| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ranolazine perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ranolazine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.116416 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.105399 |
| RPS6 | ribosomal protein S6 | 0.0931191 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0897278 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0884565 |
| RNF145 | ring finger protein 145 | 0.0634897 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.060246 |
| EREG | epiregulin | 0.0572662 |
| GOLGA4 | golgin A4 | 0.0567138 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0564875 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0522124 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0438412 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0437728 |
| PKM | pyruvate kinase, muscle | 0.0432628 |
| ABHD2 | abhydrolase domain containing 2 | 0.042711 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0417679 |
| RPLP0 | ribosomal protein, large, P0 | 0.0403234 |
| RPS19 | ribosomal protein S19 | 0.038803 |
| FTL | ferritin, light polypeptide | 0.0386669 |
| RPLP1 | ribosomal protein, large, P1 | 0.0384737 |
| S100A6 | S100 calcium binding protein A6 | 0.0376327 |
| SETD5 | SET domain containing 5 | 0.0371047 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0368758 |
| S100P | S100 calcium binding protein P | 0.0366795 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0358523 |
| PCBP2 | poly(rC) binding protein 2 | 0.0357196 |
| SRP54 | signal recognition particle 54kDa | 0.035214 |
| MT2A | metallothionein 2A | 0.0347323 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.0319577 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.030503 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0304446 |
| ITGA6 | integrin, alpha 6 | 0.0302453 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0298374 |
| EXOC1 | exocyst complex component 1 | 0.0297799 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0296091 |
| RPL11 | ribosomal protein L11 | 0.029397 |
| RPLP2 | ribosomal protein, large, P2 | 0.0292795 |
| YTHDC1 | YTH domain containing 1 | 0.0292498 |
| PLS1 | plastin 1 | 0.0291841 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0286533 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0285831 |
| RPL12 | ribosomal protein L12 | 0.0285367 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0282303 |
| PTEN | phosphatase and tensin homolog | 0.0280604 |
| RPS12 | ribosomal protein S12 | 0.0278971 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0275851 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0273775 |
| RPL31 | ribosomal protein L31 | 0.0269359 |
| RPL7 | ribosomal protein L7 | 0.0259431 |
| RNF43 | ring finger protein 43 | 0.0258518 |
| FOXO1 | forkhead box O1 | 0.0257086 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0255122 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0251654 |
| FAM13A | family with sequence similarity 13, member A | 0.0251004 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0250636 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0250002 |
| RPS13 | ribosomal protein S13 | 0.0249145 |
| ATP11B | ATPase, class VI, type 11B | 0.0247951 |
| GDF15 | growth differentiation factor 15 | 0.0247234 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0247048 |
| RPS8 | ribosomal protein S8 | 0.0243271 |
| RPS27 | ribosomal protein S27 | 0.023654 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0236054 |
| RPS25 | ribosomal protein S25 | 0.0235894 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0235567 |
| RAB10 | RAB10, member RAS oncogene family | 0.0234615 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0234238 |
| THOC2 | THO complex 2 | 0.0233325 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0232827 |
| RPS14 | ribosomal protein S14 | 0.0228472 |
| RPS20 | ribosomal protein S20 | 0.0225988 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0224512 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0224109 |
| RPS23 | ribosomal protein S23 | 0.0223015 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0221834 |
| MT1E | metallothionein 1E | 0.0220468 |
| NUP58 | nucleoporin 58 | 0.0219713 |
| TMEM87A | transmembrane protein 87A | 0.0215566 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.0215496 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0213997 |
| TXNIP | thioredoxin interacting protein | 0.0209787 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0209638 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0205495 |
| EFHD2 | EF-hand domain family, member D2 | 0.0203542 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.0203363 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0199391 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0196771 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0195059 |
| RPL23 | ribosomal protein L23 | 0.0194925 |
| TPR | translocated promoter region, nuclear basket protein | 0.019423 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.019411 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0193459 |
| RPL39 | ribosomal protein L39 | 0.0193391 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0192683 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0190967 |
| RPL29 | ribosomal protein L29 | 0.0189865 |
| EPCAM | epithelial cell adhesion molecule | 0.0189251 |
| TMF1 | TATA element modulatory factor 1 | 0.0189249 |
