| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ranolazine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ranolazine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.195523 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.105518 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0491034 |
| DTNA | dystrobrevin, alpha | 0.0375822 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0374365 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0353763 |
| HMGA1 | high mobility group AT-hook 1 | 0.0337174 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0319239 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0311085 |
| FMNL2 | formin-like 2 | 0.0307802 |
| OLA1 | Obg-like ATPase 1 | 0.0305528 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0305192 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0291805 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0291095 |
| INSIG2 | insulin induced gene 2 | 0.0281737 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.027988 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.026802 |
| ATP13A3 | ATPase type 13A3 | 0.0242534 |
| PCGF5 | polycomb group ring finger 5 | 0.0239064 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0230335 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0228641 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0222332 |
| RPS6 | ribosomal protein S6 | 0.0220907 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0218827 |
| RPL11 | ribosomal protein L11 | 0.0215761 |
| PLIN2 | perilipin 2 | 0.0215404 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0209998 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0208818 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0207558 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0205931 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0203671 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.020303 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0198945 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0198464 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0195298 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0191632 |
| FOXJ3 | forkhead box J3 | 0.0191254 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0186293 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.018518 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0182501 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0182451 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0182025 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0179792 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0178477 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.017578 |
| RPL23 | ribosomal protein L23 | 0.0175395 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.017361 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0172027 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0170471 |
| KIF1B | kinesin family member 1B | 0.0169541 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.016748 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0162287 |
| NGLY1 | N-glycanase 1 | 0.0161405 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0161163 |
| RNF145 | ring finger protein 145 | 0.0159644 |
| QKI | QKI, KH domain containing, RNA binding | 0.0158939 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0158505 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0154272 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0154057 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0153925 |
| RPL7 | ribosomal protein L7 | 0.0153039 |
| ITGAV | integrin, alpha V | 0.0152991 |
| FOXO1 | forkhead box O1 | 0.0152598 |
| RPL37A | ribosomal protein L37a | 0.0151238 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0149142 |
| SEC24B | SEC24 family member B | 0.0149078 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0148499 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.014814 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0147794 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0147307 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0146635 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0146325 |
| SETD5 | SET domain containing 5 | 0.0146236 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0144635 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0144059 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0143866 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0143506 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0142188 |
| ZNF451 | zinc finger protein 451 | 0.014158 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0141536 |
| RPS27 | ribosomal protein S27 | 0.0138774 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0138556 |
| MTMR3 | myotubularin related protein 3 | 0.0138537 |
| MCU | mitochondrial calcium uniporter | 0.0138255 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0136992 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0136441 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0136161 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0135563 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0135514 |
| WDR43 | WD repeat domain 43 | 0.0134957 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0134574 |
| MYO1B | myosin IB | 0.0134545 |
| RREB1 | ras responsive element binding protein 1 | 0.0134094 |
| MYO6 | myosin VI | 0.0133435 |
| NBAS | neuroblastoma amplified sequence | 0.0132339 |
| RPL27 | ribosomal protein L27 | 0.0131605 |
| SMAD5 | SMAD family member 5 | 0.0131446 |
| MT2A | metallothionein 2A | 0.013022 |
| CDC42 | cell division cycle 42 | 0.0128384 |
| CCNY | cyclin Y | 0.0128209 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.311603 |
| FN1 | fibronectin 1 | -0.238129 |
| C3 | complement component 3 | -0.184452 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.16799 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.148309 |
| GPC3 | glypican 3 | -0.125584 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0925902 |
| PEG3 | paternally expressed 3 | -0.0857871 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0853454 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.083991 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0818614 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0749557 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0741546 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0733422 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0725827 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0663041 |
| A2M | alpha-2-macroglobulin | -0.0651197 |
| EHBP1 | EH domain binding protein 1 | -0.0610106 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0598494 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0578712 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0545289 |
| DSPP | dentin sialophosphoprotein | -0.0537688 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0537604 |
| RRBP1 | ribosome binding protein 1 | -0.0537584 |
| TRIM26 | tripartite motif containing 26 | -0.0468884 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0465884 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0445427 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0430878 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0429623 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0424914 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0416119 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0406006 |
| ENO1 | enolase 1, (alpha) | -0.039366 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.039217 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0379052 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0371085 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0371056 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0369825 |
| CFB | complement factor B | -0.0369017 |
| ACTN4 | actinin, alpha 4 | -0.0367472 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0366537 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0363587 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0362012 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0360895 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0359689 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0350182 |
| GPC6 | glypican 6 | -0.0342808 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.033365 |
| RNF213 | ring finger protein 213 | -0.0330097 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0320547 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0316621 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0315037 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0306371 |
| OSMR | oncostatin M receptor | -0.0304805 |
| TF | transferrin | -0.0302237 |
| LOC112694756 | uncharaterized LOC112694756 | -0.028915 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0288561 |
| SVIL | supervillin | -0.0287597 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.02852 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.028383 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0283678 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0280613 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0279794 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0277492 |
| KIAA1217 | KIAA1217 | -0.0277032 |
| KRT8 | keratin 8, type II | -0.0271523 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0269786 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0264894 |
| TBCK | TBC1 domain containing kinase | -0.0263877 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0261727 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0261441 |
| DOCK4 | dedicator of cytokinesis 4 | -0.025959 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0251242 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0247671 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0240792 |
| LCN2 | lipocalin 2 | -0.0240341 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0240161 |
| TMEM181 | transmembrane protein 181 | -0.0239882 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0239008 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0238634 |
| FTL | ferritin, light polypeptide | -0.0237872 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0236171 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0234218 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0233609 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.023282 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0232227 |
| EGR1 | early growth response 1 | -0.0232116 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0231944 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0231747 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0231241 |
| PEG10 | paternally expressed 10 | -0.0230427 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0225195 |
| SYN3 | synapsin III | -0.0223959 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0222328 |
| IER3 | immediate early response 3 | -0.0220539 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0219611 |
| DOK6 | docking protein 6 | -0.021831 |
| HLF | hepatic leukemia factor | -0.0217739 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0217135 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0216565 |
