Rapamycin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0717914
TXNRD1 thioredoxin reductase 1 0.0589788
TJP1 tight junction protein 1 0.0439785
EZR ezrin 0.040215
FLNB filamin B, beta 0.0373245
ZNF608 zinc finger protein 608 0.0356882
ECT2 epithelial cell transforming 2 0.0354028
EGFR epidermal growth factor receptor 0.0313248
ZBTB20 zinc finger and BTB domain containing 20 0.0311083
GOLGA4 golgin A4 0.0301837
SOX6 SRY (sex determining region Y)-box 6 0.0295422
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0294979
ADAM10 ADAM metallopeptidase domain 10 0.0286505
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0280231
TTC3 tetratricopeptide repeat domain 3 0.0272257
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0270446
CCNL1 cyclin L1 0.0266872
GARS1 glycyl-tRNA synthetase 1 0.0258774
PDGFC platelet derived growth factor C 0.0254742
BRWD1 bromodomain and WD repeat domain containing 1 0.0249284
ANK2 ankyrin 2, neuronal 0.023928
RTN4 reticulon 4 0.0234015
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230015
NUP58 nucleoporin 58 0.0227752
TMEM65 transmembrane protein 65 0.0222356
PNISR PNN-interacting serine/arginine-rich protein 0.0221257
LOC112694756 uncharaterized LOC112694756 0.0218616
TBC1D5 TBC1 domain family, member 5 0.0217134
NCKAP1 NCK-associated protein 1 0.0217096
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0216005
RNF145 ring finger protein 145 0.0209368
METTL15 methyltransferase like 15 0.020535
ZNF292 zinc finger protein 292 0.02051
PRELID2 PRELI domain containing 2 0.0204401
IARS1 isoleucyl-tRNA synthetase 1 0.0204136
DPYD dihydropyrimidine dehydrogenase 0.0201662
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0194868
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0193259
TGFBR3 transforming growth factor, beta receptor III 0.0187404
GLI2 GLI family zinc finger 2 0.0185367
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018403
NBAS neuroblastoma amplified sequence 0.018152
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0181109
BMP2K BMP2 inducible kinase 0.0180634
AKAP9 A kinase (PRKA) anchor protein 9 0.017653
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0175814
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0175526
HDAC9 histone deacetylase 9 0.0174747
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0172823
NCEH1 neutral cholesterol ester hydrolase 1 0.0172758
CDC73 cell division cycle 73 0.0170889
PLK2 polo-like kinase 2 0.0170289
RAB27B RAB27B, member RAS oncogene family 0.0168468
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0168225
SMYD3 SET and MYND domain containing 3 0.0167364
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0166515
ARRDC3 arrestin domain containing 3 0.0159952
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0159501
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0159234
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0158048
SPRED2 sprouty-related, EVH1 domain containing 2 0.0157551
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0154285
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0153809
ZMYM2 zinc finger, MYM-type 2 0.0153232
ARB2A ARB2 cotranscriptional regulator A 0.0151891
ITGA6 integrin, alpha 6 0.0149111
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0147503
PCGF5 polycomb group ring finger 5 0.0147047
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0146004
ZNF638 zinc finger protein 638 0.0145466
GSK3B glycogen synthase kinase 3 beta 0.0144044
FCHSD2 FCH and double SH3 domains 2 0.0143778
SPRY4 sprouty homolog 4 (Drosophila) 0.0143596
NAMPT nicotinamide phosphoribosyltransferase 0.0141496
PCBP2 poly(rC) binding protein 2 0.0140967
KLF3 Kruppel-like factor 3 (basic) 0.0139803
PTBP2 polypyrimidine tract binding protein 2 0.0137966
MACF1 microtubule-actin crosslinking factor 1 0.0137569
USP34 ubiquitin specific peptidase 34 0.0137516
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0137361
MBD5 methyl-CpG binding domain protein 5 0.0136214
LDHA lactate dehydrogenase A 0.0136013
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0134186
ADAM9 ADAM metallopeptidase domain 9 0.0134168
COG6 component of oligomeric golgi complex 6 0.0133544
ZBTB38 zinc finger and BTB domain containing 38 0.0133139
USP24 ubiquitin specific peptidase 24 0.0131258
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0131149
CCDC68 coiled-coil domain containing 68 0.0129442
TNRC6B trinucleotide repeat containing 6B 0.0128897
PAQR3 progestin and adipoQ receptor family member III 0.0128668
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0125033
DSCAM Down syndrome cell adhesion molecule 0.0123929
TXNIP thioredoxin interacting protein 0.0123801
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0123328
DOCK3 dedicator of cytokinesis 3 0.0122959
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0122786
