Rapamycin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.237505
PLAT plasminogen activator, tissue 0.132582
ANTXR1 anthrax toxin receptor 1 0.0930105
EEF2 eukaryotic translation elongation factor 2 0.082916
EXT1 exostosin glycosyltransferase 1 0.081161
CEMIP cell migration inducing protein, hyaluronan binding 0.0773194
FNDC3B fibronectin type III domain containing 3B 0.0757442
LSAMP limbic system-associated membrane protein 0.074563
VEGFA vascular endothelial growth factor A 0.0723103
RPTOR regulatory associated protein of MTOR, complex 1 0.0623709
FAM13A family with sequence similarity 13, member A 0.0606229
MEF2A myocyte enhancer factor 2A 0.0594036
VCL vinculin 0.0578849
PCBP2 poly(rC) binding protein 2 0.0553809
ZBTB20 zinc finger and BTB domain containing 20 0.0552557
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0551814
TIMP3 TIMP metallopeptidase inhibitor 3 0.0541156
FLNB filamin B, beta 0.0517126
PCBP3 poly(rC) binding protein 3 0.050391
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0502079
KCTD16 potassium channel tetramerization domain containing 16 0.0495731
IGFBP3 insulin-like growth factor binding protein 3 0.0486833
COL4A2 collagen, type IV, alpha 2 0.0483718
VMP1 vacuole membrane protein 1 0.0480542
PACS1 phosphofurin acidic cluster sorting protein 1 0.0475201
N4BP2L2 NEDD4 binding protein 2-like 2 0.0455835
ITPRID2 ITPR interacting domain containing 2 0.0450327
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0429993
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0423015
TIMP2 TIMP metallopeptidase inhibitor 2 0.0417626
FLT1 fms-related tyrosine kinase 1 0.0415478
FRMD4A FERM domain containing 4A 0.0411891
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0409612
BPTF bromodomain PHD finger transcription factor 0.0407221
MCL1 myeloid cell leukemia 1 0.0403881
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0403367
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0398126
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0393663
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.038354
ADARB1 adenosine deaminase, RNA-specific, B1 0.0380364
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0377797
EPAS1 endothelial PAS domain protein 1 0.0372908
TPST1 tyrosylprotein sulfotransferase 1 0.0369245
THSD4 thrombospondin, type I, domain containing 4 0.0362649
TPM1 tropomyosin 1 (alpha) 0.0358024
CADM1 cell adhesion molecule 1 0.0353378
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0352944
SIK2 salt-inducible kinase 2 0.034224
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.034216
IGFBP5 insulin-like growth factor binding protein 5 0.0339772
PTPRM protein tyrosine phosphatase, receptor type, M 0.0335791
FNDC3A fibronectin type III domain containing 3A 0.0333892
GPC5 glypican 5 0.0332103
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0332072
MYH9 myosin, heavy chain 9, non-muscle 0.0326765
LIMCH1 LIM and calponin homology domains 1 0.0313232
FAM219A family with sequence similarity 219, member A 0.0311353
CUX2 cut-like homeobox 2 0.030876
LINGO2 leucine rich repeat and Ig domain containing 2 0.0308743
GAS7 growth arrest-specific 7 0.0308699
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0308699
VCAN versican 0.0305415
SLITRK6 SLIT and NTRK-like family, member 6 0.0303176
AHR aryl hydrocarbon receptor 0.0302055
ARHGAP9 Rho GTPase activating protein 9 0.0301899
ADGRB3 adhesion G protein-coupled receptor B3 0.0296892
COL5A1 collagen, type V, alpha 1 0.0296848
RAP1B RAP1B, member of RAS oncogene family 0.0295739
EGR1 early growth response 1 0.0292321
ANKRD50 ankyrin repeat domain 50 0.0291759
ARHGAP42 Rho GTPase activating protein 42 0.0290333
COL4A5 collagen, type IV, alpha 5 0.0284263
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0281842
GAB2 GRB2-associated binding protein 2 0.0280276
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0273564
GOLGB1 golgin B1 0.0273052
PTPRE protein tyrosine phosphatase, receptor type, E 0.0264043
FTH1 ferritin, heavy polypeptide 1 0.0263619
CALD1 caldesmon 1 0.0260413
HIP1 huntingtin interacting protein 1 0.0257409
EIF4B eukaryotic translation initiation factor 4B 0.025727
CTSB cathepsin B 0.0256509
RPL3 ribosomal protein L3 0.025647
STC1 stanniocalcin 1 0.0256444
RAI14 retinoic acid induced 14 0.0253457
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0253029
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025269
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0251996
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0251263
ZCCHC7 zinc finger, CCHC domain containing 7 0.0245846
IL4R interleukin 4 receptor 0.0245783
SCARB1 scavenger receptor class B, member 1 0.0244653
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0242057
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0239498
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0238923
LOXL2 lysyl oxidase-like 2 0.0236665
GOLGA2 golgin A2 0.0236104
