Rapamycin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.152548
PODXL podocalyxin-like 0.149059
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.121349
IGFBP3 insulin-like growth factor binding protein 3 0.119241
SLC39A11 solute carrier family 39, member 11 0.10579
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0923644
EGFR epidermal growth factor receptor 0.0888346
CSTB cystatin B (stefin B) 0.0756244
PBX3 pre-B-cell leukemia homeobox 3 0.0719543
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0682313
CDH13 cadherin 13 0.0682199
COL5A1 collagen, type V, alpha 1 0.0681627
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0669649
TRIO trio Rho guanine nucleotide exchange factor 0.0624451
HDAC9 histone deacetylase 9 0.055582
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0551525
AHNAK2 AHNAK nucleoprotein 2 0.0539889
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0530502
ANKRD11 ankyrin repeat domain 11 0.0502976
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0477537
FN1 fibronectin 1 0.0469049
TIMP2 TIMP metallopeptidase inhibitor 2 0.0446159
CYTH3 cytohesin 3 0.0416831
MSI2 musashi RNA-binding protein 2 0.0402195
EEF2 eukaryotic translation elongation factor 2 0.0394283
FLNA filamin A, alpha 0.0381175
MYADM myeloid-associated differentiation marker 0.0381109
BSG basigin (Ok blood group) 0.0368089
DSPP dentin sialophosphoprotein 0.0364783
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0356054
MSN moesin 0.0341578
DOCK5 dedicator of cytokinesis 5 0.0340033
DGKG diacylglycerol kinase, gamma 90kDa 0.0334469
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0330951
COPA coatomer protein complex, subunit alpha 0.0324538
VEGFA vascular endothelial growth factor A 0.0321165
PLEC plectin 0.0317818
SORBS2 sorbin and SH3 domain containing 2 0.0313676
NCOR2 nuclear receptor corepressor 2 0.0312162
RND3 Rho family GTPase 3 0.0310377
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0307786
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0300978
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0300525
MACF1 microtubule-actin crosslinking factor 1 0.0299993
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0297617
MYH9 myosin, heavy chain 9, non-muscle 0.0297295
L1CAM L1 cell adhesion molecule 0.029423
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0293712
CALR calreticulin 0.0292535
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0289891
C1D C1D nuclear receptor corepressor 0.0287569
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285431
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0284897
ABI3BP ABI family, member 3 (NESH) binding protein 0.0279276
CLIP2 CAP-GLY domain containing linker protein 2 0.0272665
RASAL2 RAS protein activator like 2 0.0271032
AKAP9 A kinase (PRKA) anchor protein 9 0.0267007
EFNA5 ephrin-A5 0.0265918
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0265512
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0263284
ASPH aspartate beta-hydroxylase 0.0258621
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0258215
TPM3 tropomyosin 3 0.025282
GOLGB1 golgin B1 0.0250869
SEPTIN9 septin 9 0.0250043
PPARD peroxisome proliferator-activated receptor delta 0.0248325
PLXNA2 plexin A2 0.0248076
SPIRE1 spire-type actin nucleation factor 1 0.0242263
NPC1 Niemann-Pick disease, type C1 0.0232008
CD109 CD109 molecule 0.0224464
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0223585
ERBIN erbb2 interacting protein 0.0221716
RAB7A RAB7A, member RAS oncogene family 0.0216675
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0215594
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0214675
DCLK2 doublecortin-like kinase 2 0.0211337
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0207444
ANKRD30B ankyrin repeat domain 30B 0.020514
EZR ezrin 0.020209
TAC4 tachykinin 4 (hemokinin) 0.0201878
TPM4 tropomyosin 4 0.0199064
ENO2 enolase 2 (gamma, neuronal) 0.0197902
RNF144A ring finger protein 144A 0.0197806
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0196286
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0194014
COL4A1 collagen, type IV, alpha 1 0.0192686
GOLGA4 golgin A4 0.0187525
NAV1 neuron navigator 1 0.0186852
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.018669
SASH1 SAM and SH3 domain containing 1 0.0185057
FMN2 formin 2 0.0184128
MCL1 myeloid cell leukemia 1 0.0180497
AXL AXL receptor tyrosine kinase 0.0179787
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0178583
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0178285
CENPF centromere protein F, 350/400kDa 0.017693
PDLIM5 PDZ and LIM domain 5 0.0174866
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0173978
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0173723
BTBD10 BTB (POZ) domain containing 10 0.0171305

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.203343
TMSB10 thymosin beta 10 -0.155138
