Ras protein signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. (Gene Ontology, GO_0007265)
External Link http://amigo.geneontology.org/amigo/term/GO:0007265
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Genes

69 genes participating in the Ras protein signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADRA2A adrenoceptor alpha 2A
ARHGAP9 Rho GTPase activating protein 9
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C6ORF89 chromosome 6 open reading frame 89
CCNA2 cyclin A2
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDPF1 cysteine-rich, DPF motif domain containing 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
ERAS ES cell expressed Ras
FGF13 fibroblast growth factor 13
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MRAS muscle RAS oncogene homolog
NF1 neurofibromin 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTN1 netrin 1
PARK7 parkinson protein 7
PLCE1 phospholipase C, epsilon 1
PLK2 polo-like kinase 2
PRKCSH protein kinase C substrate 80K-H
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RALGDS ral guanine nucleotide dissociation stimulator
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGEF1A RasGEF domain family, member 1A
RASGEF1B RasGEF domain family, member 1B
RASGEF1C RasGEF domain family, member 1C
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RGL4 ral guanine nucleotide dissociation stimulator-like 4
RIT2 Ras-like without CAAX 2
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SHTN1 shootin 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPNS1 spinster homolog 1 (Drosophila)
TP53 tumor protein p53
USP50 ubiquitin specific peptidase 50
USP8 ubiquitin specific peptidase 8