Rapamycin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.19496
DOCK5 dedicator of cytokinesis 5 0.101867
KRT17 keratin 17, type I 0.101441
GRB10 growth factor receptor-bound protein 10 0.100424
CD44 CD44 molecule (Indian blood group) 0.0928599
PODXL podocalyxin-like 0.0878867
PLEC plectin 0.0852608
ITCH itchy E3 ubiquitin protein ligase 0.0796357
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0780241
NRIP1 nuclear receptor interacting protein 1 0.0738855
ESYT2 extended synaptotagmin-like protein 2 0.0664838
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0643772
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0640058
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0627264
ITGA6 integrin, alpha 6 0.0619786
RAI14 retinoic acid induced 14 0.0581052
PTK2 protein tyrosine kinase 2 0.0571029
APP amyloid beta (A4) precursor protein 0.0569098
AOPEP aminopeptidase O (putative) 0.0561384
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0560118
RAB22A RAB22A, member RAS oncogene family 0.0558765
NAV2 neuron navigator 2 0.0549364
FRMD6 FERM domain containing 6 0.0547136
TRIO trio Rho guanine nucleotide exchange factor 0.0521537
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0521333
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0517902
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.051001
SQLE squalene epoxidase 0.0500326
IGFBP6 insulin-like growth factor binding protein 6 0.0499179
RICTOR RPTOR independent companion of MTOR, complex 2 0.0492494
FNIP1 folliculin interacting protein 1 0.049187
EZR ezrin 0.048885
EGFR epidermal growth factor receptor 0.0484231
CANX calnexin 0.0483767
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.047934
ITSN1 intersectin 1 (SH3 domain protein) 0.0477681
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0473793
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0464917
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0461299
MYOF myoferlin 0.0460578
FNDC3A fibronectin type III domain containing 3A 0.0460027
NCOA3 nuclear receptor coactivator 3 0.045302
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0444418
NAMPT nicotinamide phosphoribosyltransferase 0.0439773
CALU calumenin 0.0432391
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0425913
EEF2 eukaryotic translation elongation factor 2 0.0424179
HDLBP high density lipoprotein binding protein 0.0421595
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0419949
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0416913
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0415097
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0410838
TSC22D1 TSC22 domain family, member 1 0.0410013
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0407431
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0403308
AFAP1 actin filament associated protein 1 0.0401336
MYH9 myosin, heavy chain 9, non-muscle 0.0399682
WASF2 WAS protein family, member 2 0.0398826
LYST lysosomal trafficking regulator 0.0398268
UBE2H ubiquitin-conjugating enzyme E2H 0.0398179
MEF2A myocyte enhancer factor 2A 0.039115
TTC3 tetratricopeptide repeat domain 3 0.0387676
BCL2L1 BCL2-like 1 0.0384653
KMT2C lysine (K)-specific methyltransferase 2C 0.0383434
KDM7A lysine (K)-specific demethylase 7A 0.0383067
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0381593
FOXO1 forkhead box O1 0.0372675
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0369214
GOLGA4 golgin A4 0.036766
KRT6A keratin 6A, type II 0.0363693
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0358465
SEC31A SEC31 homolog A (S. cerevisiae) 0.0353042
DLG1 discs, large homolog 1 (Drosophila) 0.0352822
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0352752
IGF2 insulin-like growth factor 2 0.0349382
ARHGAP29 Rho GTPase activating protein 29 0.0349018
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0348974
OSBPL3 oxysterol binding protein-like 3 0.0348808
ZEB1 zinc finger E-box binding homeobox 1 0.0347961
BCAR3 breast cancer anti-estrogen resistance 3 0.0347552
GARS1 glycyl-tRNA synthetase 1 0.0346173
AMOTL1 angiomotin like 1 0.0344152
MACF1 microtubule-actin crosslinking factor 1 0.0342689
LMO7 LIM domain 7 0.0342192
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0341002
CUL4B cullin 4B 0.0338516
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0335967
ADAM10 ADAM metallopeptidase domain 10 0.0335858
NRG1 neuregulin 1 0.0335555
RBM39 RNA binding motif protein 39 0.0332524
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0329741
ITGB4 integrin, beta 4 0.0329381
ARHGAP21 Rho GTPase activating protein 21 0.0323498
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323324
KRT14 keratin 14, type I 0.0323186
ANXA2 annexin A2 0.0322976
MPRIP myosin phosphatase Rho interacting protein 0.0320906