QKI QKI, KH domain containing, RNA binding 0.0121133
ZFC3H1 zinc finger, C3H1-type containing 0.0120944
FAM91A1 family with sequence similarity 91, member A1 0.0118148

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.336715
RPS6 ribosomal protein S6 -0.0994004
TPT1 tumor protein, translationally-controlled 1 -0.0944809
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0928528
BMP10 bone morphogenetic protein 10 -0.0756769
RPL35A ribosomal protein L35a -0.0751165
RPS8 ribosomal protein S8 -0.0734326
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0729881
RPL31 ribosomal protein L31 -0.0672091
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0670087
RPL34 ribosomal protein L34 -0.0619235
FOXP1 forkhead box P1 -0.0537351
RPLP1 ribosomal protein, large, P1 -0.0536313
RPS13 ribosomal protein S13 -0.051423
RPS25 ribosomal protein S25 -0.0460514
RPL19 ribosomal protein L19 -0.0458429
RPS27A ribosomal protein S27a -0.0444511
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0440041
RPS23 ribosomal protein S23 -0.0422489
RPS3 ribosomal protein S3 -0.0421751
RPL26 ribosomal protein L26 -0.0420303
RPL37A ribosomal protein L37a -0.0420232
RPL9 ribosomal protein L9 -0.0402387
KPNB1 karyopherin (importin) beta 1 -0.0392348
RPLP2 ribosomal protein, large, P2 -0.0374185
RPS29 ribosomal protein S29 -0.0344889
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0344402
HSPB1 heat shock 27kDa protein 1 -0.0339172
RPL30 ribosomal protein L30 -0.0326106
RPS24 ribosomal protein S24 -0.0325356
AHNAK AHNAK nucleoprotein -0.0324632
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0319639
RPL23 ribosomal protein L23 -0.0316988
RPL38 ribosomal protein L38 -0.0309567
RPS27 ribosomal protein S27 -0.0308439
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0307392
EBNA1BP2 EBNA1 binding protein 2 -0.0305284
DLG1 discs, large homolog 1 (Drosophila) -0.0303742
S100A9 S100 calcium binding protein A9 -0.0296551
MYL12B myosin, light chain 12B, regulatory -0.0294767
RPS19 ribosomal protein S19 -0.0291892
RPL8 ribosomal protein L8 -0.0286068
FNDC3B fibronectin type III domain containing 3B -0.0280831
VCL vinculin -0.0277788
RPL37 ribosomal protein L37 -0.0277697
MKI67 marker of proliferation Ki-67 -0.0274982
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0268967
RPL7A ribosomal protein L7a -0.0264372
EIF1 eukaryotic translation initiation factor 1 -0.0261211
WSB1 WD repeat and SOCS box containing 1 -0.0258893
TM4SF1 transmembrane 4 L six family member 1 -0.025682
SEPTIN9 septin 9 -0.0253129
NOP56 NOP56 ribonucleoprotein -0.0251227
PDE4B phosphodiesterase 4B, cAMP-specific -0.0250668
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0246695
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0245868
RPS21 ribosomal protein S21 -0.0244292
NAP1L1 nucleosome assembly protein 1-like 1 -0.0243922
ENO2 enolase 2 (gamma, neuronal) -0.0242917
LOC102724023 ES1 protein homolog, mitochondrial -0.0241398
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.023739
ASPH aspartate beta-hydroxylase -0.0237097
TUBB4B tubulin, beta 4B class IVb -0.0233377
RPL10A ribosomal protein L10a -0.0232909
ANKRD17 ankyrin repeat domain 17 -0.0232441
RPL36A ribosomal protein L36a -0.0221264
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0220494
HLA-B major histocompatibility complex, class I, B -0.021665
NEBL nebulette -0.0216558
RACK1 receptor for activated C kinase 1 -0.0216098
RPL36 ribosomal protein L36 -0.0212229
RPL13A ribosomal protein L13a -0.0211721
UNC13A unc-13 homolog A (C. elegans) -0.0208977
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0208501
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0208032
FTL ferritin, light polypeptide -0.0205346
RFC3 replication factor C (activator 1) 3, 38kDa -0.0205018
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0204346
RPL15 ribosomal protein L15 -0.0203712
RPS16 ribosomal protein S16 -0.0203463
RPL35 ribosomal protein L35 -0.0201942
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0201888
HMGB1 high mobility group box 1 -0.0198665
RPS28 ribosomal protein S28 -0.0198591
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0198259
RPS12 ribosomal protein S12 -0.0194282
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0193132
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0190221
SMC4 structural maintenance of chromosomes 4 -0.0189945
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0189579
MYOF myoferlin -0.01891
IFITM3 interferon induced transmembrane protein 3 -0.0188193
RPL27A ribosomal protein L27a -0.0188082
CCND1 cyclin D1 -0.0187942
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0185626
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0185373
TUBA1B tubulin, alpha 1b -0.0185122
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0184901
ITGA10 integrin, alpha 10 -0.018405
S100A10 S100 calcium binding protein A10 -0.0183991