| RPS5 | ribosomal protein S5 | 0.0186974 |
| IGFL2 | IGF-like family member 2 | 0.018539 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.24212 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.162476 |
| NPSR1 | neuropeptide S receptor 1 | -0.157373 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.120436 |
| EZR | ezrin | -0.108075 |
| PTMA | prothymosin, alpha | -0.0950796 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0939119 |
| VCL | vinculin | -0.0854462 |
| AHNAK | AHNAK nucleoprotein | -0.0834886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0817283 |
| ACTN4 | actinin, alpha 4 | -0.0796458 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0772143 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0768357 |
| TPM4 | tropomyosin 4 | -0.0735227 |
| PIGR | polymeric immunoglobulin receptor | -0.0695259 |
| GPHN | gephyrin | -0.0690388 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0624693 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0602864 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0572694 |
| FHIT | fragile histidine triad | -0.057163 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0551401 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0545601 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0539297 |
| CALR | calreticulin | -0.052179 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0517265 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0499593 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0484113 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0478426 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0471698 |
| CTBP2 | C-terminal binding protein 2 | -0.0461329 |
| H1-0 | H1.0 linker histone | -0.0457273 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.045153 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0440914 |
| TFRC | transferrin receptor | -0.0432859 |
| LAMA4 | laminin, alpha 4 | -0.043109 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0429342 |
| FAT1 | FAT atypical cadherin 1 | -0.0427868 |
| ANXA1 | annexin A1 | -0.0427366 |
| KRT8 | keratin 8, type II | -0.0420342 |
| EMP1 | epithelial membrane protein 1 | -0.041921 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0416732 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0404556 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0402319 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0394986 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0383519 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0383424 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0383407 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0377825 |
| NRXN3 | neurexin 3 | -0.0377119 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0375396 |
| APP | amyloid beta (A4) precursor protein | -0.0370414 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0365617 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0360259 |
| DENND1A | DENN/MADD domain containing 1A | -0.0359911 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0359625 |
| RRBP1 | ribosome binding protein 1 | -0.0359576 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0359301 |
| CANX | calnexin | -0.035861 |
| MECOM | MDS1 and EVI1 complex locus | -0.0349767 |
| MYO5B | myosin VB | -0.0338684 |
| FRMD5 | FERM domain containing 5 | -0.0334933 |
| TCF12 | transcription factor 12 | -0.0327793 |
| RPS2 | ribosomal protein S2 | -0.0325938 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0324095 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0319654 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0318858 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0317068 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0315243 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0314369 |
| NDRG1 | N-myc downstream regulated 1 | -0.0307733 |
| RNF217 | ring finger protein 217 | -0.0305226 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0305059 |
| HMGB1 | high mobility group box 1 | -0.0304328 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0301976 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0301254 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0297769 |
| LMNA | lamin A/C | -0.0296852 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.02916 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0288573 |
| FHL2 | four and a half LIM domains 2 | -0.028533 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0278912 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0277551 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0274982 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0274413 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.027269 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0272034 |
| ANXA11 | annexin A11 | -0.0270835 |
| CCND1 | cyclin D1 | -0.0269184 |
| JUN | jun proto-oncogene | -0.0268758 |
| FOXP1 | forkhead box P1 | -0.0268432 |
| AGR2 | anterior gradient 2 | -0.0264343 |
| TUFT1 | tuftelin 1 | -0.0263535 |
| PRELID2 | PRELI domain containing 2 | -0.0263136 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0259532 |
| ABR | active BCR-related | -0.025875 |
| WDR1 | WD repeat domain 1 | -0.025565 |
| SMYD3 | SET and MYND domain containing 3 | -0.025473 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -0.0252454 |
| TMSB10 | thymosin beta 10 | -0.0251466 |
| MTAP | methylthioadenosine phosphorylase | -0.0250562 |