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0318653
OSBPL6 oxysterol binding protein-like 6 0.0318476
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0316418

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.121028
TPT1 tumor protein, translationally-controlled 1 -0.11527
MT2A metallothionein 2A -0.104264
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0838506
B2M beta-2-microglobulin -0.0772879
DPYD dihydropyrimidine dehydrogenase -0.0699764
RPLP2 ribosomal protein, large, P2 -0.0692708
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0666144
IFITM1 interferon induced transmembrane protein 1 -0.0648001
RPS24 ribosomal protein S24 -0.0642999
HLA-B major histocompatibility complex, class I, B -0.0602144
RPS19 ribosomal protein S19 -0.0583006
RPS21 ribosomal protein S21 -0.0579885
RPLP1 ribosomal protein, large, P1 -0.0570601
IFITM3 interferon induced transmembrane protein 3 -0.0566848
FTL ferritin, light polypeptide -0.0561341
INTS6 integrator complex subunit 6 -0.0558643
RPS12 ribosomal protein S12 -0.0555699
RIGI RNA sensor RIG-I -0.0538236
RAD51B RAD51 paralog B -0.0532315
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0518444
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0517432
RPL37 ribosomal protein L37 -0.0512409
KLF5 Kruppel-like factor 5 (intestinal) -0.0508215
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0499859
MAML2 mastermind-like 2 (Drosophila) -0.0497319
RPS8 ribosomal protein S8 -0.0489687
RPS3 ribosomal protein S3 -0.04851
IFI44L interferon-induced protein 44-like -0.0479183
TM4SF1 transmembrane 4 L six family member 1 -0.0476887
RPL37A ribosomal protein L37a -0.0473983
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0473408
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0469856
RPS6 ribosomal protein S6 -0.0456656
EGR1 early growth response 1 -0.0456349
ACTN4 actinin, alpha 4 -0.0433738
CRACDL CRACD like -0.0429517
IFI27 interferon, alpha-inducible protein 27 -0.0429366
RPS13 ribosomal protein S13 -0.0429075
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0421033
IFI6 interferon, alpha-inducible protein 6 -0.0397367
NDRG1 N-myc downstream regulated 1 -0.0397138
RPL11 ribosomal protein L11 -0.0388296
RPL9 ribosomal protein L9 -0.0386717
ZMYND8 zinc finger, MYND-type containing 8 -0.0386294
RPL31 ribosomal protein L31 -0.0374086
IFI44 interferon-induced protein 44 -0.0373488
KIAA1217 KIAA1217 -0.0372825
SMYD3 SET and MYND domain containing 3 -0.0372569
RPL19 ribosomal protein L19 -0.0369136
RPL34 ribosomal protein L34 -0.0365852
PDE4D phosphodiesterase 4D, cAMP-specific -0.0365553
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0358466
SULF1 sulfatase 1 -0.0357711
RPL30 ribosomal protein L30 -0.0355889
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0344514
CSMD2 CUB and Sushi multiple domains 2 -0.034008
RPS23 ribosomal protein S23 -0.0339928
RPS29 ribosomal protein S29 -0.0337967
ACTG1 actin gamma 1 -0.0335211
RPL23 ribosomal protein L23 -0.0334231
VCL vinculin -0.0333999
RPS14 ribosomal protein S14 -0.0330328
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0322848
FN1 fibronectin 1 -0.0316525
SOX5 SRY (sex determining region Y)-box 5 -0.0315862
ATP5F1E ATP synthase F1 subunit epsilon -0.0309496
WSB1 WD repeat and SOCS box containing 1 -0.0308174
PLSCR1 phospholipid scramblase 1 -0.0306867
RPL35A ribosomal protein L35a -0.0306159
RPL12 ribosomal protein L12 -0.0301623
RPS25 ribosomal protein S25 -0.0294731
MSN moesin -0.0293472
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0289287
ABI3BP ABI family, member 3 (NESH) binding protein -0.0289155
LRP1B low density lipoprotein receptor-related protein 1B -0.0288877
DOK5 docking protein 5 -0.0285037
RPL36 ribosomal protein L36 -0.027888
RAB7A RAB7A, member RAS oncogene family -0.027736
RPL35 ribosomal protein L35 -0.0274977
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0274108
CAV1 caveolin 1, caveolae protein, 22kDa -0.0272863
PCDH9 protocadherin 9 -0.0271207
RPL27A ribosomal protein L27a -0.0270972
FAF1 Fas (TNFRSF6) associated factor 1 -0.0267304
FRMD4B FERM domain containing 4B -0.0262888
EFNA5 ephrin-A5 -0.0262541
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0261535
RPL5 ribosomal protein L5 -0.0258953
DIAPH3 diaphanous-related formin 3 -0.0256692
RPS27 ribosomal protein S27 -0.0253044
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.024975
MTAP methylthioadenosine phosphorylase -0.0244478
RPL36A ribosomal protein L36a -0.0243982
RPL28 ribosomal protein L28 -0.0243738
RRBP1 ribosome binding protein 1 -0.0242199
RRM2 ribonucleotide reductase M2 -0.0239337
TMSB4X thymosin beta 4, X-linked -0.0237586
S100A2 S100 calcium binding protein A2 -0.0234317
ANGPTL4 angiopoietin-like 4 -0.0234027