Ranolazine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ranolazine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.311702
FN1 fibronectin 1 0.197456
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.195322
NDRG1 N-myc downstream regulated 1 0.116633
VIM vimentin 0.11438
RIGI RNA sensor RIG-I 0.112645
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.1056
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.104272
IGF2 insulin-like growth factor 2 0.104197
ERRFI1 ERBB receptor feedback inhibitor 1 0.0994909
MAST4 microtubule associated serine/threonine kinase family member 4 0.0994507
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0979492
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0944253
EGFR epidermal growth factor receptor 0.0865701
PDE10A phosphodiesterase 10A 0.0793652
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0787397
KYNU kynureninase 0.0770212
LDHA lactate dehydrogenase A 0.0751919
MYO1E myosin IE 0.0667655
UGCG UDP-glucose ceramide glucosyltransferase 0.0632008
CXCL8 chemokine (C-X-C motif) ligand 8 0.0588368
MT2A metallothionein 2A 0.0584369
BZW1 basic leucine zipper and W2 domains 1 0.0560297
TMOD3 tropomodulin 3 (ubiquitous) 0.0548016
GRAMD1B GRAM domain containing 1B 0.0536866
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0531409
PRRC2C proline-rich coiled-coil 2C 0.0529383
TACC2 transforming, acidic coiled-coil containing protein 2 0.0509932
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0507469
ZFAND3 zinc finger, AN1-type domain 3 0.0493388
BRWD1 bromodomain and WD repeat domain containing 1 0.0490894
SAMD4A sterile alpha motif domain containing 4A 0.0488248
HMGA2 high mobility group AT-hook 2 0.0476827
ZFP36L1 ZFP36 ring finger protein-like 1 0.047622
ALCAM activated leukocyte cell adhesion molecule 0.0463441
PELI1 pellino E3 ubiquitin protein ligase 1 0.0455099
ANKRD12 ankyrin repeat domain 12 0.0449094
MYOF myoferlin 0.0438238
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0436868
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0434939
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0434159
ESYT2 extended synaptotagmin-like protein 2 0.0432749
SFTPA2 surfactant protein A2 0.0431954
MYO10 myosin X 0.0430353
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0426529
ANO6 anoctamin 6 0.0424353
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0423424
AREG amphiregulin 0.0419253
SMYD3 SET and MYND domain containing 3 0.0416104
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0403681
PRKG1 protein kinase, cGMP-dependent, type I 0.0401873
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0398865
F3 coagulation factor III (thromboplastin, tissue factor) 0.0397985
EXT1 exostosin glycosyltransferase 1 0.039615
ZNF292 zinc finger protein 292 0.0394434
ACTG1 actin gamma 1 0.0389279
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0388839
GPHN gephyrin 0.0384876
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0380648
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0380496
LAMA4 laminin, alpha 4 0.0379607
ZBTB20 zinc finger and BTB domain containing 20 0.0377884
PARD3 par-3 family cell polarity regulator 0.0376144
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0372994
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0372365
FLNB filamin B, beta 0.036962
RFX7 regulatory factor X, 7 0.0368741
RTN4 reticulon 4 0.0368593
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0368167
ATXN1 ataxin 1 0.0367214
HLA-B major histocompatibility complex, class I, B 0.0366588
AHNAK AHNAK nucleoprotein 0.0364058
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0363671
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0360705
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0356178
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.035605
MYO9A myosin IXA 0.0352497
INHBA inhibin, beta A 0.0350619
OXR1 oxidation resistance 1 0.0345658
MORC3 MORC family CW-type zinc finger 3 0.0342456
FOXO3 forkhead box O3 0.0342176
N4BP2L2 NEDD4 binding protein 2-like 2 0.03411
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.033952
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0335682
ZCCHC7 zinc finger, CCHC domain containing 7 0.0330405
ARHGAP5 Rho GTPase activating protein 5 0.03211
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0318526
OXSR1 oxidative stress responsive 1 0.0318232
ZC3H11A zinc finger CCCH-type containing 11A 0.0314267
WWC1 WW and C2 domain containing 1 0.0311386
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0311193
S100A9 S100 calcium binding protein A9 0.0310595
SEC31A SEC31 homolog A (S. cerevisiae) 0.0307295
SLC38A2 solute carrier family 38, member 2 0.0301699
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0300051
RRBP1 ribosome binding protein 1 0.0296903
DST dystonin 0.0296691
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0295984
MPRIP myosin phosphatase Rho interacting protein 0.0294167
SETD5 SET domain containing 5 0.0293106

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.13029
MUC16 mucin 16, cell surface associated -0.111927