PDE10A phosphodiesterase 10A 0.0235731
NDRG1 N-myc downstream regulated 1 0.0234196
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0232792

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.235914
PTMA prothymosin, alpha -0.13831
IGF2 insulin-like growth factor 2 -0.0847902
LPIN1 lipin 1 -0.0842527
COL1A1 collagen, type I, alpha 1 -0.0841576
FMN1 formin 1 -0.0813742
VIM vimentin -0.0748898
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0707039
SYT1 synaptotagmin I -0.0698631
SOS1 son of sevenless homolog 1 (Drosophila) -0.0674696
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0630608
ACTG1 actin gamma 1 -0.0616432
RPL38 ribosomal protein L38 -0.0612549
NCAM2 neural cell adhesion molecule 2 -0.0610231
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0574033
TRIB2 tribbles pseudokinase 2 -0.0548302
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0515865
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0515649
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0506646
H3-3B H3.3 histone B -0.0504295
RPS24 ribosomal protein S24 -0.0489757
LMNA lamin A/C -0.0457043
AHNAK AHNAK nucleoprotein -0.0432464
TMSB10 thymosin beta 10 -0.0423911
GNAS GNAS complex locus -0.042327
IFI16 interferon, gamma-inducible protein 16 -0.0419062
MEIS2 Meis homeobox 2 -0.0414991
NCOR1 nuclear receptor corepressor 1 -0.0414664
ZNF804A zinc finger protein 804A -0.0399753
RPL23 ribosomal protein L23 -0.0388454
ZMYM2 zinc finger, MYM-type 2 -0.038518
KDM3A lysine (K)-specific demethylase 3A -0.0377394
UNC5C unc-5 homolog C (C. elegans) -0.0376991
NPEPPS aminopeptidase puromycin sensitive -0.0374813
PTPRK protein tyrosine phosphatase, receptor type, K -0.0353266
CCND1 cyclin D1 -0.0349073
COL3A1 collagen, type III, alpha 1 -0.0347566
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0344956
TPT1 tumor protein, translationally-controlled 1 -0.0344651
CENPF centromere protein F, 350/400kDa -0.0343149
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0340641
HAND2 heart and neural crest derivatives expressed 2 -0.0340239
RPL35A ribosomal protein L35a -0.033417
RAD21 RAD21 homolog (S. pombe) -0.0316454
MAP1B microtubule-associated protein 1B -0.0309474
RIGI RNA sensor RIG-I -0.0307012
WSB1 WD repeat and SOCS box containing 1 -0.0302171
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0302016
RPL32 ribosomal protein L32 -0.0300613
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0298821
HMGB2 high mobility group box 2 -0.029453
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0294124
PTK2 protein tyrosine kinase 2 -0.0294044
RNF213 ring finger protein 213 -0.0291358
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.028757
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.028685
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0286767
VDAC1 voltage-dependent anion channel 1 -0.0280004
RPLP0 ribosomal protein, large, P0 -0.0275175
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0274771
TNRC6A trinucleotide repeat containing 6A -0.0271254
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0270444
NRG1 neuregulin 1 -0.0268837
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.026842
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0263406
PDZRN3 PDZ domain containing ring finger 3 -0.0261271
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259694
RPL34 ribosomal protein L34 -0.0258529
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0257687
GPHN gephyrin -0.0257037
KDM5B lysine (K)-specific demethylase 5B -0.025612
LMAN1 lectin, mannose-binding, 1 -0.0255291
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0255057
SEPTIN2 septin 2 -0.0253876
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0253445
DIAPH3 diaphanous-related formin 3 -0.0253271
MARCKS myristoylated alanine-rich protein kinase C substrate -0.02515
LRP1B low density lipoprotein receptor-related protein 1B -0.0250099
TNPO1 transportin 1 -0.0247813
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0246738
SEC63 SEC63 homolog (S. cerevisiae) -0.024364
KIF21A kinesin family member 21A -0.0241982
SCLT1 sodium channel and clathrin linker 1 -0.0241556
SPAG9 sperm associated antigen 9 -0.0240418
PLCB4 phospholipase C, beta 4 -0.023898
RPS19 ribosomal protein S19 -0.0237753
FUS FUS RNA binding protein -0.023689
RPS21 ribosomal protein S21 -0.0235575
ABI2 abl-interactor 2 -0.0235495
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0234715
XPO1 exportin 1 -0.0233989
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0233379
CKAP5 cytoskeleton associated protein 5 -0.0232889
NAP1L1 nucleosome assembly protein 1-like 1 -0.0232491
SOX4 SRY (sex determining region Y)-box 4 -0.0232277
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0232098
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0231371
CSDE1 cold shock domain containing E1, RNA-binding -0.0231219
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0230152
RPL4 ribosomal protein L4 -0.0228494