Rapamycin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rapamycin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rapamycin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.115093
SMAD3 SMAD family member 3 0.069408
TRIO trio Rho guanine nucleotide exchange factor 0.0651137
HMGA2 high mobility group AT-hook 2 0.0647137
TMEM156 transmembrane protein 156 0.061258
GRB10 growth factor receptor-bound protein 10 0.0611017
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0589672
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0556366
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0546094
RICTOR RPTOR independent companion of MTOR, complex 2 0.0526159
FNDC3B fibronectin type III domain containing 3B 0.0506572
SHB Src homology 2 domain containing adaptor protein B 0.0488274
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0460537
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0460534
EXT1 exostosin glycosyltransferase 1 0.0459175
MYH9 myosin, heavy chain 9, non-muscle 0.0454679
CXCL8 chemokine (C-X-C motif) ligand 8 0.0451794
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0450347
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0450227
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0448776
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0448776
FAT1 FAT atypical cadherin 1 0.0447748
VEGFA vascular endothelial growth factor A 0.0434662
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0432379
RNF145 ring finger protein 145 0.042254
NRIP1 nuclear receptor interacting protein 1 0.0421692
FLNA filamin A, alpha 0.0409367
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0373324
ZSWIM6 zinc finger, SWIM-type containing 6 0.0369403
MACF1 microtubule-actin crosslinking factor 1 0.0365976
NTN4 netrin 4 0.0357575
PTK2 protein tyrosine kinase 2 0.0347666
FAM13A family with sequence similarity 13, member A 0.0331797
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0329987
APLP2 amyloid beta (A4) precursor-like protein 2 0.0328067
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0327823
SPAG9 sperm associated antigen 9 0.0324201
ELL2 elongation factor, RNA polymerase II, 2 0.0308708
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0302752
EPS8 epidermal growth factor receptor pathway substrate 8 0.0297473
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0293797
FXR1 fragile X mental retardation, autosomal homolog 1 0.0293301
LOXL2 lysyl oxidase-like 2 0.0291161
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0285699
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0279441
AHR aryl hydrocarbon receptor 0.0275412
LYST lysosomal trafficking regulator 0.0274478
KMT2E lysine (K)-specific methyltransferase 2E 0.0272718
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271251
NEK7 NIMA-related kinase 7 0.0268745
VEGFC vascular endothelial growth factor C 0.0266804
WWTR1 WW domain containing transcription regulator 1 0.026627
TGFB2 transforming growth factor, beta 2 0.0266186
NPAS2 neuronal PAS domain protein 2 0.0250682
HELZ helicase with zinc finger 0.0247341
SVIL supervillin 0.0246818
DOCK5 dedicator of cytokinesis 5 0.0246024
MBNL1 muscleblind-like splicing regulator 1 0.0245473
CDC73 cell division cycle 73 0.0243144
NPTN neuroplastin 0.0242714
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0234877
PDLIM5 PDZ and LIM domain 5 0.0234658
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0228778
PCBP2 poly(rC) binding protein 2 0.0227315
WAC WW domain containing adaptor with coiled-coil 0.0226564
PLEC plectin 0.0224621
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.022409
SEPTIN9 septin 9 0.0222521
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0217772
NRP1 neuropilin 1 0.0216885
HILPDA hypoxia inducible lipid droplet-associated 0.0215907
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.021286
RAB8B RAB8B, member RAS oncogene family 0.0209488
NUP58 nucleoporin 58 0.0208815
SPRED2 sprouty-related, EVH1 domain containing 2 0.0208605
ADAM9 ADAM metallopeptidase domain 9 0.0208096
ZMIZ1 zinc finger, MIZ-type containing 1 0.0207128
MLPH melanophilin 0.0205962
ARHGAP35 Rho GTPase activating protein 35 0.0205148
GPATCH2L G patch domain containing 2-like 0.0204422
CLIP2 CAP-GLY domain containing linker protein 2 0.0203643
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0203081
ERBIN erbb2 interacting protein 0.0202185
RASAL2 RAS protein activator like 2 0.020101
FOSL1 FOS-like antigen 1 0.0198875
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0198444
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.019812
DST dystonin 0.0197833
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0197748
ANKRD28 ankyrin repeat domain 28 0.0197131
RAB31 RAB31, member RAS oncogene family 0.0194816
BICC1 BicC family RNA binding protein 1 0.0194452
WDR26 WD repeat domain 26 0.0193749
SSBP2 single-stranded DNA binding protein 2 0.0192007
