0.0387315
GRB10 growth factor receptor-bound protein 10 0.0377293
BHLHE40 basic helix-loop-helix family, member e40 0.0376863
FXR1 fragile X mental retardation, autosomal homolog 1 0.0370448
ESYT2 extended synaptotagmin-like protein 2 0.0370218
SQLE squalene epoxidase 0.036752
RICTOR RPTOR independent companion of MTOR, complex 2 0.0359146
ADAM9 ADAM metallopeptidase domain 9 0.0348861
UBA6 ubiquitin-like modifier activating enzyme 6 0.0347171
SETD5 SET domain containing 5 0.0346193
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0341144
TSC22D2 TSC22 domain family, member 2 0.033369
GOLGA4 golgin A4 0.032966
EPS8 epidermal growth factor receptor pathway substrate 8 0.0324757
ADAM17 ADAM metallopeptidase domain 17 0.0324619
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0323293
SMAD3 SMAD family member 3 0.0319593
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0319428
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.031922
ARRDC3 arrestin domain containing 3 0.0312609
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0309954
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0309598
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0308547
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0304512
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0303932
FTH1 ferritin, heavy polypeptide 1 0.0302836
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0301187
UGCG UDP-glucose ceramide glucosyltransferase 0.0295816
RBM39 RNA binding motif protein 39 0.0287748
RLF rearranged L-myc fusion 0.0285826
LDHA lactate dehydrogenase A 0.0283351
TRAM1 translocation associated membrane protein 1 0.0282341
MATR3 matrin 3 0.0278281
HAS2 hyaluronan synthase 2 0.0274599
MRTFA myocardin related transcription factor A 0.0273931
DPYSL3 dihydropyrimidinase-like 3 0.0272112
FOXJ3 forkhead box J3 0.0270838
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0266409
PCBP2 poly(rC) binding protein 2 0.0266314
SOD2 superoxide dismutase 2, mitochondrial 0.026585
TNIP1 TNFAIP3 interacting protein 1 0.0259381
COPA coatomer protein complex, subunit alpha 0.0253334
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0243244
OSBPL9 oxysterol binding protein-like 9 0.024183
SNX9 sorting nexin 9 0.0240197
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0237187
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0231762
RAB8B RAB8B, member RAS oncogene family 0.0229571
INSIG2 insulin induced gene 2 0.0222557
AZIN1 antizyme inhibitor 1 0.0220687
AGFG1 ArfGAP with FG repeats 1 0.0219709
CD109 CD109 molecule 0.0219679
NUP58 nucleoporin 58 0.0215663
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.021537
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0212247
JAK1 Janus kinase 1 0.0208811
MTMR3 myotubularin related protein 3 0.0208421
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0207591
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0206887
ANKRD28 ankyrin repeat domain 28 0.0205817
PDS5B PDS5 cohesin associated factor B 0.0204332
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0201817
GRID1 glutamate receptor, ionotropic, delta 1 0.0200131
KDM1A lysine (K)-specific demethylase 1A 0.0197858
MYO1B myosin IB 0.0197684
ATG3 autophagy related 3 0.0197512
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0196551
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0194722
ZNF148 zinc finger protein 148 0.0194404
ARL8B ADP-ribosylation factor-like 8B 0.0192887
CDC73 cell division cycle 73 0.0192849
ECT2 epithelial cell transforming 2 0.0192838
ADM adrenomedullin 0.0192833
MARCHF6 membrane associated ring-CH-type finger 6 0.0189935

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.264963
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.194053
VIM vimentin -0.144797
COL1A1 collagen, type I, alpha 1 -0.127885
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120754
IGFBP3 insulin-like growth factor binding protein 3 -0.119613
NDRG1 N-myc downstream regulated 1 -0.118065
ASPH aspartate beta-hydroxylase -0.0996113
CDH13 cadherin 13 -0.0973876
EXT1 exostosin glycosyltransferase 1 -0.094323
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0932446
TPM4 tropomyosin 4 -0.0879938
