Rapamycin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rapamycin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM20C family with sequence similarity 20, member C 0.0894703
GRB10 growth factor receptor-bound protein 10 0.0804906
VEGFA vascular endothelial growth factor A 0.0747182
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0739248
NAV2 neuron navigator 2 0.071705
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0684982
SMAD3 SMAD family member 3 0.0648059
AKAP12 A kinase (PRKA) anchor protein 12 0.0628705
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0602508
TRIO trio Rho guanine nucleotide exchange factor 0.0561537
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0517887
EEF2 eukaryotic translation elongation factor 2 0.0459917
SDK1 sidekick cell adhesion molecule 1 0.0444842
COL7A1 collagen, type VII, alpha 1 0.043586
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0435613
EFNA5 ephrin-A5 0.0392274
FTH1 ferritin, heavy polypeptide 1 0.0388675
ANGPTL4 angiopoietin-like 4 0.0384828
EGFR epidermal growth factor receptor 0.038167
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0371971
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0363306
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0346984
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0343643
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.033526
PCBP2 poly(rC) binding protein 2 0.0331424
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0320086
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0318305
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0307826
SEPTIN9 septin 9 0.0297543
LOXL2 lysyl oxidase-like 2 0.0284768
PTK2 protein tyrosine kinase 2 0.028031
SHB Src homology 2 domain containing adaptor protein B 0.0267964
SOD2 superoxide dismutase 2, mitochondrial 0.0258013
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0255736
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0249159
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0248876
MYH9 myosin, heavy chain 9, non-muscle 0.0246539
RUNX1 runt-related transcription factor 1 0.0242476
KCTD16 potassium channel tetramerization domain containing 16 0.0239195
MTSS1 metastasis suppressor 1 0.0235558
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0235342
PLEC plectin 0.0233929
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.023086
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0229699
RARB retinoic acid receptor, beta 0.0223609
LRMDA leucine rich melanocyte differentiation associated 0.0222036
NCOR2 nuclear receptor corepressor 2 0.0218683
INTS6 integrator complex subunit 6 0.0217633
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0213895
EHBP1L1 EH domain binding protein 1-like 1 0.0213244
PRELID2 PRELI domain containing 2 0.0208177
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0207376
ANKRD36 ankyrin repeat domain 36 0.0206605
CEP250 centrosomal protein 250kDa 0.0205049
IGFBP3 insulin-like growth factor binding protein 3 0.0199323
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.019847
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0196712
EFCAB13 EF-hand calcium binding domain 13 0.0194275
HSPA8 heat shock 70kDa protein 8 0.0190524
IFI44L interferon-induced protein 44-like 0.0190179
ZNF638 zinc finger protein 638 0.0189972
FAM13A family with sequence similarity 13, member A 0.0188966
TGM2 transglutaminase 2 0.0188874
TAC4 tachykinin 4 (hemokinin) 0.0188698
FAM219A family with sequence similarity 219, member A 0.0186394
IGF1R insulin-like growth factor 1 receptor 0.0183626
BIRC3 baculoviral IAP repeat containing 3 0.0183413
NAV1 neuron navigator 1 0.0177741
AMPD3 adenosine monophosphate deaminase 3 0.0177609
RPL13A ribosomal protein L13a 0.0177292
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.017705
NFE2L1 nuclear factor, erythroid 2-like 1 0.0176083
MYO10 myosin X 0.0175842
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0175254
DOCK5 dedicator of cytokinesis 5 0.0173949
ZMIZ1 zinc finger, MIZ-type containing 1 0.0173277
IRAK2 interleukin-1 receptor-associated kinase 2 0.0172728
NEBL nebulette 0.0170811
SKIL SKI-like proto-oncogene 0.0170697
GYS1 glycogen synthase 1 (muscle) 0.0168392
PODXL podocalyxin-like 0.0166858
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0166482
CTBP2 C-terminal binding protein 2 0.016574
ECE1 endothelin converting enzyme 1 0.0164907
EIF4B eukaryotic translation initiation factor 4B 0.0163974
NOTCH2 notch 2 0.0163202
TPM1 tropomyosin 1 (alpha) 0.0162134
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0161974
TNS1 tensin 1 0.0161583
ANKH ANKH inorganic pyrophosphate transport regulator 0.0159984
SKAP2 src kinase associated phosphoprotein 2 0.0158051
RNF213 ring finger protein 213 0.0156755
MAML3 mastermind-like 3 (Drosophila) 0.0154364
TPST1 tyrosylprotein sulfotransferase 1 0.0153916
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0151753
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0151319
AUTS2 autism susceptibility candidate 2 0.0151218
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0151008
ZNF469 zinc finger protein 469 0.0150004
