Rapamycin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.220171
GRAMD1B GRAM domain containing 1B 0.147108
THSD4 thrombospondin, type I, domain containing 4 0.100602
ERRFI1 ERBB receptor feedback inhibitor 1 0.0837442
IGF1R insulin-like growth factor 1 receptor 0.0837067
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0828877
TXNRD1 thioredoxin reductase 1 0.070416
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0655384
TRIO trio Rho guanine nucleotide exchange factor 0.0596915
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0572827
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0564644
RAD51B RAD51 paralog B 0.05543
EXOC4 exocyst complex component 4 0.0550752
MCL1 myeloid cell leukemia 1 0.0547927
PDE4D phosphodiesterase 4D, cAMP-specific 0.05474
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0544634
ATP11A ATPase, class VI, type 11A 0.0537384
OSMR oncostatin M receptor 0.0533741
PTK2 protein tyrosine kinase 2 0.052654
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0519768
ZFAND3 zinc finger, AN1-type domain 3 0.051952
FMNL2 formin-like 2 0.0500556
PDE10A phosphodiesterase 10A 0.0496804
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0491421
DOCK5 dedicator of cytokinesis 5 0.0490928
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0475531
MACF1 microtubule-actin crosslinking factor 1 0.0472427
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0468524
EXT1 exostosin glycosyltransferase 1 0.0454194
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0435059
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0431291
TAS2R14 taste receptor, type 2, member 14 0.0414432
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0409992
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0409889
USP34 ubiquitin specific peptidase 34 0.0407761
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0407269
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0394312
AFF3 AF4/FMR2 family, member 3 0.0393423
YBX3 Y box binding protein 3 0.039144
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0386095
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0383038
NF1 neurofibromin 1 0.0382394
ANO6 anoctamin 6 0.0380581
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0376212
SMAD3 SMAD family member 3 0.037308
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0370728
RIMS2 regulating synaptic membrane exocytosis 2 0.0368813
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0354681
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0354614
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0345788
PRKCE protein kinase C, epsilon 0.0344306
ELL2 elongation factor, RNA polymerase II, 2 0.0339562
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0338306
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0336701
ZNF638 zinc finger protein 638 0.0326027
ATXN1 ataxin 1 0.0322167
SVIL supervillin 0.0318136
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0312657
DENND5B DENN/MADD domain containing 5B 0.0312427
DST dystonin 0.0307976
EGFR epidermal growth factor receptor 0.030752
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0304877
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0303861
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0303167
HMGA2 high mobility group AT-hook 2 0.0303053
SMYD3 SET and MYND domain containing 3 0.0297041
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0295778
PDLIM5 PDZ and LIM domain 5 0.0289777
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0280206
ACTN1 actinin, alpha 1 0.0278999
SPIDR scaffolding protein involved in DNA repair 0.0278259
DOCK1 dedicator of cytokinesis 1 0.027792
RABGAP1L RAB GTPase activating protein 1-like 0.0277743
VCL vinculin 0.0273998
MYH9 myosin, heavy chain 9, non-muscle 0.0273377
LOXL2 lysyl oxidase-like 2 0.0272569
CUX1 cut-like homeobox 1 0.0269906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0267434
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0266629
DNAH14 dynein, axonemal, heavy chain 14 0.0262285
ZBTB20 zinc finger and BTB domain containing 20 0.0260181
PMEPA1 prostate transmembrane protein, androgen induced 1 0.025896
ZCCHC7 zinc finger, CCHC domain containing 7 0.0257813
ZSWIM6 zinc finger, SWIM-type containing 6 0.0252649
CMIP c-Maf inducing protein 0.0251845
EXOC6B exocyst complex component 6B 0.0250408
SHB Src homology 2 domain containing adaptor protein B 0.0249412
RBM39 RNA binding motif protein 39 0.0248907
TRIP12 thyroid hormone receptor interactor 12 0.0248901
RAB7A RAB7A, member RAS oncogene family 0.0248215
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0247832
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0245894
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0245497
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0245219