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0863037
CALR calreticulin -0.0846428
TMSB10 thymosin beta 10 -0.0796163
ZBTB20 zinc finger and BTB domain containing 20 -0.0773549
ACTG1 actin gamma 1 -0.0618748
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0580519
PSD3 pleckstrin and Sec7 domain containing 3 -0.0567679
LOXL2 lysyl oxidase-like 2 -0.0548848
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0546342
RRBP1 ribosome binding protein 1 -0.0535466
EGR1 early growth response 1 -0.0528774
VCL vinculin -0.0516596
CAVIN1 caveolae associated protein 1 -0.0514232
ENO1 enolase 1, (alpha) -0.0465354
MT2A metallothionein 2A -0.0457775
CANX calnexin -0.0447867
HLA-B major histocompatibility complex, class I, B -0.0437504
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0437479
GOLGB1 golgin B1 -0.0424742
TPT1 tumor protein, translationally-controlled 1 -0.0398859
AHNAK AHNAK nucleoprotein -0.0370742
IFI6 interferon, alpha-inducible protein 6 -0.0362
VDAC1 voltage-dependent anion channel 1 -0.0358471
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0353684
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0352448
TRPS1 trichorhinophalangeal syndrome I -0.0336328
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.032726
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0324925
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0320219
NALF1 NALCN channel auxiliary factor 1 -0.0316871
RIGI RNA sensor RIG-I -0.0314702
HDLBP high density lipoprotein binding protein -0.0311472
FTL ferritin, light polypeptide -0.0309782
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0302187
COL5A1 collagen, type V, alpha 1 -0.0298279
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0295138
RPS19 ribosomal protein S19 -0.0292856
COL3A1 collagen, type III, alpha 1 -0.0287774
GLIS3 GLIS family zinc finger 3 -0.0286377
MTDH metadherin -0.0286338
RPLP2 ribosomal protein, large, P2 -0.0284071
ZBTB38 zinc finger and BTB domain containing 38 -0.0281368
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0277859
COL6A3 collagen, type VI, alpha 3 -0.027694
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0275004
SP100 SP100 nuclear antigen -0.0274578
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0273002
IER3 immediate early response 3 -0.0270494
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0266127
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0265128
ATXN1 ataxin 1 -0.0264426
OSMR oncostatin M receptor -0.0264291
CALU calumenin -0.026331
CUX1 cut-like homeobox 1 -0.026072
COL1A2 collagen, type I, alpha 2 -0.0260593
FBXL7 F-box and leucine-rich repeat protein 7 -0.0259047
IL6 interleukin 6 -0.0255687
PALLD palladin, cytoskeletal associated protein -0.0254178
MACF1 microtubule-actin crosslinking factor 1 -0.025296
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0245966
PLEC plectin -0.0243527
COL6A2 collagen, type VI, alpha 2 -0.0241761
MAP4 microtubule-associated protein 4 -0.0241473
TGFBI transforming growth factor, beta-induced, 68kDa -0.0240432
TPM1 tropomyosin 1 (alpha) -0.0237371
SPDYA speedy/RINGO cell cycle regulator family member A -0.0236104
HM13 histocompatibility (minor) 13 -0.0234852
RPS8 ribosomal protein S8 -0.0231278
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0230846
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.023027
RPS3 ribosomal protein S3 -0.0229832
SMYD3 SET and MYND domain containing 3 -0.0228936
PTMA prothymosin, alpha -0.0226644
NAV1 neuron navigator 1 -0.0226267
IFI16 interferon, gamma-inducible protein 16 -0.022348
RPL31 ribosomal protein L31 -0.0222249
MBD5 methyl-CpG binding domain protein 5 -0.0221539
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0221311
RPL26 ribosomal protein L26 -0.0220116
STC1 stanniocalcin 1 -0.0218934
PTPRF protein tyrosine phosphatase, receptor type, F -0.0217734
SAMD9 sterile alpha motif domain containing 9 -0.0214199
RPS24 ribosomal protein S24 -0.0213904
EGFR epidermal growth factor receptor -0.0211798
RPS11 ribosomal protein S11 -0.021036
PTPRG protein tyrosine phosphatase, receptor type, G -0.020617
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0206125
RPLP1 ribosomal protein, large, P1 -0.0205348