SOX9 SRY (sex determining region Y)-box 9 0.0191981
CUL3 cullin 3 0.0191889
UBA6 ubiquitin-like modifier activating enzyme 6 0.0191376
ITGA1 integrin, alpha 1 0.0189283
COPA coatomer protein complex, subunit alpha 0.0189036
EEF2 eukaryotic translation elongation factor 2 0.0186021

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.221609
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.204131
HLA-B major histocompatibility complex, class I, B -0.142436
TMSB10 thymosin beta 10 -0.139766
TPT1 tumor protein, translationally-controlled 1 -0.137529
FTL ferritin, light polypeptide -0.103904
IFI27 interferon, alpha-inducible protein 27 -0.0868149
VIM vimentin -0.0763243
NRG1 neuregulin 1 -0.0722146
ACTG1 actin gamma 1 -0.0685879
RPL35A ribosomal protein L35a -0.0666424
RPL37A ribosomal protein L37a -0.0649794
RPL31 ribosomal protein L31 -0.0643441
RPL9 ribosomal protein L9 -0.0634138
S100A6 S100 calcium binding protein A6 -0.0613892
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0610956
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0597161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0581285
RPS8 ribosomal protein S8 -0.0568071
RPS6 ribosomal protein S6 -0.0565193
RPS24 ribosomal protein S24 -0.0554808
SQSTM1 sequestosome 1 -0.0542626
IER3 immediate early response 3 -0.0540613
B2M beta-2-microglobulin -0.0524265
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0509722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0476076
SOX4 SRY (sex determining region Y)-box 4 -0.0475605
TMSB4X thymosin beta 4, X-linked -0.0463931
RPL26 ribosomal protein L26 -0.0450173
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0434126
RPLP1 ribosomal protein, large, P1 -0.0430079
RPS3 ribosomal protein S3 -0.0425179
ZMYND8 zinc finger, MYND-type containing 8 -0.0424886
RPS12 ribosomal protein S12 -0.0421842
RPS27A ribosomal protein S27a -0.0417353
RPL34 ribosomal protein L34 -0.0409327
IFI6 interferon, alpha-inducible protein 6 -0.0406087
RPS25 ribosomal protein S25 -0.0405032
RPL38 ribosomal protein L38 -0.0404866
RPS21 ribosomal protein S21 -0.0403797
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0391478
RPS23 ribosomal protein S23 -0.0390152
TAS2R14 taste receptor, type 2, member 14 -0.0386878
RPS29 ribosomal protein S29 -0.0383619
TM4SF1 transmembrane 4 L six family member 1 -0.0378532
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0374435
PDE4D phosphodiesterase 4D, cAMP-specific -0.0369438
RPL37 ribosomal protein L37 -0.0369363
MT2A metallothionein 2A -0.0363771
RPL23 ribosomal protein L23 -0.0354931
RPLP2 ribosomal protein, large, P2 -0.0352514
IFI16 interferon, gamma-inducible protein 16 -0.0347041
EGR1 early growth response 1 -0.034521
RPL12 ribosomal protein L12 -0.034429
ENO2 enolase 2 (gamma, neuronal) -0.0343277
HLA-A major histocompatibility complex, class I, A -0.0341964
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0336107
RPL19 ribosomal protein L19 -0.0333036
PLIN2 perilipin 2 -0.0332407
ENO1 enolase 1, (alpha) -0.0325191
RPS11 ribosomal protein S11 -0.0324349
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0320879
RPLP0 ribosomal protein, large, P0 -0.0315844
S100A9 S100 calcium binding protein A9 -0.0310887
LOC102724023 ES1 protein homolog, mitochondrial -0.0309845
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.030864
CANX calnexin -0.0308052
EIF5B eukaryotic translation initiation factor 5B -0.0307321
KPNB1 karyopherin (importin) beta 1 -0.0303553
GNAS GNAS complex locus -0.0295817
RPS16 ribosomal protein S16 -0.029132
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028846
CD63 CD63 molecule -0.0287424
RPS19 ribosomal protein S19 -0.0285764
RPL36A ribosomal protein L36a -0.0283035
TPI1 triosephosphate isomerase 1 -0.0278739
CEP350 centrosomal protein 350kDa -0.0277213
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0275442
SPDYA speedy/RINGO cell cycle regulator family member A -0.0273924
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0271509
ETV1 ets variant 1 -0.0266199
SEC31A SEC31 homolog A (S. cerevisiae) -0.0263431
KRT81 keratin 81, type II -0.0260596
RPS13 ribosomal protein S13 -0.0257137
RRBP1 ribosome binding protein 1 -0.0256764
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0256004
CALR calreticulin -0.0255783
GCC2 GRIP and coiled-coil domain containing 2 -0.025522
S100A10 S100 calcium binding protein A10 -0.0252478
RPL11 ribosomal protein L11 -0.025222
H3-3B H3.3 histone B -0.0251447
TMEM263 transmembrane protein 263 -0.0249115
SLC38A2 solute carrier family 38, member 2 -0.0243326
RPL36AL ribosomal protein L36a-like -0.0242188
LRRC23 leucine rich repeat containing 23 -0.0241711
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0240957
ZBTB20 zinc finger and BTB domain containing 20 -0.0239384
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0237524
EIF1 eukaryotic translation initiation factor 1 -0.023672
RPL36 ribosomal protein L36 -0.0234251