Ranolazine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ranolazine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

137 genes differentially expressed following the Ranolazine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.156191
GRAMD1B GRAM domain containing 1B 0.155878
JARID2 jumonji, AT rich interactive domain 2 0.147351
FXR1 fragile X mental retardation, autosomal homolog 1 0.126026
EGFR epidermal growth factor receptor 0.125067
COL5A2 collagen, type V, alpha 2 0.123569
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.121179
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.117329
TSC22D2 TSC22 domain family, member 2 0.108123
B2M beta-2-microglobulin 0.10436
RUNX1 runt-related transcription factor 1 0.0989185
EPS8 epidermal growth factor receptor pathway substrate 8 0.0963883
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0963706
PHF3 PHD finger protein 3 0.0962255
ITCH itchy E3 ubiquitin protein ligase 0.0955677
RPS16 ribosomal protein S16 0.0940912
CCNL1 cyclin L1 0.0936077
FN1 fibronectin 1 0.0928866
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0859598
TOP1 topoisomerase (DNA) I 0.0807372
ZNF292 zinc finger protein 292 0.0800182
PKM pyruvate kinase, muscle 0.0761452
WWTR1 WW domain containing transcription regulator 1 0.074784
USP3 ubiquitin specific peptidase 3 0.0729531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0659011
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0646265
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0619651
PDLIM5 PDZ and LIM domain 5 0.0593918
MAML3 mastermind-like 3 (Drosophila) 0.0558456
GNAS GNAS complex locus 0.0549189
EFNA5 ephrin-A5 0.0527582
AKAP12 A kinase (PRKA) anchor protein 12 0.0493876
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0472354
ZMYM2 zinc finger, MYM-type 2 0.044012
WSB1 WD repeat and SOCS box containing 1 0.0437545
PARD3 par-3 family cell polarity regulator 0.0428656
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0411425
ADNP activity-dependent neuroprotector homeobox 0.0402736
SPAG9 sperm associated antigen 9 0.0389786
ASPH aspartate beta-hydroxylase 0.0386992
FNDC3B fibronectin type III domain containing 3B 0.0381329
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0374487
MED13 mediator complex subunit 13 0.0368868
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0366601
KDM5B lysine (K)-specific demethylase 5B 0.0329256
TXNRD1 thioredoxin reductase 1 0.0322603
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0316323
BIRC6 baculoviral IAP repeat containing 6 0.0314591
MEF2A myocyte enhancer factor 2A 0.0309473
TRIO trio Rho guanine nucleotide exchange factor 0.0238634
JMJD1C jumonji domain containing 1C 0.0237776
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0237689
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0227487
MT2A metallothionein 2A 0.0202014
PTK2 protein tyrosine kinase 2 0.0167308
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0144511
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0111506
EIF1 eukaryotic translation initiation factor 1 0.0110838
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00962637
TMSB10 thymosin beta 10 0.00905374
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00846942
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00636253
PGK1 phosphoglycerate kinase 1 0.00297423
RASA3 RAS p21 protein activator 3 6.99198E-4
SBF2 SET binding factor 2 3.7086E-4
EXT1 exostosin glycosyltransferase 1 7.8515E-5

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.273552
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249607
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.180342
GPC6 glypican 6 -0.151996
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.148271
KMT2C lysine (K)-specific methyltransferase 2C -0.142053
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137235
PTMA prothymosin, alpha -0.122218
VMP1 vacuole membrane protein 1 -0.118949
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.113693
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.108012
MACF1 microtubule-actin crosslinking factor 1 -0.103944
PCCA propionyl CoA carboxylase, alpha polypeptide -0.102486
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0912545
NALF1 NALCN channel auxiliary factor 1 -0.0860044
PDE10A phosphodiesterase 10A -0.0829028
VIM vimentin -0.0811381
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0739967
KMT2E lysine (K)-specific methyltransferase 2E -0.0690004
ACTG1 actin gamma 1 -0.067753
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0669482
GOLGA4 golgin A4 -0.0586827
TRA2A transformer 2 alpha homolog (Drosophila) -0.0566363
PRRC2C proline-rich coiled-coil 2C -0.0559899
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0547904
RPL35A ribosomal protein L35a -0.0537842
ANKRD11 ankyrin repeat domain 11 -0.0530966
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0524567
FLNB filamin B, beta -0.0516679
RORA RAR-related orphan receptor A -0.0487146
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0481897
MYOF myoferlin -0.0431164
ATP13A3 ATPase type 13A3 -0.0430859
NAMPT nicotinamide phosphoribosyltransferase -0.0425438
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0423321
NAP1L1 nucleosome assembly protein 1-like 1 -0.0419244
SRPK2 SRSF protein kinase 2 -0.0396579
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0374863
ANKRD12 ankyrin repeat domain 12 -0.0361212
RPS6 ribosomal protein S6 -0.0336496
DST dystonin -0.031987
ZFAND3 zinc finger, AN1-type domain 3 -0.0318865
RAP1B RAP1B, member of RAS oncogene family -0.0312362
LDHA lactate dehydrogenase A -0.0301977
NCOR1 nuclear receptor corepressor 1 -0.0283896
IGFBP5 insulin-like growth factor binding protein 5 -0.0250697
ENO1 enolase 1, (alpha) -0.0218468
TPT1 tumor protein, translationally-controlled 1 -0.0210868
WAC WW domain containing adaptor with coiled-coil -0.0206669
KTN1 kinectin 1 (kinesin receptor) -0.0185796
NPAS2 neuronal PAS domain protein 2 -0.0180239
CHD1 chromodomain helicase DNA binding protein 1 -0.0163555
TTC3 tetratricopeptide repeat domain 3 -0.015545
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.015525
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0139021
OGA O-GlcNAcase -0.0134903
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0130325
PRELID2 PRELI domain containing 2 -0.0126332
IGFBP3 insulin-like growth factor binding protein 3 -0.0124611
MYO1E myosin IE -0.0120387
DSCAM Down syndrome cell adhesion molecule -0.00981566
USP34 ubiquitin specific peptidase 34 -0.00891355
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00733507
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00710354
LMO7 LIM domain 7 -0.00689082
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.00601342
RPL23 ribosomal protein L23 -0.00404855
MON2 MON2 homolog (S. cerevisiae) -0.00241191
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00219409
CHD9 chromodomain helicase DNA binding protein 9 -0.00119307
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -9.41244E-4