Rapamycin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.08388
ZFAND3 zinc finger, AN1-type domain 3 0.0802907
TSC22D2 TSC22 domain family, member 2 0.0735681
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0648552
PLPP1 phospholipid phosphatase 1 0.060016
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0573953
PGAP1 post-GPI attachment to proteins 1 0.0551128
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0542414
FNDC3B fibronectin type III domain containing 3B 0.0542244
FBXO11 F-box protein 11 0.0472686
PHIP pleckstrin homology domain interacting protein 0.0457879
STRN3 striatin, calmodulin binding protein 3 0.0436351
KDM2A lysine (K)-specific demethylase 2A 0.0427464
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0425558
COG5 component of oligomeric golgi complex 5 0.0419014
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0400444
TRIO trio Rho guanine nucleotide exchange factor 0.0386575
APP amyloid beta (A4) precursor protein 0.0378478
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0370703
ATRN attractin 0.0358623
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.035135
NEBL nebulette 0.0350851
GMDS GDP-mannose 4,6-dehydratase 0.034101
PHF3 PHD finger protein 3 0.0337066
PICALM phosphatidylinositol binding clathrin assembly protein 0.0336282
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0332345
ANKRD33B ankyrin repeat domain 33B 0.0332212
MED13L mediator complex subunit 13-like 0.0328582
WWC2 WW and C2 domain containing 2 0.0322975
FAT1 FAT atypical cadherin 1 0.0322607
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0321107
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0318648
SRPK2 SRSF protein kinase 2 0.0318482
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0311021
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0309113
GARS1 glycyl-tRNA synthetase 1 0.0307137
UBE3C ubiquitin protein ligase E3C 0.0299719
ENAH enabled homolog (Drosophila) 0.0293072
ZSWIM6 zinc finger, SWIM-type containing 6 0.0292551
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0291521
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.02904
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0285017
HDAC9 histone deacetylase 9 0.0284498
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0281674
EEF2 eukaryotic translation elongation factor 2 0.0280185
RAB7A RAB7A, member RAS oncogene family 0.0276554
CTBP2 C-terminal binding protein 2 0.0272883
DENND4A DENN/MADD domain containing 4A 0.0272519
SAMD4A sterile alpha motif domain containing 4A 0.0272171
SBF2 SET binding factor 2 0.0271793
MAP4 microtubule-associated protein 4 0.0267274
AKAP13 A kinase (PRKA) anchor protein 13 0.026654
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0265068
CHD7 chromodomain helicase DNA binding protein 7 0.0262367
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0260689
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0259166
BRWD1 bromodomain and WD repeat domain containing 1 0.0257366
ARHGAP21 Rho GTPase activating protein 21 0.0254386
UTRN utrophin 0.0254343
MYH9 myosin, heavy chain 9, non-muscle 0.0253867
KMT2C lysine (K)-specific methyltransferase 2C 0.0249729
SMYD3 SET and MYND domain containing 3 0.0249218
NXN nucleoredoxin 0.0247507
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0244746
PUM2 pumilio RNA-binding family member 2 0.0241655
LYST lysosomal trafficking regulator 0.0241307
ITCH itchy E3 ubiquitin protein ligase 0.0240979
CDC73 cell division cycle 73 0.0239891
CDK13 cyclin-dependent kinase 13 0.0239873
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0238963
NCOR2 nuclear receptor corepressor 2 0.0238241
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0238092
USP3 ubiquitin specific peptidase 3 0.023114
ARID1A AT rich interactive domain 1A (SWI-like) 0.0229902
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0227433
EGFR epidermal growth factor receptor 0.0225945
DIDO1 death inducer-obliterator 1 0.02252
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0224652
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0224304
KMT2E lysine (K)-specific methyltransferase 2E 0.0223912
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0223526
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0223123
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0221182
KLC1 kinesin light chain 1 0.0220532
ZNF638 zinc finger protein 638 0.0219426
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0217715
USP25 ubiquitin specific peptidase 25 0.0217471
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0217118
MTF2 metal response element binding transcription factor 2 0.0216161
TBC1D22A TBC1 domain family, member 22A 0.0216107
DST dystonin 0.0215846
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0215539
FAM168A family with sequence similarity 168, member A 0.0215517
SCAF4 SR-related CTD-associated factor 4 0.0215286
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.0214802
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0213755