ADAM19 ADAM metallopeptidase domain 19 0.0149892

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230832
TMSB10 thymosin beta 10 -0.22071
VIM vimentin -0.169451
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.125512
CD44 CD44 molecule (Indian blood group) -0.110491
GLCCI1 glucocorticoid induced 1 -0.108619
NAMPT nicotinamide phosphoribosyltransferase -0.101769
STC1 stanniocalcin 1 -0.0905734
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0883438
OSMR oncostatin M receptor -0.0861734
S100A6 S100 calcium binding protein A6 -0.0850247
PTMA prothymosin, alpha -0.07534
FTL ferritin, light polypeptide -0.0748298
LOX lysyl oxidase -0.0746458
TFPI2 tissue factor pathway inhibitor 2 -0.0729925
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0719761
DPYD dihydropyrimidine dehydrogenase -0.070371
PDE4D phosphodiesterase 4D, cAMP-specific -0.0693256
RAB1A RAB1A, member RAS oncogene family -0.0681908
ZMYND8 zinc finger, MYND-type containing 8 -0.0648479
FN1 fibronectin 1 -0.0609935
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0586211
RICTOR RPTOR independent companion of MTOR, complex 2 -0.056083
TM4SF1 transmembrane 4 L six family member 1 -0.0557605
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0552145
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0549045
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0521404
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0515007
B2M beta-2-microglobulin -0.0500578
WSB1 WD repeat and SOCS box containing 1 -0.0495928
ARHGAP5 Rho GTPase activating protein 5 -0.0479766
RAP1B RAP1B, member of RAS oncogene family -0.0466064
RBM39 RNA binding motif protein 39 -0.0463405
LMAN1 lectin, mannose-binding, 1 -0.045114
VRK2 vaccinia related kinase 2 -0.0450218
EGR1 early growth response 1 -0.0444027
ANKRD28 ankyrin repeat domain 28 -0.0442425
TNNC1 troponin C type 1 (slow) -0.0438364
TPT1 tumor protein, translationally-controlled 1 -0.0424129
EIF1 eukaryotic translation initiation factor 1 -0.0420195
S100A10 S100 calcium binding protein A10 -0.0415137
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0413876
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0413106
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0405128
USP34 ubiquitin specific peptidase 34 -0.0396826
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0396517
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0388625
RPS21 ribosomal protein S21 -0.0383345
IFI16 interferon, gamma-inducible protein 16 -0.0381788
GOLGA4 golgin A4 -0.037787
IER3 immediate early response 3 -0.0374567
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0369406
NF1 neurofibromin 1 -0.0365534
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0365005
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0361539
NTN4 netrin 4 -0.0358737
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0341241
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0338583
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0337289
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0336199
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0334963
BTG1 B-cell translocation gene 1, anti-proliferative -0.0331424
ZEB2 zinc finger E-box binding homeobox 2 -0.0331353
RPL35A ribosomal protein L35a -0.0329331
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0316422
NPC1 Niemann-Pick disease, type C1 -0.0316393
LOC102724023 ES1 protein homolog, mitochondrial -0.031624
RAB27B RAB27B, member RAS oncogene family -0.0313107
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0313037
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0312258
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0309207
SEC31A SEC31 homolog A (S. cerevisiae) -0.030896
RNF24 ring finger protein 24 -0.0307012
IFI6 interferon, alpha-inducible protein 6 -0.0306526
GCC2 GRIP and coiled-coil domain containing 2 -0.030449
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0300322
TMEM263 transmembrane protein 263 -0.029966
PRRC2C proline-rich coiled-coil 2C -0.0296496
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0296081
SNX9 sorting nexin 9 -0.0295316
HLA-B major histocompatibility complex, class I, B -0.0295016
ARL4C ADP-ribosylation factor-like 4C -0.0292904
DENND4A DENN/MADD domain containing 4A -0.0292103
ANKRD12 ankyrin repeat domain 12 -0.0289943
KDM3A lysine (K)-specific demethylase 3A -0.0289304
KDM2A lysine (K)-specific demethylase 2A -0.028264
TMEM131 transmembrane protein 131 -0.0282391
THBD thrombomodulin -0.0281227
POTEF POTE ankyrin domain family, member F -0.0280238
RPL34 ribosomal protein L34 -0.0278964
H1-0 H1.0 linker histone -0.0278919
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0278792
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0276936
RAB5A RAB5A, member RAS oncogene family -0.0274803
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0274452
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.027289
SOS2 son of sevenless homolog 2 (Drosophila) -0.0272662
DDIT3 DNA-damage-inducible transcript 3 -0.0272409
NUMB numb homolog (Drosophila) -0.0270454
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0269994