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.111638
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.093431
LAMC2 laminin, gamma 2 -0.0929869
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0850338
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0829191
FTL ferritin, light polypeptide -0.0733971
GCLC glutamate-cysteine ligase, catalytic subunit -0.0662949
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0640451
SLC38A1 solute carrier family 38, member 1 -0.0614852
TRA2A transformer 2 alpha homolog (Drosophila) -0.0587587
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0580353
GRB10 growth factor receptor-bound protein 10 -0.0577788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0561528
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0560281
ACVR1 activin A receptor, type I -0.055454
DICER1 dicer 1, ribonuclease type III -0.0554354
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0552733
NPTN neuroplastin -0.0549133
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0544483
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0535482
WASF2 WAS protein family, member 2 -0.0525389
SRPK2 SRSF protein kinase 2 -0.0510534
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0505966
SAMD9 sterile alpha motif domain containing 9 -0.0501001
OGA O-GlcNAcase -0.0492889
CD2AP CD2-associated protein -0.0486855
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.04788
TJP1 tight junction protein 1 -0.0470114
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0469571
MCU mitochondrial calcium uniporter -0.0464577
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0463461
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0461918
MTDH metadherin -0.0461752
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0454883
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0453389
AFF4 AF4/FMR2 family, member 4 -0.0449245
SPNS2 spinster homolog 2 (Drosophila) -0.0447866
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0447162
GNAS GNAS complex locus -0.0447144
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0444738
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0442905
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0442089
ITCH itchy E3 ubiquitin protein ligase -0.0441642
ANKRD36C ankyrin repeat domain 36C -0.0436465
GOLGA4 golgin A4 -0.0435596
SAMD12 sterile alpha motif domain containing 12 -0.0434755
MARCHF6 membrane associated ring-CH-type finger 6 -0.043175
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0421327
UBC ubiquitin C -0.0418865
RASA2 RAS p21 protein activator 2 -0.0404657
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0400169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398851
USP34 ubiquitin specific peptidase 34 -0.0397828
NEBL nebulette -0.0394138
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.039316
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0385667
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0384244
JUN jun proto-oncogene -0.0381025
ATOSA atos homolog A -0.0380814
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.037975
RICTOR RPTOR independent companion of MTOR, complex 2 -0.037914
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0378359
RPS29 ribosomal protein S29 -0.0377596
MYO6 myosin VI -0.0374321
NCOA7 nuclear receptor coactivator 7 -0.0371175
SCEL sciellin -0.0370374
TMEM87A transmembrane protein 87A -0.0365872
CANX calnexin -0.0364544
SMAD3 SMAD family member 3 -0.0364369
CEMIP cell migration inducing protein, hyaluronan binding -0.0362994
MED13L mediator complex subunit 13-like -0.036264
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0362612
FAM107B family with sequence similarity 107, member B -0.0362445
RB1CC1 RB1-inducible coiled-coil 1 -0.0358772
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0356389
AFAP1 actin filament associated protein 1 -0.0355983
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0355954
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0353453
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0349565
MRPS6 mitochondrial ribosomal protein S6 -0.0343581
NEK7 NIMA-related kinase 7 -0.0341779
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0341211
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0339197
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0339068
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0338227
KIF13B kinesin family member 13B -0.0336417
NCOR1 nuclear receptor corepressor 1 -0.0333495
HM13 histocompatibility (minor) 13 -0.0333486
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0333237
INTS6 integrator complex subunit 6 -0.0331466
POTEF POTE ankyrin domain family, member F -0.0328469
SOD2 superoxide dismutase 2, mitochondrial -0.0326579
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0326392
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0325851
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0324581
SKP1 S-phase kinase-associated protein 1 -0.0324355
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.032391
RYBP RING1 and YY1 binding protein -0.0323772