Ranolazine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ranolazine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.157889
TXNRD1 thioredoxin reductase 1 0.154207
GRAMD1B GRAM domain containing 1B 0.150934
FTL ferritin, light polypeptide 0.122362
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114138
IGF2 insulin-like growth factor 2 0.105949
FGB fibrinogen beta chain 0.0809459
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0795147
PM20D1 peptidase M20 domain containing 1 0.0756236
RTN4 reticulon 4 0.0721588
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0703
WDR43 WD repeat domain 43 0.0700229
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0662679
RBM39 RNA binding motif protein 39 0.0630536
SLC38A2 solute carrier family 38, member 2 0.0616653
RBM25 RNA binding motif protein 25 0.0562506
ZNF292 zinc finger protein 292 0.0531923
TPD52 tumor protein D52 0.051726
ECT2 epithelial cell transforming 2 0.0503875
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0503256
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0501493
TFPI2 tissue factor pathway inhibitor 2 0.0495377
NUP58 nucleoporin 58 0.0488369
NAMPT nicotinamide phosphoribosyltransferase 0.0487028
PCBP2 poly(rC) binding protein 2 0.0484174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0482338
CCNL1 cyclin L1 0.0475729
USP3 ubiquitin specific peptidase 3 0.0445559
CYRIB CYFIP related Rac1 interactor B 0.0433922
PUM1 pumilio RNA-binding family member 1 0.0429287
CHN1 chimerin 1 0.0424138
VEZT vezatin, adherens junctions transmembrane protein 0.042229
YBX3 Y box binding protein 3 0.0417564
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402084
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0390638
ADAM9 ADAM metallopeptidase domain 9 0.0382567
NCEH1 neutral cholesterol ester hydrolase 1 0.0378052
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0376482
NOP58 NOP58 ribonucleoprotein 0.0375049
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0374064
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.037052
HDAC9 histone deacetylase 9 0.0369234
QKI QKI, KH domain containing, RNA binding 0.0368519
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0367492
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0361413
MARCHF6 membrane associated ring-CH-type finger 6 0.0357598
PFDN2 prefoldin subunit 2 0.035342
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0351786
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0347361
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0343769
KLF6 Kruppel-like factor 6 0.0341889
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0340761
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0332418
EIF4A1 eukaryotic translation initiation factor 4A1 0.0332224
MATR3 matrin 3 0.0323464
SIK3 SIK family kinase 3 0.0323463
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0322481
RNF145 ring finger protein 145 0.0322309
SLC38A1 solute carrier family 38, member 1 0.0321508
MIS18BP1 MIS18 binding protein 1 0.03186
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0318499
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0318138
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0316676
NEK7 NIMA-related kinase 7 0.0313464
ENAH enabled homolog (Drosophila) 0.0312771
YME1L1 YME1-like 1 ATPase 0.0312723
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0310022
KMT2E lysine (K)-specific methyltransferase 2E 0.0307877
BCLAF1 BCL2-associated transcription factor 1 0.0305732
ARL5B ADP-ribosylation factor-like 5B 0.0305411
ANKRD28 ankyrin repeat domain 28 0.0305236
MTF2 metal response element binding transcription factor 2 0.0303856
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0303042
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0301614
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0300476
OSBPL9 oxysterol binding protein-like 9 0.0295893
PAWR PRKC, apoptosis, WT1, regulator 0.0295615
NOL10 nucleolar protein 10 0.0292999
WBP11 WW domain binding protein 11 0.0291799
RLF rearranged L-myc fusion 0.0289213
FGG fibrinogen gamma chain 0.0289188
MCL1 myeloid cell leukemia 1 0.0287765
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0283729
CRY1 cryptochrome circadian clock 1 0.0281067
RHEB Ras homolog enriched in brain 0.0276206
MTMR3 myotubularin related protein 3 0.0275923
BHLHE40 basic helix-loop-helix family, member e40 0.0272719
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0272223
BZW2 basic leucine zipper and W2 domains 2 0.0270889
NUP153 nucleoporin 153kDa 0.0270345
TRA2B transformer 2 beta homolog (Drosophila) 0.0270147
RAD21 RAD21 homolog (S. pombe) 0.0264811
PA2G4 proliferation-associated 2G4, 38kDa 0.0264679
TMEM87A transmembrane protein 87A 0.0264248
HBS1L HBS1-like translational GTPase 0.0260398
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0257629
DGKD diacylglycerol kinase, delta 130kDa 0.0256298
