Ranolazine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ranolazine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.10746
EIF1 eukaryotic translation initiation factor 1 0.0921491
TMSB10 thymosin beta 10 0.0891902
MT2A metallothionein 2A 0.086249
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0791203
TM4SF1 transmembrane 4 L six family member 1 0.0756114
TMEM41B transmembrane protein 41B 0.0647348
ERRFI1 ERBB receptor feedback inhibitor 1 0.0645856
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0542136
WWTR1 WW domain containing transcription regulator 1 0.0527197
RAI1 retinoic acid induced 1 0.0510107
MT1X metallothionein 1X 0.050636
KMT2E lysine (K)-specific methyltransferase 2E 0.0433941
SPAG9 sperm associated antigen 9 0.0430262
BZW1 basic leucine zipper and W2 domains 1 0.0410229
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0401697
CXCL8 chemokine (C-X-C motif) ligand 8 0.0395261
RPL23 ribosomal protein L23 0.0375928
UPP1 uridine phosphorylase 1 0.0364358
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0361375
RPS8 ribosomal protein S8 0.0346677
SDK1 sidekick cell adhesion molecule 1 0.033249
ESYT2 extended synaptotagmin-like protein 2 0.0325626
PGK1 phosphoglycerate kinase 1 0.0323051
RPL37A ribosomal protein L37a 0.0315158
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0308671
RPL35A ribosomal protein L35a 0.0304686
FLNB filamin B, beta 0.0299959
RPS19 ribosomal protein S19 0.0282883
ADARB1 adenosine deaminase, RNA-specific, B1 0.0279841
MT1E metallothionein 1E 0.0279346
CAPRIN2 caprin family member 2 0.0278525
ZEB1 zinc finger E-box binding homeobox 1 0.0276344
SEC24A SEC24 family member A 0.0274735
USP12 ubiquitin specific peptidase 12 0.0258877
MARCHF6 membrane associated ring-CH-type finger 6 0.0256647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0253489
ATP13A3 ATPase type 13A3 0.0253411
PYGL phosphorylase, glycogen, liver 0.025306
EMP1 epithelial membrane protein 1 0.0248962
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0248137
GARS1 glycyl-tRNA synthetase 1 0.0246978
AREG amphiregulin 0.0245297
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0241025
USP36 ubiquitin specific peptidase 36 0.0237117
PNISR PNN-interacting serine/arginine-rich protein 0.0236951
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0236909
ANKRD12 ankyrin repeat domain 12 0.0235715
DPYSL2 dihydropyrimidinase-like 2 0.022926
TTC3 tetratricopeptide repeat domain 3 0.0228122
SNX14 sorting nexin 14 0.0225814
GPATCH2L G patch domain containing 2-like 0.0222869
USP9X ubiquitin specific peptidase 9, X-linked 0.0221178
RASA2 RAS p21 protein activator 2 0.0220237
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0218757
LRRC49 leucine rich repeat containing 49 0.0218224
FMNL2 formin-like 2 0.0217755
LOXL2 lysyl oxidase-like 2 0.0212396
ARF6 ADP-ribosylation factor 6 0.0211582
CSNK1A1 casein kinase 1, alpha 1 0.0210633
RAP2B RAP2B, member of RAS oncogene family 0.0210136
NGLY1 N-glycanase 1 0.0206859
AGTPBP1 ATP/GTP binding protein 1 0.0203899
RB1CC1 RB1-inducible coiled-coil 1 0.0196835
MIS18BP1 MIS18 binding protein 1 0.0196545
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0196446
JMJD1C jumonji domain containing 1C 0.0196026
BARX2 BARX homeobox 2 0.0195636
RPS21 ribosomal protein S21 0.0193898
SLC38A2 solute carrier family 38, member 2 0.019239
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0187625
KDM3A lysine (K)-specific demethylase 3A 0.0187346
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186747
RPL11 ribosomal protein L11 0.0186551
S100A6 S100 calcium binding protein A6 0.0185895
PRDX1 peroxiredoxin 1 0.0185484
RPS27 ribosomal protein S27 0.0185116
RAB10 RAB10, member RAS oncogene family 0.0183152
ANKRD36 ankyrin repeat domain 36 0.0180584
RPL38 ribosomal protein L38 0.0180357
SLC38A1 solute carrier family 38, member 1 0.0178126
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0175677
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0175437
GOLT1B golgi transport 1B 0.0173531
WRN Werner syndrome, RecQ helicase-like 0.0172633
RUNX1 runt-related transcription factor 1 0.0170905
NAMPT nicotinamide phosphoribosyltransferase 0.0170377
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0166161
PUM2 pumilio RNA-binding family member 2 0.0165413
ARRDC3 arrestin domain containing 3 0.0165395
CAPN2 calpain 2, (m/II) large subunit 0.0165302
POM121C POM121 transmembrane nucleoporin C 0.0164567
RPL36 ribosomal protein L36 0.0162653
HBEGF heparin-binding EGF-like growth factor 0.0162468
ANGPTL4 angiopoietin-like 4 0.0162409
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0161857
GAN gigaxonin 0.0161725
HOOK2 hook microtubule-tethering protein 2 0.0161076
NPC1 Niemann-Pick disease, type C1 0.0160784
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.016053

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.14976
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.143158
VIM vimentin -0.129483