FBN1 fibrillin 1 -0.149082
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.146042
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134716
COL1A2 collagen, type I, alpha 2 -0.11257
UBC ubiquitin C -0.111375
COL3A1 collagen, type III, alpha 1 -0.0953807
MT2A metallothionein 2A -0.0900775
AHNAK AHNAK nucleoprotein -0.0776957
CD44 CD44 molecule (Indian blood group) -0.0680782
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0678086
SOD2 superoxide dismutase 2, mitochondrial -0.0606049
HLA-B major histocompatibility complex, class I, B -0.0597873
PTMA prothymosin, alpha -0.0597745
NAP1L1 nucleosome assembly protein 1-like 1 -0.0591885
GPC6 glypican 6 -0.0578739
B2M beta-2-microglobulin -0.056529
MX2 MX dynamin-like GTPase 2 -0.0559523
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0557699
DPYSL3 dihydropyrimidinase-like 3 -0.0549765
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0527791
STC1 stanniocalcin 1 -0.0518571
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0491351
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0470962
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0463726
SQSTM1 sequestosome 1 -0.0456115
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0430949
IFI16 interferon, gamma-inducible protein 16 -0.0428187
PSD3 pleckstrin and Sec7 domain containing 3 -0.0426669
S100A10 S100 calcium binding protein A10 -0.0418036
COL8A1 collagen, type VIII, alpha 1 -0.0412375
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0403307
MEIS2 Meis homeobox 2 -0.039164
IFIH1 interferon induced with helicase C domain 1 -0.0385341
LDHA lactate dehydrogenase A -0.0385305
ZBTB20 zinc finger and BTB domain containing 20 -0.0379277
OGA O-GlcNAcase -0.0376696
FNDC3B fibronectin type III domain containing 3B -0.0367441
DLG1 discs, large homolog 1 (Drosophila) -0.0366665
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0359739
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0358909
PLAT plasminogen activator, tissue -0.0357178
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0356359
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0354492
HLA-C major histocompatibility complex, class I, C -0.0352616
LOX lysyl oxidase -0.0347367
TPT1 tumor protein, translationally-controlled 1 -0.034639
ANKRD10 ankyrin repeat domain 10 -0.0341197
RIGI RNA sensor RIG-I -0.0334977
PRELID2 PRELI domain containing 2 -0.0330917
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.032862
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0321656
CD99 CD99 molecule -0.0319191
LOXL2 lysyl oxidase-like 2 -0.0317401
SBF2 SET binding factor 2 -0.0315848
IFITM3 interferon induced transmembrane protein 3 -0.0307467
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0304435
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0298897
CDK6 cyclin-dependent kinase 6 -0.0297479
ATP13A3 ATPase type 13A3 -0.0295048
RPS24 ribosomal protein S24 -0.0288153
COL5A2 collagen, type V, alpha 2 -0.0288016
ARL4C ADP-ribosylation factor-like 4C -0.0287745
KDM3A lysine (K)-specific demethylase 3A -0.0285148
ZNFX1 zinc finger, NFX1-type containing 1 -0.0282843
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0282311
SDC4 syndecan 4 -0.0279966
THBS2 thrombospondin 2 -0.027937
XPO1 exportin 1 -0.0278909
GNAS GNAS complex locus -0.0277838
TDRD7 tudor domain containing 7 -0.0277181
WTAP Wilms tumor 1 associated protein -0.0268826
IFITM1 interferon induced transmembrane protein 1 -0.0268681
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0268272
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0267224
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0263685
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.026366
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.026176
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0260703
TNIP1 TNFAIP3 interacting protein 1 -0.0260043
ARL15 ADP-ribosylation factor-like 15 -0.0259291
LRRC49 leucine rich repeat containing 49 -0.0258164
H3-3B H3.3 histone B -0.0257951
NPR2 natriuretic peptide receptor 2 -0.0257549
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0257354
TMOD1 tropomodulin 1 -0.0257089
KIFAP3 kinesin-associated protein 3 -0.0256477
MARCHF6 membrane associated ring-CH-type finger 6 -0.0255371
NAMPT nicotinamide phosphoribosyltransferase -0.0254366
SDK1 sidekick cell adhesion molecule 1 -0.0247773
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0242194
HLA-E major histocompatibility complex, class I, E -0.0240791
ADAR adenosine deaminase, RNA-specific -0.0240108
SPDYA speedy/RINGO cell cycle regulator family member A -0.0239863
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0238075
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0237647
TRIM56 tripartite motif containing 56 -0.0234501
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0234391
PDE4D phosphodiesterase 4D, cAMP-specific -0.0233917