SIN3A SIN3 transcription regulator family member A 0.0252805
RHOA ras homolog family member A 0.0252705
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0251158

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.218984
MT2A metallothionein 2A -0.18565
IGFBP3 insulin-like growth factor binding protein 3 -0.107882
VIM vimentin -0.0898081
ACTG1 actin gamma 1 -0.0863212
TPT1 tumor protein, translationally-controlled 1 -0.0834364
IER3 immediate early response 3 -0.0799437
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0759781
RPS8 ribosomal protein S8 -0.0759674
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0725001
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0722995
THSD4 thrombospondin, type I, domain containing 4 -0.0714361
C15ORF48 chromosome 15 open reading frame 48 -0.069777
SAMD4A sterile alpha motif domain containing 4A -0.0675562
FTH1 ferritin, heavy polypeptide 1 -0.0588947
CMIP c-Maf inducing protein -0.0573048
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.057221
RPL31 ribosomal protein L31 -0.0570811
RPL35A ribosomal protein L35a -0.0569957
S100A10 S100 calcium binding protein A10 -0.055356
PYGL phosphorylase, glycogen, liver -0.0530459
EGFR epidermal growth factor receptor -0.0518557
AHNAK AHNAK nucleoprotein -0.051154
HLA-B major histocompatibility complex, class I, B -0.0508189
POTEF POTE ankyrin domain family, member F -0.0501624
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0493046
RPS27A ribosomal protein S27a -0.0472785
RPS17 ribosomal protein S17 -0.0471929
RPLP1 ribosomal protein, large, P1 -0.0468761
FAM107B family with sequence similarity 107, member B -0.0465291
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0443111
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.042531
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0424162
RPL23 ribosomal protein L23 -0.0417019
DST dystonin -0.0414806
RPS23 ribosomal protein S23 -0.0403485
S100A6 S100 calcium binding protein A6 -0.0398672
RPL19 ribosomal protein L19 -0.0397617
NDRG1 N-myc downstream regulated 1 -0.039292
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0389859
RPS29 ribosomal protein S29 -0.0388342
STC1 stanniocalcin 1 -0.0387266
PDE4D phosphodiesterase 4D, cAMP-specific -0.0380798
RPL37A ribosomal protein L37a -0.0377134
RPS24 ribosomal protein S24 -0.0373082
SH3KBP1 SH3-domain kinase binding protein 1 -0.0364736
DOCK5 dedicator of cytokinesis 5 -0.0357122
SMOC1 SPARC related modular calcium binding 1 -0.0352137
MAP1B microtubule-associated protein 1B -0.0351102
ANGPTL4 angiopoietin-like 4 -0.0349368
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0349362
RPS25 ribosomal protein S25 -0.0348402
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0346765
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0343249
CUX1 cut-like homeobox 1 -0.0342272
MYO1E myosin IE -0.0340216
AKAP12 A kinase (PRKA) anchor protein 12 -0.0338011
IGFBP4 insulin-like growth factor binding protein 4 -0.0335949
RPL34 ribosomal protein L34 -0.0335599
EXT1 exostosin glycosyltransferase 1 -0.0335466
SOD2 superoxide dismutase 2, mitochondrial -0.0324718
BASP1 brain abundant, membrane attached signal protein 1 -0.0323965
RPL26 ribosomal protein L26 -0.0323383
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0322346
USP34 ubiquitin specific peptidase 34 -0.032193
ARHGAP26 Rho GTPase activating protein 26 -0.0319404
FNDC3B fibronectin type III domain containing 3B -0.0313486
RPS15 ribosomal protein S15 -0.0313394
CTBP2 C-terminal binding protein 2 -0.0311465
LDHA lactate dehydrogenase A -0.0305413
ATXN1 ataxin 1 -0.0300455
RPS16 ribosomal protein S16 -0.0299998
EPAS1 endothelial PAS domain protein 1 -0.0299527
FLNB filamin B, beta -0.0298422
PCNX4 pecanex 4 -0.029764
RPS11 ribosomal protein S11 -0.029119
S100A9 S100 calcium binding protein A9 -0.0290408
TPM1 tropomyosin 1 (alpha) -0.0289729
GOLGA4 golgin A4 -0.0289528
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0289244
TPM4 tropomyosin 4 -0.0288238
RPL12 ribosomal protein L12 -0.0284543
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0283742
RPS6 ribosomal protein S6 -0.0282575
RPS27 ribosomal protein S27 -0.028184
ASPH aspartate beta-hydroxylase -0.0281672
IL6 interleukin 6 -0.0277607
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0274809
TRIO trio Rho guanine nucleotide exchange factor -0.0273359
BIRC6 baculoviral IAP repeat containing 6 -0.0272798
RPL37 ribosomal protein L37 -0.0271336
MAP7 microtubule-associated protein 7 -0.0271283
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0267479
HLA-E major histocompatibility complex, class I, E -0.0265729
CD44 CD44 molecule (Indian blood group) -0.026329
ANKRD11 ankyrin repeat domain 11 -0.0263285
GOLGB1 golgin B1 -0.0262627
EHBP1 EH domain binding protein 1 -0.026239
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0259858
NF1 neurofibromin 1 -0.0257213