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.124819
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.102405
CD44 CD44 molecule (Indian blood group) -0.0941769
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0910282
PSD3 pleckstrin and Sec7 domain containing 3 -0.0777764
TXNIP thioredoxin interacting protein -0.0739325
CADM2 cell adhesion molecule 2 -0.073223
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0730408
POTEF POTE ankyrin domain family, member F -0.0716376
DPYD dihydropyrimidine dehydrogenase -0.0670776
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0656047
TP63 tumor protein p63 -0.0644691
EEF2 eukaryotic translation elongation factor 2 -0.0635388
YBX1 Y box binding protein 1 -0.0599399
ADGRG6 adhesion G protein-coupled receptor G6 -0.0587631
ENO1 enolase 1, (alpha) -0.0587532
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0585011
RNF213 ring finger protein 213 -0.0584184
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0583623
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0570568
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0562947
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0560473
DLG1 discs, large homolog 1 (Drosophila) -0.0549056
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0539739
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0535417
ADAR adenosine deaminase, RNA-specific -0.0522611
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0511045
APP amyloid beta (A4) precursor protein -0.0487873
RIGI RNA sensor RIG-I -0.0485947
SP100 SP100 nuclear antigen -0.0485298
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0484032
EXOC4 exocyst complex component 4 -0.0480152
XPO1 exportin 1 -0.0479565
GCLM glutamate-cysteine ligase, modifier subunit -0.0477436
CFAP299 cilia and flagella associated protein 299 -0.0472553
PTPRF protein tyrosine phosphatase, receptor type, F -0.0467437
FTH1 ferritin, heavy polypeptide 1 -0.0465741
IFIH1 interferon induced with helicase C domain 1 -0.0459355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0455982
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0454064
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0429565
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0416434
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0415285
PTMA prothymosin, alpha -0.0408787
ZNF217 zinc finger protein 217 -0.0406555
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0403083
CALR calreticulin -0.0400016
PLK2 polo-like kinase 2 -0.0399429
COL5A2 collagen, type V, alpha 2 -0.0391577
IFI6 interferon, alpha-inducible protein 6 -0.0390874
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0390861
CDK6 cyclin-dependent kinase 6 -0.0387552
TSC22D1 TSC22 domain family, member 1 -0.0384342
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.037837
CSDE1 cold shock domain containing E1, RNA-binding -0.0372715
CENPF centromere protein F, 350/400kDa -0.0370426
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0369898
EHBP1 EH domain binding protein 1 -0.0368918
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0366558
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0363264
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0359809
ATF7IP activating transcription factor 7 interacting protein -0.0356316
TAPBP TAP binding protein (tapasin) -0.0353657
WARS1 tryptophanyl-tRNA synthetase 1 -0.0349858
KMT2A lysine (K)-specific methyltransferase 2A -0.0343435
HMGA1 high mobility group AT-hook 1 -0.0339034
PODXL podocalyxin-like -0.0336025
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0335408
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0335054
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.032278
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0321452
MAP4 microtubule-associated protein 4 -0.0316085
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.031063
SMC4 structural maintenance of chromosomes 4 -0.0308634
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.030711
PFN1 profilin 1 -0.0305249
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0299935
DEK DEK proto-oncogene -0.0294756
H1-0 H1.0 linker histone -0.0294004
ECE1 endothelin converting enzyme 1 -0.0293668
FAM120A family with sequence similarity 120A -0.0293567
EFNA5 ephrin-A5 -0.0289217
TPI1 triosephosphate isomerase 1 -0.0287679
TPM3 tropomyosin 3 -0.0287369
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0281906
SMYD3 SET and MYND domain containing 3 -0.0281482
IFITM1 interferon induced transmembrane protein 1 -0.0281433
B2M beta-2-microglobulin -0.0280773
SDC4 syndecan 4 -0.0279281
TTC28 tetratricopeptide repeat domain 28 -0.027753
HLA-B major histocompatibility complex, class I, B -0.027618
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.027459
CANX calnexin -0.0272722
ASPH aspartate beta-hydroxylase -0.0271576
VDAC1 voltage-dependent anion channel 1 -0.0271211
SYT1 synaptotagmin I -0.0269637
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0267688