| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ranolazine perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ranolazine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.147956 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.134867 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.106917 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0887459 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0812772 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0804149 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.078227 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0719903 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0617812 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0606396 |
| PCBP2 | poly(rC) binding protein 2 | 0.0580642 |
| NRP1 | neuropilin 1 | 0.0578757 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0530725 |
| ATP13A3 | ATPase type 13A3 | 0.0515747 |
| EFNA5 | ephrin-A5 | 0.0514215 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0504535 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0497344 |
| MEF2A | myocyte enhancer factor 2A | 0.0496379 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0487527 |
| SIK3 | SIK family kinase 3 | 0.0487022 |
| ITGAV | integrin, alpha V | 0.048433 |
| MTSS1 | metastasis suppressor 1 | 0.0458622 |
| FAM13A | family with sequence similarity 13, member A | 0.0449642 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0447136 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0441533 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0437343 |
| NGLY1 | N-glycanase 1 | 0.043219 |
| RUNX2 | runt-related transcription factor 2 | 0.0426448 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0421353 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0418385 |
| HAS2 | hyaluronan synthase 2 | 0.0415036 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0403694 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0373374 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0372969 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0372902 |
| CDH13 | cadherin 13 | 0.0370955 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0364405 |
| RNF145 | ring finger protein 145 | 0.0361234 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0359168 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0334787 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0331741 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0327044 |
| ADD3 | adducin 3 (gamma) | 0.0325178 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0323008 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0315048 |
| RPS6 | ribosomal protein S6 | 0.0311155 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0308836 |
| RPS12 | ribosomal protein S12 | 0.0308656 |
| SETD5 | SET domain containing 5 | 0.0306544 |
| NAV2 | neuron navigator 2 | 0.03041 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0302554 |
| PTK2 | protein tyrosine kinase 2 | 0.029188 |
| PRELID2 | PRELI domain containing 2 | 0.0291778 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.029101 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0290728 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0288943 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.028347 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0275052 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0272436 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0270743 |
| VEGFA | vascular endothelial growth factor A | 0.026943 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0269229 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.0265911 |
| IL6ST | interleukin 6 signal transducer | 0.0265632 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0262676 |
| ZNF292 | zinc finger protein 292 | 0.025928 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0257757 |
| ZNF638 | zinc finger protein 638 | 0.0254416 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0252925 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0252844 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0249321 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0248537 |
| HELZ | helicase with zinc finger | 0.0244037 |
| FMNL2 | formin-like 2 | 0.0242032 |
| JMJD1C | jumonji domain containing 1C | 0.024138 |
| SECISBP2L | SECIS binding protein 2-like | 0.0240316 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.023947 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0238251 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0236816 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0235106 |
| YEATS2 | YEATS domain containing 2 | 0.0233354 |
| OXR1 | oxidation resistance 1 | 0.0232117 |
| DUSP5 | dual specificity phosphatase 5 | 0.023136 |
| GOLGA4 | golgin A4 | 0.02302 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0228971 |
| B2M | beta-2-microglobulin | 0.0228792 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0226957 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0226907 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0226146 |
| TMEM165 | transmembrane protein 165 | 0.0225847 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0225321 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0224354 |
| ATP11B | ATPase, class VI, type 11B | 0.022386 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0222491 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0221396 |
| PRRC2C | proline-rich coiled-coil 2C | 0.022139 |
| CDCP1 | CUB domain containing protein 1 | 0.0219201 |
| RAI14 | retinoic acid induced 14 | 0.0218455 |
| DTNA | dystrobrevin, alpha | 0.0216945 |
| ANGPTL4 | angiopoietin-like 4 | 0.0216811 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.13807 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0914414 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0802937 |
| OSMR | oncostatin M receptor | -0.0724853 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0724067 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0719924 |
| NTN4 | netrin 4 | -0.061809 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0603569 |
| RBM39 | RNA binding motif protein 39 | -0.0585989 |
| LOX | lysyl oxidase | -0.0572476 |
| EGR1 | early growth response 1 | -0.0567152 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0562157 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0553974 |
| VCL | vinculin | -0.0552286 |
| FAM20C | family with sequence similarity 20, member C | -0.0540828 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0533839 |
| FN1 | fibronectin 1 | -0.0514538 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0508938 |
| TNNC1 | troponin C type 1 (slow) | -0.0506442 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0468693 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0418782 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0415656 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0397263 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.038858 |
| IER3 | immediate early response 3 | -0.0387483 |
| RAD51B | RAD51 paralog B | -0.0382408 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0368824 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0362813 |
| GLCCI1 | glucocorticoid induced 1 | -0.0354314 |
| ARF4 | ADP-ribosylation factor 4 | -0.0347883 |
| EZR | ezrin | -0.0344659 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0344468 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0335972 |
| IL1R1 | interleukin 1 receptor, type I | -0.0328067 |
| JUN | jun proto-oncogene | -0.031913 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0316125 |
| EHBP1 | EH domain binding protein 1 | -0.0314632 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0305375 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0303132 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0299905 |
| HDLBP | high density lipoprotein binding protein | -0.0297369 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0288241 |
| ZNF804A | zinc finger protein 804A | -0.0284238 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0283952 |
| GOLGA3 | golgin A3 | -0.0281483 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0281168 |
| MYO10 | myosin X | -0.0280868 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0277204 |
| RNF24 | ring finger protein 24 | -0.0271781 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0271766 |
| EXOC4 | exocyst complex component 4 | -0.0270958 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0269279 |
| AADAC | arylacetamide deacetylase | -0.026901 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.026567 |
| YBX3 | Y box binding protein 3 | -0.0264637 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0262871 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0262323 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0259764 |
| AOPEP | aminopeptidase O (putative) | -0.025595 |
| MORF4L2 | mortality factor 4 like 2 | -0.0254512 |
| YME1L1 | YME1-like 1 ATPase | -0.0253859 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0252796 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0247618 |
| SP100 | SP100 nuclear antigen | -0.0245456 |
| MAP1B | microtubule-associated protein 1B | -0.0245109 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0244677 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0242561 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0239465 |
| HM13 | histocompatibility (minor) 13 | -0.0237496 |
| CANX | calnexin | -0.0235852 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0235178 |
| ASPH | aspartate beta-hydroxylase | -0.0233887 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0233832 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0231589 |
| GPC6 | glypican 6 | -0.0228191 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0225799 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.02257 |
| CALU | calumenin | -0.0224566 |
| AHNAK | AHNAK nucleoprotein | -0.0222443 |
| NABP1 | nucleic acid binding protein 1 | -0.0218245 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0217804 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0212918 |
| TXLNG | taxilin gamma | -0.0209059 |
| H1-0 | H1.0 linker histone | -0.0207244 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0206611 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0204011 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.020367 |
| HBP1 | HMG-box transcription factor 1 | -0.0202795 |
| BPTF | bromodomain PHD finger transcription factor | -0.0201644 |
| ATM | ATM serine/threonine kinase | -0.0199942 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0198283 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0196806 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0196391 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0196313 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -0.0195419 |
| SQSTM1 | sequestosome 1 | -0.0194838 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0194735 |
| KYNU | kynureninase | -0.0194375 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0193837 |
| AVIL | advillin | -0.0189155 |