SFPQ splicing factor proline/glutamine-rich 0.0244467
WDR70 WD repeat domain 70 0.0244091
RICTOR RPTOR independent companion of MTOR, complex 2 0.0243934
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0242387
YAP1 Yes-associated protein 1 0.0241618
DENND1A DENN/MADD domain containing 1A 0.0241484

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22344
TMSB10 thymosin beta 10 -0.0894718
PTMA prothymosin, alpha -0.0769006
VIM vimentin -0.0750234
RPS3 ribosomal protein S3 -0.0565989
RPS8 ribosomal protein S8 -0.0530737
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0519348
RPL37A ribosomal protein L37a -0.0497594
MT2A metallothionein 2A -0.0466125
RPL37 ribosomal protein L37 -0.044354
TPT1 tumor protein, translationally-controlled 1 -0.0434935
RPL12 ribosomal protein L12 -0.0432104
RPL26 ribosomal protein L26 -0.0432002
TPI1 triosephosphate isomerase 1 -0.0414622
RPL35A ribosomal protein L35a -0.0399423
RPLP0 ribosomal protein, large, P0 -0.0381151
RPL23 ribosomal protein L23 -0.0380933
RPLP1 ribosomal protein, large, P1 -0.0378421
RPS12 ribosomal protein S12 -0.0374268
FTL ferritin, light polypeptide -0.0357386
MYL12B myosin, light chain 12B, regulatory -0.0353929
RPS27 ribosomal protein S27 -0.0347198
RPS19 ribosomal protein S19 -0.0344277
RPS6 ribosomal protein S6 -0.0333282
RPS21 ribosomal protein S21 -0.032531
PFN1 profilin 1 -0.0319238
RPL31 ribosomal protein L31 -0.0312994
RPL9 ribosomal protein L9 -0.0300916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029984
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0297517
RPL36 ribosomal protein L36 -0.0278623
RPL34 ribosomal protein L34 -0.0277333
RPS29 ribosomal protein S29 -0.0275657
RPL19 ribosomal protein L19 -0.0272527
RPS15 ribosomal protein S15 -0.0266661
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0265394
RPLP2 ribosomal protein, large, P2 -0.026241
RPL11 ribosomal protein L11 -0.0261361
RPS27A ribosomal protein S27a -0.0252347
IFI6 interferon, alpha-inducible protein 6 -0.0246502
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0237848
RPS4X ribosomal protein S4, X-linked -0.0229454
RPS24 ribosomal protein S24 -0.0227417
RPL32 ribosomal protein L32 -0.0224993
RPS25 ribosomal protein S25 -0.0224173
RPS17 ribosomal protein S17 -0.0222404
NACA nascent polypeptide-associated complex alpha subunit -0.0217309
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0212557
HLA-B major histocompatibility complex, class I, B -0.0212401
RPL5 ribosomal protein L5 -0.0212379
RPL36A ribosomal protein L36a -0.02113
RPL8 ribosomal protein L8 -0.0209229
EIF1 eukaryotic translation initiation factor 1 -0.0206682
RPS10 ribosomal protein S10 -0.0201536
YBX1 Y box binding protein 1 -0.0201182
RACK1 receptor for activated C kinase 1 -0.0195352
RPS13 ribosomal protein S13 -0.0194033
ATP5F1E ATP synthase F1 subunit epsilon -0.0186289
RPS23 ribosomal protein S23 -0.0184315
LDHB lactate dehydrogenase B -0.0179815
RPS14 ribosomal protein S14 -0.0179323
RPL35 ribosomal protein L35 -0.0178553
S100A6 S100 calcium binding protein A6 -0.0175782
HMGA1 high mobility group AT-hook 1 -0.0174112
TFPI2 tissue factor pathway inhibitor 2 -0.0173704
EIF5B eukaryotic translation initiation factor 5B -0.0173303
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0172775
RPL7A ribosomal protein L7a -0.0172302
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0171887
RPL18 ribosomal protein L18 -0.0169703
RPL28 ribosomal protein L28 -0.0168157
SEPTIN7 septin 7 -0.0166323
VDAC1 voltage-dependent anion channel 1 -0.0165492
TUBA1B tubulin, alpha 1b -0.0158247
SMC4 structural maintenance of chromosomes 4 -0.015737
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0155582
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0155461
TPM2 tropomyosin 2 (beta) -0.0151929
RPL27 ribosomal protein L27 -0.0151733
B2M beta-2-microglobulin -0.0148536
RPL15 ribosomal protein L15 -0.0148448
ATP5F1B ATP synthase F1 subunit beta -0.0148182
DEK DEK proto-oncogene -0.0143894
RPS16 ribosomal protein S16 -0.0142787
GSTP1 glutathione S-transferase pi 1 -0.0142422
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.014154
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.014056
EGR1 early growth response 1 -0.0136837
SSB Sjogren syndrome antigen B (autoantigen La) -0.013617
RPL13A ribosomal protein L13a -0.0135539
NOP58 NOP58 ribonucleoprotein -0.0134292
H3-3B H3.3 histone B -0.0128551
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0127514
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0126881
RPL21 ribosomal protein L21 -0.0126656
TUBA1C tubulin, alpha 1c -0.0126199
CBX3 chromobox homolog 3 -0.0125514
KPNB1 karyopherin (importin) beta 1 -0.0121961
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0121224
RPL30 ribosomal protein L30 -0.012111