Rapamycin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rapamycin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.180395
TXNRD1 thioredoxin reductase 1 0.114807
ELL2 elongation factor, RNA polymerase II, 2 0.108863
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.108791
NAMPT nicotinamide phosphoribosyltransferase 0.0942788
SLTM SAFB-like, transcription modulator 0.0933992
LMO7 LIM domain 7 0.0932217
LAMA4 laminin, alpha 4 0.090304
LAMC2 laminin, gamma 2 0.084611
STC1 stanniocalcin 1 0.0819926
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0789093
EGFR epidermal growth factor receptor 0.0745728
LAMB3 laminin, beta 3 0.0708617
H1-0 H1.0 linker histone 0.0661875
TPT1 tumor protein, translationally-controlled 1 0.0617526
PM20D1 peptidase M20 domain containing 1 0.0595524
SPAG9 sperm associated antigen 9 0.0571393
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0565621
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0552436
RPS3 ribosomal protein S3 0.0549359
ERRFI1 ERBB receptor feedback inhibitor 1 0.0533215
CES1 carboxylesterase 1 0.0522276
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0510513
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0500225
OSMR oncostatin M receptor 0.0497202
FAM13A family with sequence similarity 13, member A 0.0489852
SMAD3 SMAD family member 3 0.0482599
AHNAK2 AHNAK nucleoprotein 2 0.0478428
PGK1 phosphoglycerate kinase 1 0.0473111
BZW1 basic leucine zipper and W2 domains 1 0.0470848
CXCL8 chemokine (C-X-C motif) ligand 8 0.0459683
RICTOR RPTOR independent companion of MTOR, complex 2 0.0451625
LDHA lactate dehydrogenase A 0.043003
AKAP12 A kinase (PRKA) anchor protein 12 0.0429568
ANXA2 annexin A2 0.0427406
KDM3A lysine (K)-specific demethylase 3A 0.0419555
CEMIP cell migration inducing protein, hyaluronan binding 0.0413047
HBP1 HMG-box transcription factor 1 0.041217
RAB27B RAB27B, member RAS oncogene family 0.0406139
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0399108
NIPBL Nipped-B homolog (Drosophila) 0.0392999
EEF2 eukaryotic translation elongation factor 2 0.0382975
SOD2 superoxide dismutase 2, mitochondrial 0.0378101
ARRDC3 arrestin domain containing 3 0.0368397
BMAL2 basic helix-loop-helix ARNT like 2 0.0367123
DSPP dentin sialophosphoprotein 0.0359262
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0339884
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0336456
CDCP1 CUB domain containing protein 1 0.0335182
RNF213 ring finger protein 213 0.0331804
TES testin LIM domain protein 0.0331417
BCAR3 breast cancer anti-estrogen resistance 3 0.0327397
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0326136
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0324759
BRWD3 bromodomain and WD repeat domain containing 3 0.0322865
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0320735
RUNX1 runt-related transcription factor 1 0.031879
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0315717
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0315127
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0310412
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0307604
PRRC2C proline-rich coiled-coil 2C 0.0303148
YTHDC1 YTH domain containing 1 0.0301279
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0295263
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0295148
TOP1 topoisomerase (DNA) I 0.0294357
MXI1 MAX interactor 1, dimerization protein 0.0289913
FNBP1L formin binding protein 1-like 0.02896
NTN4 netrin 4 0.0287641
FTH1 ferritin, heavy polypeptide 1 0.0285695
PARP14 poly (ADP-ribose) polymerase family, member 14 0.028558
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0284608
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.028115
APP amyloid beta (A4) precursor protein 0.0280556
LOC112694756 uncharaterized LOC112694756 0.0280021
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0278388
RIGI RNA sensor RIG-I 0.0276007
OGA O-GlcNAcase 0.0275179
SAMD9 sterile alpha motif domain containing 9 0.0271835
NCOA7 nuclear receptor coactivator 7 0.0271516
JMJD1C jumonji domain containing 1C 0.0270688
MCTP1 multiple C2 domains, transmembrane 1 0.027031
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0268932
UVRAG UV radiation resistance associated 0.0268334
BLZF1 basic leucine zipper nuclear factor 1 0.0267697
EXOC6B exocyst complex component 6B 0.0267056
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0266412
BTG1 B-cell translocation gene 1, anti-proliferative 0.0264483
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0261493
RPLP0 ribosomal protein, large, P0 0.0259063
TBC1D22A TBC1 domain family, member 22A 0.0258972
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0257979
AHNAK AHNAK nucleoprotein 0.0254538
SEPTIN10 septin 10 0.0252136
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0250253
IQGAP1 IQ motif containing GTPase activating protein 1 0.0250229
EIF1 eukaryotic translation initiation factor 1 0.0249313
