Rap1 signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types. (Kyoto Encyclopedia of Genes and Genomes, hsa04015)
External Link https://www.kegg.jp/entry/hsa04015
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Genes

210 proteins participating in the Rap1 signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
AFDN afadin, adherens junction formation factor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPT4 angiopoietin 4
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
BCAR1 breast cancer anti-estrogen resistance 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CDC42 cell division cycle 42
CLSTN1 calsyntenin 1
CNKSR3 CNKSR family member 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DOCK4 dedicator of cytokinesis 4
DRD2 dopamine receptor D2
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA4-EFNA3 EFNA4-EFNA3 readthrough
EFNA5 ephrin-A5
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENAH enabled homolog (Drosophila)
EPHA2 EPH receptor A2
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
F2RL3 coagulation factor II (thrombin) receptor-like 3
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FPR1 formyl peptide receptor 1
FYB1 FYN binding protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HRAS Harvey rat sarcoma viral oncogene homolog
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
INS insulin
INSR insulin receptor
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KRIT1 KRIT1, ankyrin repeat containing
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LNCEGFL7OS lncRNA EGFL7 opposite strand
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR5 lysophosphatidic acid receptor 5
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MRAS muscle RAS oncogene homolog
NCOA3 nuclear receptor coactivator 3
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PCDHA4 protocadherin alpha 4
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PFN1 profilin 1
PFN2 profilin 2
PFN3 profilin 3
PFN4 profilin family, member 4
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
POTEF POTE ankyrin domain family, member F
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RALGDS ral guanine nucleotide dissociation stimulator
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RGS14 regulator of G-protein signaling 14
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
RRAS related RAS viral (r-ras) oncogene homolog
SIPA1 signal-induced proliferation-associated 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKAP1 src kinase associated phosphoprotein 1
SLTM SAFB-like, transcription modulator
SOS1 son of sevenless homolog 1 (Drosophila)
SPNS1 spinster homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TEK TEK tyrosine kinase, endothelial
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN1 talin 1
TLN2 talin 2
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VEGFD vascular endothelial growth factor D