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0210788
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0209315
PRTG protogenin 0.0206807
WAC WW domain containing adaptor with coiled-coil 0.020634

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.177541
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.146797
VIM vimentin -0.137415
PCDH9 protocadherin 9 -0.135852
COL3A1 collagen, type III, alpha 1 -0.113698
ADGRL2 adhesion G protein-coupled receptor L2 -0.0958473
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0817089
GPC3 glypican 3 -0.0813641
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0738226
TMSB10 thymosin beta 10 -0.0736512
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0695629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0688613
MKI67 marker of proliferation Ki-67 -0.0643559
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0592334
TPT1 tumor protein, translationally-controlled 1 -0.0589232
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0587325
MDK midkine (neurite growth-promoting factor 2) -0.0561839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0544883
GNAS GNAS complex locus -0.0544847
RPS8 ribosomal protein S8 -0.0540365
RPS16 ribosomal protein S16 -0.0523912
ADGRV1 adhesion G protein-coupled receptor V1 -0.0521436
LRRC4C leucine rich repeat containing 4C -0.0489057
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0485394
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0483205
COL11A1 collagen, type XI, alpha 1 -0.0478643
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0452605
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0446538
ACTG1 actin gamma 1 -0.0442286
FOXP2 forkhead box P2 -0.0439087
RPLP0 ribosomal protein, large, P0 -0.0408658
H1-0 H1.0 linker histone -0.0401271
PROS1 protein S (alpha) -0.0397902
RPLP1 ribosomal protein, large, P1 -0.0397477
RPS6 ribosomal protein S6 -0.038891
MPG N-methylpurine-DNA glycosylase -0.0382901
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0382295
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0379911
RPS24 ribosomal protein S24 -0.0376773
KDM3A lysine (K)-specific demethylase 3A -0.0374383
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0368929
FST follistatin -0.0367205
RPL34 ribosomal protein L34 -0.0362423
COL1A2 collagen, type I, alpha 2 -0.0354431
AHNAK AHNAK nucleoprotein -0.0350798
COL5A2 collagen, type V, alpha 2 -0.0349508
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0348837
ENO1 enolase 1, (alpha) -0.0347982
SFRP4 secreted frizzled-related protein 4 -0.0340429
TMSB4X thymosin beta 4, X-linked -0.0339252
RPS21 ribosomal protein S21 -0.0334858
RPS12 ribosomal protein S12 -0.0334798
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0334422
PCLO piccolo presynaptic cytomatrix protein -0.0332498
RPL26 ribosomal protein L26 -0.0332447
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0330396
RPL35A ribosomal protein L35a -0.032692
RPL37 ribosomal protein L37 -0.0326668
CALR calreticulin -0.0325387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0321932
RPL11 ribosomal protein L11 -0.0318194
GREB1L growth regulation by estrogen in breast cancer-like -0.0317567
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.031621
DEK DEK proto-oncogene -0.0313184
HMCN1 hemicentin 1 -0.0313063
FTL ferritin, light polypeptide -0.0310352
RPL19 ribosomal protein L19 -0.0310157
HMGB1 high mobility group box 1 -0.0306094
PCDH7 protocadherin 7 -0.0302148
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0300261
TUBA1B tubulin, alpha 1b -0.0298744
ARHGAP15 Rho GTPase activating protein 15 -0.0295243
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.029149
TUBB tubulin, beta class I -0.0289624
B2M beta-2-microglobulin -0.02809
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280659
HMGB2 high mobility group box 2 -0.0278009
RPS19 ribosomal protein S19 -0.0275716
MYL12B myosin, light chain 12B, regulatory -0.0265844
SOX2 SRY (sex determining region Y)-box 2 -0.0264502
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0262699
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0262569
MED12L mediator complex subunit 12-like -0.0260539
MEIS2 Meis homeobox 2 -0.026047
ZNF385D zinc finger protein 385D -0.0260016
RPL31 ribosomal protein L31 -0.02597
PDE4D phosphodiesterase 4D, cAMP-specific -0.0256822
KCTD16 potassium channel tetramerization domain containing 16 -0.0255193
NRG1 neuregulin 1 -0.0254235
MACROD2 MACRO domain containing 2 -0.025391
AKAP12 A kinase (PRKA) anchor protein 12 -0.0249632
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.024806
NCAM2 neural cell adhesion molecule 2 -0.0242989
NF1 neurofibromin 1 -0.0240519
PARD3B par-3 family cell polarity regulator beta -0.0240505
RPL18 ribosomal protein L18 -0.0236814
SOX5 SRY (sex determining region Y)-box 5 -0.0236513
NAMPT nicotinamide phosphoribosyltransferase -0.0234692
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0233975
PRELID2 PRELI domain containing 2 -0.0232932