TLK1 tousled-like kinase 1 0.0248241
AGO2 argonaute RISC catalytic component 2 0.0247823
NAP1L1 nucleosome assembly protein 1-like 1 0.0244405

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.194134
PTPRM protein tyrosine phosphatase, receptor type, M -0.0887082
CST3 cystatin C -0.0847633
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0688817
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0636868
PDLIM5 PDZ and LIM domain 5 -0.0616155
EFNA5 ephrin-A5 -0.0569156
INTS6 integrator complex subunit 6 -0.0565164
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0539459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0535137
SCEL sciellin -0.0517253
PKM pyruvate kinase, muscle -0.0494124
KRT7 keratin 7, type II -0.0390151
POTEF POTE ankyrin domain family, member F -0.0374769
MCL1 myeloid cell leukemia 1 -0.0368249
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0359688
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0356136
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0347333
CUX1 cut-like homeobox 1 -0.0346117
S100A9 S100 calcium binding protein A9 -0.0339299
RPL35A ribosomal protein L35a -0.0333882
NABP1 nucleic acid binding protein 1 -0.0329381
TMOD3 tropomodulin 3 (ubiquitous) -0.0324536
PATJ PATJ crumbs cell polarity complex component -0.0318571
TNS3 tensin 3 -0.031777
PDIA3 protein disulfide isomerase family A, member 3 -0.0315485
ASPH aspartate beta-hydroxylase -0.0311087
RCOR1 REST corepressor 1 -0.0310589
SEC61G Sec61 gamma subunit -0.0301969
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.03005
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0299905
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0297204
AGR2 anterior gradient 2 -0.0289598
S100A10 S100 calcium binding protein A10 -0.0281495
TRAF3 TNF receptor-associated factor 3 -0.028107
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0279163
ANKRD12 ankyrin repeat domain 12 -0.0278966
NRIP1 nuclear receptor interacting protein 1 -0.0275042
MSN moesin -0.0273115
CAV1 caveolin 1, caveolae protein, 22kDa -0.0269164
PFN1 profilin 1 -0.0252359
RPS6 ribosomal protein S6 -0.0252259
BIRC3 baculoviral IAP repeat containing 3 -0.0245903
RIN2 Ras and Rab interactor 2 -0.0245297
MYO1E myosin IE -0.0244899
LIMCH1 LIM and calponin homology domains 1 -0.0243277
ACTG1 actin gamma 1 -0.023914
KRT19 keratin 19, type I -0.0238752
CCND1 cyclin D1 -0.0236585
CATSPERB catsper channel auxiliary subunit beta -0.023224
MYO1D myosin ID -0.0231745
S100A11 S100 calcium binding protein A11 -0.0229575
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0229332
AKAP13 A kinase (PRKA) anchor protein 13 -0.0228936
SPIRE1 spire-type actin nucleation factor 1 -0.0226546
CCSER1 coiled-coil serine-rich protein 1 -0.0225183
MAGEA4 melanoma antigen family A4 -0.0224836
PLS3 plastin 3 -0.0223241
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0218078
MAML2 mastermind-like 2 (Drosophila) -0.0217854
TAPBP TAP binding protein (tapasin) -0.0208162
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0207471
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0204589
ITGA6 integrin, alpha 6 -0.0201414
KRT8 keratin 8, type II -0.0198708
IFI27 interferon, alpha-inducible protein 27 -0.0198302
S100A6 S100 calcium binding protein A6 -0.0197801
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0197737
FLNB filamin B, beta -0.0195814
SPTSSA serine palmitoyltransferase, small subunit A -0.0195361
ZNF609 zinc finger protein 609 -0.0195356
AKR1C1 aldo-keto reductase family 1, member C1 -0.0194121
TMEM165 transmembrane protein 165 -0.019352
MGST1 microsomal glutathione S-transferase 1 -0.0193308
CLDN7 claudin 7 -0.0192651
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0192639
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.019179
ADAM32 ADAM metallopeptidase domain 32 -0.0190594
LAMA5 laminin, alpha 5 -0.0190251
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0187873
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0186925
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0183373
EGR1 early growth response 1 -0.0182649
CMIP c-Maf inducing protein -0.0180844
HOMER1 homer scaffolding protein 1 -0.0179266
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0178911
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0176628
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0176295
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0175303
IGFBP3 insulin-like growth factor binding protein 3 -0.0174728
HMGA1 high mobility group AT-hook 1 -0.0174175
ADIPOR2 adiponectin receptor 2 -0.0174154
RAP2B RAP2B, member of RAS oncogene family -0.017388
VEGFA vascular endothelial growth factor A -0.0173543
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0172754
STC2 stanniocalcin 2 -0.0171645
PTEN phosphatase and tensin homolog -0.017085
HM13 histocompatibility (minor) 13 -0.0170375
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0169869
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0168823