| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ranolazine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ranolazine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.101936 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.100127 |
| GDA | guanine deaminase | 0.0886843 |
| EFNA5 | ephrin-A5 | 0.0746411 |
| DST | dystonin | 0.0648351 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0625004 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0593532 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0527367 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0484533 |
| DNER | delta/notch-like EGF repeat containing | 0.0425554 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0424566 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0413018 |
| NPAS2 | neuronal PAS domain protein 2 | 0.038411 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0380176 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0375047 |
| ATP13A3 | ATPase type 13A3 | 0.03607 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0358904 |
| NRCAM | neuronal cell adhesion molecule | 0.0350212 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0347234 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0344513 |
| TXNRD1 | thioredoxin reductase 1 | 0.0335407 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0328763 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0324028 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0323535 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0317785 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0312532 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0284257 |
| FLNB | filamin B, beta | 0.0280549 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0277869 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0259711 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0255918 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.02557 |
| CTSC | cathepsin C | 0.0255169 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0254886 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0248428 |
| EPGN | epithelial mitogen | 0.0244391 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.02383 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0238116 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0230963 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0228204 |
| RNF145 | ring finger protein 145 | 0.0227589 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0227462 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0220891 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.021929 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0212864 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0202938 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0197548 |
| GRAMD1B | GRAM domain containing 1B | 0.0196994 |
| RPLP0 | ribosomal protein, large, P0 | 0.0193184 |
| DIAPH3 | diaphanous-related formin 3 | 0.0190335 |
| TOP1 | topoisomerase (DNA) I | 0.0188907 |
| NGLY1 | N-glycanase 1 | 0.0186802 |
| TNPO1 | transportin 1 | 0.0185542 |
| USP3 | ubiquitin specific peptidase 3 | 0.0185159 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0183361 |
| ZNF292 | zinc finger protein 292 | 0.0181777 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0181331 |
| NRG1 | neuregulin 1 | 0.0175467 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0170271 |
| RTN4 | reticulon 4 | 0.0170027 |
| GOLGA4 | golgin A4 | 0.0168635 |
| THOC2 | THO complex 2 | 0.0168616 |
| GPC6 | glypican 6 | 0.0166984 |
| PRKD3 | protein kinase D3 | 0.0166688 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0165375 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0164493 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0164109 |
| MED13 | mediator complex subunit 13 | 0.0163964 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0163301 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0162693 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0159483 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0158762 |
| CD44 | CD44 molecule (Indian blood group) | 0.0155456 |
| MFF | mitochondrial fission factor | 0.0155035 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0153437 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0149235 |
| ITGAV | integrin, alpha V | 0.0148886 |
| WDR43 | WD repeat domain 43 | 0.0148388 |
| RPL4 | ribosomal protein L4 | 0.0147469 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0146672 |
| HEATR1 | HEAT repeat containing 1 | 0.0141312 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0140842 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0140527 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0140306 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.013949 |
| PGK1 | phosphoglycerate kinase 1 | 0.0139094 |
| PHF20 | PHD finger protein 20 | 0.0138892 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.013851 |
| RPS4X | ribosomal protein S4, X-linked | 0.0138117 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0138029 |
| ERBIN | erbb2 interacting protein | 0.0137975 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0137659 |
| PTEN | phosphatase and tensin homolog | 0.0137448 |
| SRGN | serglycin | 0.0137067 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0135345 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0134746 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0134692 |
| STC2 | stanniocalcin 2 | 0.0134329 |
| NBEAL1 | neurobeachin-like 1 | 0.0134225 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.013399 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.248636 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.154646 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.144424 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.114742 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0943846 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0771739 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0763217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0632956 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0602903 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0584638 |
| EGR1 | early growth response 1 | -0.05744 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0535951 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.052411 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0508917 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0451094 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0441829 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0440984 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0436209 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0414077 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0413325 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.041186 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0404026 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0398515 |
| VCL | vinculin | -0.0395962 |
| COL5A2 | collagen, type V, alpha 2 | -0.03952 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.037546 |
| ASPH | aspartate beta-hydroxylase | -0.0365927 |
| IL6 | interleukin 6 | -0.0361248 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0349423 |
| SMAD2 | SMAD family member 2 | -0.0328061 |
| CANX | calnexin | -0.0318044 |
| VIM | vimentin | -0.0314522 |
| RIGI | RNA sensor RIG-I | -0.0311112 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0310481 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0304959 |
| EZR | ezrin | -0.0297975 |
| TMSB10 | thymosin beta 10 | -0.0297121 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0288138 |
| MAP7 | microtubule-associated protein 7 | -0.0286627 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0283749 |
| SMYD3 | SET and MYND domain containing 3 | -0.0283267 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0280176 |
| LSAMP | limbic system-associated membrane protein | -0.027147 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0265464 |
| YBX3 | Y box binding protein 3 | -0.0264234 |
| NDRG1 | N-myc downstream regulated 1 | -0.0263354 |
| LAMA1 | laminin, alpha 1 | -0.0261644 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0260597 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0258698 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0257324 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0255665 |
| PALLD | palladin, cytoskeletal associated protein | -0.025366 |
| ENO1 | enolase 1, (alpha) | -0.0249672 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0247399 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0246791 |
| TPM4 | tropomyosin 4 | -0.0245159 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0243566 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0241285 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0240603 |
| FOXK1 | forkhead box K1 | -0.0240202 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0234889 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0233626 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0233183 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0228962 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0228054 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.022789 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0226244 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0225374 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.022396 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0221698 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0220312 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0219338 |
| CALR | calreticulin | -0.0219045 |
| KIAA0825 | KIAA0825 | -0.021902 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0218866 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0214179 |
| PTMA | prothymosin, alpha | -0.0213531 |
| JUN | jun proto-oncogene | -0.0213138 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0212361 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0209645 |
| EPHA4 | EPH receptor A4 | -0.020905 |
| TBXT | T-box transcription factor T | -0.0208147 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0207368 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0204879 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0202614 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0201856 |
| OXSR1 | oxidative stress responsive 1 | -0.0194807 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0192225 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0192081 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0189678 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0187069 |
| INHBA | inhibin, beta A | -0.0184866 |
| PDE7B | phosphodiesterase 7B | -0.0184211 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0183769 |
| CREM | cAMP responsive element modulator | -0.0179615 |
| LAMA5 | laminin, alpha 5 | -0.0179075 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0176526 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0173924 |
| CADM2 | cell adhesion molecule 2 | -0.0173647 |
| S100A10 | S100 calcium binding protein A10 | -0.0172935 |
